Abstract: A trip-planning operation includes identifying a primary work location associated with each user account of a dependency graph defined by the three or more users performing a set of interaction events on a software platform. A first set of advanced programming interface (API) calls is generated to a third party service to obtain one or more query results based on the primary work location, which are then analyzed to determine a ranked list of candidate trip locations based on a ranking criterion. At least a portion of the ranked list is displayed on the client device and, in response to an input from the client device and upon a determination that a consensus regarding the candidate trip location exists among the three or more user accounts, a second API call is generated to the third party service to book a trip to the candidate trip location for each user account.

Abstract: A mascot retraction mechanism has a support (6) movably mounted to a track (5) for movement between a mascot deployed position and a mascot stowed position. A drive mechanism (7, 34, 35) may be arranged to drive the support along the track via a releasable latch (30). The releasable latch may be released by tilting of a mascot able to enable the support to move along the track free of the drive mechanism.

Abstract: The present invention discloses an atomizer. The atomizer includes a concentrate reservoir volume that is in fluid communication with a concentrate vaporization assembly. The concentrate vaporization assembly includes a frit adapted to absorb concentrate from the concentrate reservoir volume. The concentrate vaporization assembly further includes a heating element adapted to heat the frit and absorbed concentrate. The atomizer further includes a vapor collection and discharge assembly including a vapor accumulation chamber in fluid communication with the frit and a vapor evacuation channel in fluid communication with the vapor accumulation chamber and in fluid communication with an egress port. The heating element is activated by a user control of a switch on a battery, which causes the concentrate contained within the frit filter to vaporize, and the user inhales resulting vapor by inhaling at the egress port of the vapor evacuation channel.

Abstract: The present invention is directed towards a vaporization device that uses a vaporization media, The vaporization media used is an inherently non-porous solid having frustal voids that are specially formed to provide improved capillary action, and vaporization properties of high vaporization rate, tolerance to wide gamut of Extract types and viscosities, dramatic reduction in non-Extract media-emitted inhalable particulate or vapor, as well as collateral benefits such as fluid containment sealing, and manufacturability that are presently impossible with traditional vaporization media.

Abstract: The present invention discloses an atomizer. The atomizer includes a concentrate reservoir volume that is in fluid communication with a concentrate vaporization assembly. The concentrate vaporization assembly includes a frit adapted to absorb concentrate from the concentrate reservoir volume. The concentrate vaporization assembly further includes a heating element adapted to heat the frit and absorbed concentrate. The atomizer further includes a vapor collection and discharge assembly including a vapor accumulation chamber in fluid communication with the frit and a vapor evacuation channel in fluid communication with the vapor accumulation chamber and in fluid communication with an egress port. The heating element is activated by a user control of a switch on a battery, which causes the concentrate contained within the frit filter to vaporize, and the user inhales resulting vapor by inhaling at the egress port of the vapor evacuation channel.

Abstract: The invention provides the compound 5-chloro-4-hydroxy-1-methyl-2-oxo-N-phenyl-quinoline-3-carboxamide potassium salt. It is considered to have the structure of formula (I): The compound is provided in solid (eg crystalline or amorphous) or aqueous solution form. Pharmaceutical compositions comprising the compound are also provided. The compound finds use as a medicament, in particular for the treatment or prophylaxis of an inflammatory bowel disease.

Abstract: Provided herein are certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to treat certain diseases, such as liver fibrosis, e.g., in the setting of NASH or ASH.

Abstract: A pumping system includes a pump array of multiple pump-engine assemblies. Each pump-engine assembly comprises a pump and a gas turbine engine driving the pump. A manifold is coupled to the pumps. A master controller is coupled to each of the pump-engine assemblies either directly or via one or more intermediate controllers. The master controller and any intermediate controllers are collectively programmed to respond to user input including a desired hydraulic output at the manifold by automatically calculating and applying inputs to the individual pump-engine assemblies to provide the desired hydraulic output.

