Patents by Inventor David Coughlan

David Coughlan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA AND USE OF SAME
    Publication number: 20170196825
    Abstract: The present disclosure provides orally deliverable pharmaceutical compositions comprising DGLA and methods of using same to treat a variety of conditions and disorders.
    Type: Application
    Filed: January 6, 2017
    Publication date: July 13, 2017
    Inventors: Mehar Manku, John Climax, David Coughlan, James Dunne
  • COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF USING THE SAME
    Publication number: 20170172965
    Abstract: The present invention relates to the compositions comprising 15-HEPE and methods of treatment relating to same.
    Type: Application
    Filed: December 19, 2016
    Publication date: June 22, 2017
    Inventors: David Coughlan, John Climax
  • Pharmaceutical compositions comprising DGLA and use of same
    Patent number: 9682055
    Abstract: The present disclosure provides orally deliverable pharmaceutical compositions comprising DGLA and to methods of using same to treat a variety of conditions and disorders.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: June 20, 2017
    Assignee: DIGNITY SCIENCES LIMTED
    Inventors: Mehar Manku, John Climax, David Coughlan, James Dunne
  • Methods of making 15-hydroxy fatty acid derivatives
    Patent number: 9670126
    Abstract: The present disclosure provides methods of making 15-hydroxy fatty acid derivatives, such as 15-(S)-hydroxyeicosatrienoic acid (HETrE or 15-(S)-HETrE) or 15(S)-hydroxyeicosapentaenoic acid (HEPE or 15(S)-HEPE) from the corresponding fatty acid (e.g., dihomo-?-linolenic acid (DGLA) or eicosapentaenoic acid (EPA), respectively). In some embodiments, the method comprises contacting the fatty acid with an oxidizing agent (e.g., a lipoxygenase and oxygen) in the presence of a reducing agent (e.g., cysteine) to form the 15-hydroxy fatty acid derivatives in a single reaction vessel.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: June 6, 2017
    Assignee: DIGNITY SCIENCES LIMITED
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA AND USE OF SAME
    Publication number: 20170071890
    Abstract: The present disclosure provides orally deliverable pharmaceutical compositions comprising DGLA and to methods of using same to treat a variety of conditions and disorders.
    Type: Application
    Filed: November 4, 2016
    Publication date: March 16, 2017
    Inventors: Mehar Manku, John Climax, David Coughlan, James Dunne
  • Compositions Comprising 15-HEPE and Methods of Treating or Preventing Cancer and Neurologic Disease
    Publication number: 20170020836
    Abstract: The present disclosure provides compositions comprising 15-HEPE and methods of using same for treating and/or preventing cancer and neurological diseases in a subject in need thereof.
    Type: Application
    Filed: July 21, 2016
    Publication date: January 26, 2017
    Inventors: John Climax, Mehar Manku, David Coughlan
  • Compositions Comprising 15-oxo-EPA or 15-oxo-DGLA and Methods of Making and Using Same
    Publication number: 20160362358
    Abstract: The present disclosure provides 15-oxo-EPA and 15-oxo-DGLA, compositions comprising 15-oxo-EPA and/or 15-oxo-DGLA, and methods of treating and/or preventing fibrosis, skin disorders, inflammation, kidney disease or renal dysfunction in a subject in need thereof by administering 15-oxo-EPA and/or 15-oxo-DGLA.
    Type: Application
    Filed: May 12, 2016
    Publication date: December 15, 2016
    Inventors: Mehar Manku, John Climax, David Coughlan
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA AND USE OF SAME
    Publication number: 20150352053
    Abstract: The present disclosure provides orally deliverable pharmaceutical compositions comprising DGLA and to methods of using same to treat a variety of conditions and disorders.
    Type: Application
    Filed: June 4, 2015
    Publication date: December 10, 2015
    Inventors: Mehar Manku, John Climax, David Coughlan, James Dunne
  • Cosmetic compositions comprising EPA and GLA and methods of making and using same
    Patent number: 9192674
    Abstract: The present disclosure is directed generally to cosmetic compositions comprising EPA free acid and GLA free acid. In some embodiments, the cosmetic compositions have a cosmetically acceptable odor.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: November 24, 2015
    Assignee: Dignity Sciences Limited
    Inventors: Mehar Manku, John Climax, David Coughlan
  • COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20150290225
    Abstract: The present disclosure provides compositions and methods for the treatment of disease and/or disorders of this skin.