Abstract: Presented is a smoking product making system as well as methods for producing a plurality of smoking products. The smoking product making system comprises a receptacle configured to releasably hold pre rolled cones, a closure device configured for closing the top end of the pre rolled cones filled with smoking material, and an ejector device configured to push the bottom end of each pre rolled cone. The smoking product making system as well as method is capable of simultaneously producing a plurality of finished smoking products (such as cigarettes) with equal precision by enabling application of equal force for closing the top ends of the pre rolled cones.

Abstract: Provided herein are certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. He conjugates are useful to treat certain diseases, such as acromegaly.

Abstract: The present invention is directed towards a vaporization device that uses a vaporization media, The vaporization media used is an inherently non-porous solid having a plurality of frustal voids that are specially formed to provide improved capillary action and vaporization properties of high vaporization rate, tolerance to wide gamut of Extract types and viscosities, dramatic reduction in non-Extract media-emitted inhalable particulate or vapor, as well as collateral benefits such as fluid containment sealing, and manufacturability that are presently impossible with traditional vaporization media.

Abstract: It is the object of the present invention to eliminate the disadvantages of the traditional dabbing method by providing a device and associated method that will reliably allow users to divide and collect a desired small quantity of Extract from a larger or bulk quantity of Extract and to conduct the small quantity of extract toward a Vaporizer heating element with minimal loss or wastage of Extract during the process, while significantly reducing required precision and effort associated Extract handling. The present invention of device and associated method result in a simpler, cleaner, and more efficient dabbing process.

Abstract: It is an objective of the present invention to reduce the disadvantages in currently available Vaporizers by providing a method and system of controlling the output voltage of the Battery such that the electrical current within and the temperature of the heating element and Extract are controllable. The present invention discloses the Battery that operates by supplying voltage that varies with time and provides various automatically or manually selectable voltage-time profiles. The voltage is controlled by an integrated controller that is able to vary the battery output voltage via voltage modulation and is able to continuously vary the output voltage. The voltage is modulated using pulse width modulation. The integrated controller is capable of storing and executing an embedded program for voltage modulation.

Abstract: It is the object of the present invention to eliminate the disadvantages in currently available Vaporizers. The present invention is adapted for use with semi-solid Extracts, which are immune to leakage and do not contain solvents. Furthermore, the present invention is easily operated by users and does not require Dabbing.

Abstract: It is the object of the present invention to reduce the amount of labor that is required for distal closure of a cigarette or joint by providing a device and related method for folding and dimpling the distal tip of a joint through single actuation.

Abstract: The present invention is a method for vaporizing concentrate that will substantially eliminate general or localized burning of concentrate during the vaporization process and a vaporizer device adapted for carrying out the vaporization method. The vaporization method is based on heating concentrate that has been absorbed into a frit, preferably fritted glass. Fritted glass is characterized by open-pore interstices that allow free passage of fluid through the frit. It is commonly used as a filtering element, particularly in high-temperature applications. It is discovered that concentrate placed in contact with fritted glass is absorbed through capillary action. The concentrate at room temperature may not readily seep fully into fritted glass, as concentrate is heated its viscosity is reduced such that it is readily absorbed by the fritted glass and upon further heating the fritted glass and absorbed concentrate, the vapor of the concentrate is generated for inhalation.

Abstract: A system controller manages a gas turbine engine driving a pump directly or indirectly coupled to the engine. The controller is programmed to automatically determine and adjust inputs to the gas turbine engine in order to cause the pump to produce a user-specified hydraulic output.

Abstract: The present invention is a method for vaporizing concentrate that will substantially eliminate general or localized burning of concentrate during the vaporization process and a device adapted for carrying out said method. The vaporization method is based on heating concentrate that has been absorbed into a frit, preferably fitted glass. Fritted glass is characterized by open-pore interstices that allow free passage of fluid through the frit. It is commonly used as a filtering element, particularly in high-temperature applications. It was discovered that concentrate placed in contact with fitted glass is absorbed through capillary action. Although room temperature concentrate may not readily seep fully into fritted glass, as concentrate is heated its viscosity is reduced such that it is readily absorbed by the fitted glass.