    Type: Application
    Filed: April 9, 2015
    Publication date: October 15, 2015
    Inventors: John Climax, Mehar Manku, David Coughlan
  • Pharmaceutical compositions comprising DGLA, 15-HEPE, and/or 15-HETrE and methods of use thereof
    Patent number: 9056086
    Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used singly or in combination with anti-bacterial agents for the treatment of disease and/or disorders such as acne or atopic dermatitis.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: June 16, 2015
    Assignee: Dignity Sciences Limited
    Inventors: Mehar Manku, John Climax, David Coughlan
  • Pharmaceutically Acceptable Salts of Fatty Acids
    Publication number: 20150152034
    Abstract: The present disclosure provides pharmaceutically acceptable stable salt forms of 15-lipoxygenase products, such as 15-HETrE lysine salt, compositions comprising same and methods of making and using same.
    Type: Application
    Filed: November 17, 2014
    Publication date: June 4, 2015
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • METHODS OF MAKING 15-HYDROXY FATTY ACID DERIVATIVES
    Publication number: 20150119593
    Abstract: The present disclosure provides methods of making 15-hydroxy fatty acid derivatives, such as 15-(S)-hydroxyeicosatrienoic acid (HETrE or 15-(S)-HETrE) or 15(S)-hydroxyeicosapentaenoic acid (HEPE or 15(S)-HEPE) from the corresponding fatty acid (e.g., dihomo-?-linolenic acid (DGLA) or eicosapentaenoic acid (EPA), respectively). In some embodiments, the method comprises contacting the fatty acid with an oxidizing agent (e.g., a lipoxygenase and oxygen) in the presence of a reducing agent (e.g., cysteine) to form the 15-hydroxy fatty acid derivatives in a single reaction vessel.
    Type: Application
    Filed: October 29, 2014
    Publication date: April 30, 2015
    Inventors: Mehar Manku, David Coughlan, Bill Downes
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA AND/OR 15-HETRE AND METHODS OF USE THEREOF
    Publication number: 20150093344
    Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, and/or 15-HETrE, used singly or in combination for the prevention and/or treatment of effects associated with UV radiation such as erythema.
    Type: Application
    Filed: December 9, 2014
    Publication date: April 2, 2015
    Inventors: Mehar Manku, John Climax, David Coughlan
  • PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA, 15-OHEPA, AND/OR 15-HETRE AND METHODS OF REDUCING SEBUM PRODUCTION USING SAME
    Publication number: 20150094370
    Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used singly or in combination with anti-bacterial agents for the inhibition of sebum production.
    Type: Application
    Filed: December 11, 2014
    Publication date: April 2, 2015
    Inventors: Mehar Manku, David Coughlan, Bill Downes, John Climax
  • Pharmaceutical compositions comprising DGLA and/or 15-HETrE and methods of use thereof
    Patent number: 8936803
    Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, and/or 15-HETrE, used singly or in combination for the prevention and/or treatment of effects associated with UV radiation such as erythema.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: January 20, 2015
    Assignee: Dignity Sciences Limited
    Inventors: Mehar Manku, John Climax, David Coughlan
  • ANTIMICROBIAL COMPOSITIONS COMPRISING DGLA AND NEOMYCIN SULFATE AND METHODS OF USE THEREOF
    Publication number: 20140171358
    Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used alone or in combination with one or more antibiotic agents for the treatment of disease and/or disorders such as a skin infection or wound healing.
    Type: Application
    Filed: February 21, 2014
    Publication date: June 19, 2014
    Applicant: Dignity Sciences Limited
    Inventors: Mehar Manku, John Climax, Jonathan Rowe, David Coughlan
  • Cosmetic compositions comprising EPA and salicylic acid and methods of making and using same
    Patent number: 8673325
    Abstract: The present disclosure is directed generally to cosmetic compositions comprising EPA free acid and salicylic acid. In some embodiments, the cosmetic compositions have a cosmetically acceptable odor.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: March 18, 2014
    Assignee: Dignity Sciences Limited
    Inventors: Mehar Manku, John Climax, David Coughlan
  • COSMETIC COMPOSITIONS COMPRISING EPA AND SALICYLIC ACID AND METHODS OF MAKING AND USING SAME
    Publication number: 20140066507
    Abstract: The present disclosure is directed generally to cosmetic compositions comprising EPA free acid and salicylic acid. In some embodiments, the cosmetic compositions have a cosmetically acceptable odor.
    Type: Application
    Filed: May 31, 2013
    Publication date: March 6, 2014
    Applicant: Dignity Sciences Limited
    Inventors: Mehar Manku, John Climax, David Coughlan
  • COSMETIC COMPOSITIONS COMPRISING EPA AND GLA AND METHODS OF MAKING AND USING SAME
    Publication number: 20140066509
    Abstract: The present disclosure is directed generally to cosmetic compositions comprising EPA free acid and GLA free acid. In some embodiments, the cosmetic compositions have a cosmetically acceptable odor.
    Type: Application
    Filed: September 6, 2013
    Publication date: March 6, 2014
    Applicant: DIGNITY SCIENCES LIMITED
    Inventors: Mehar Manku, John Climax, David Coughlan