Abstract: The present invention is concerned with an electric utility brush having a flexible drive shaft, and in particular an electric toothbrush having a substantially spherical head mounted on the flexible drive shaft and which can be driven rotationally in at least two different orientations in order to provide comprehensive brushing capabilities.

Abstract: The present invention provides a template for a tufted curved surface such as a hemispherical brush head for an electric toothbrush or the like, the template comprising a substrate having an upper surface adapted to carry one or more tufts of bristles such as to project outwardly from the upper surface, the substrate being shaped to be deformable between an expanded state in which the upper surface is substantially flat, and a collapsed state in which the upper surface is curved.

Abstract: A mould system for producing a tufted body having a curved outer surface, for example one hemispherical half of a spherical toothbrush head, the mould system comprising a mould form having a receptacle and an annular flange circumscribing an open end of the receptacle and at least one slot formed substantially radially in the flange and extending into a sidewall of the receptacle.

Abstract: The present invention is concerned with a toothbrush, in particular an electric or otherwise driven toothbrush having a rotatable head, wherein the head incorporates arrays of bristle tufts, at least some of which extend substantially radially of the axis of rotation.

Abstract: Systems and methods for serving dynamic content (such as advertisements) in response to dynamic content requests are presented. More particularly, systems and methods for serving dynamic content from dynamic content portfolios directed to trending events and/or topics are presented. Upon receiving a dynamic content request, content classifications corresponding to the requested, published content (i.e., the requested content) that included reserved dynamic content space which initiated the dynamic content request are determined. A current trend is identified in a content classification when the dynamic content request volume for the current trend period exceeds the standard/expected dynamic content request volume for the current trend period by at least a threshold amount. When a trend is detected, candidate content portfolios directed to the trending content classification are selected from a set trending content portfolios.

Abstract: The present invention provides a drive system having particular utility in an electric toothbrush, the drive system comprising a coupling (14) which is connectable between a drive source (12) and a brush head (16), the coupling being adapted to impart first and second independent brushing motions to the head.

Abstract: Systems and methods for serving dynamic content (such as advertisements) in response to dynamic content requests are presented. More particularly, systems and methods for serving dynamic content from dynamic content portfolios directed to trending events and/or topics are presented. Upon receiving a dynamic content request, content classifications corresponding to the requested, published content (i.e., the requested content) that included reserved dynamic content space which initiated the dynamic content request are determined. A current trend is identified in a content classification when the dynamic content request volume for the current trend period exceeds the standard/expected dynamic content request volume for the current trend period by at least a threshold amount. When a trend is detected, candidate content portfolios directed to the trending content classification are selected from a set trending content portfolios.

Abstract: A method. The method includes receiving, at a computing device, data associated with a first plurality of consumers. The data comprises a combination of behavioral data and attitudinal data. The method also includes assigning a consumer of the first plurality of consumers to a first respective segments based on the received data, wherein the assigning is performed by the computing device. The method further includes calculating a goodness-of-fit score for the consumer of the first plurality of consumers for the first segment, wherein the calculating is performed by the computing device. Additionally, the method includes calculating a predicted goodness-of-fit score for a consumer of a second plurality of consumers for the first segment, the second plurality of consumers including at least the first plurality of consumers, wherein the calculating is performed by the computing device.

Abstract: A system. The system includes a computing device, an authentication module, an instruction module and a tracking module. The computing device includes a processor. The authentication module is communicably connected to the processor and is configured to authenticate that a person is associated with a third-party associated with a store. The instruction module is communicably connected to the processor and is configured to coordinate work instructions to be completed at the store. The tracking module is communicably connected to the processor and is configured to track information associated with the person.

Abstract: The present invention provides a toothbrush (710), in particular a mechanical toothbrush (710) more commonly known as an electric toothbrush (710), which includes a spherical brush head (712) which is capable of undergoing at least first (720) and second (722) independent brushing motions in order to improve the overall brushing effectiveness.

Abstract: A system. The system includes a computing device and a combiner module. The computing device includes a processor. The combiner module is communicably connected to the processor, and is configured to combine a score generated by a behavioral targeting model with a score generated by an attitudinal targeting model.

Abstract: The present invention provides a drive system having particular utility in an electric toothbrush, the drive system comprising a coupling (14) which is connectable between a drive source (12) and a brush head (16), the coupling being adapted to impart first and second independent brushing motions to the head.

Abstract: A method. The method is implemented at least in part by a computing device. The method includes matching information in a first database with corresponding entries in a second database, utilizing a targeting engine to calculate a score for at least a portion of the consumers in the first database, and ranking at least a portion of the consumers in the first database based on the calculated scores. The second database is larger than the first database. The method also includes comparing media behavior of a first group of ranked consumers in the first database with media behavior of a second group of consumers in the first database. The matching, calculating, ranking and comparing are performed by the computing device.

Abstract: A method. The method includes receiving, at a computing device, data associated with a first plurality of consumers. The data comprises a combination of behavioral data and attitudinal data. The method also includes assigning a consumer of the first plurality of consumers to a first respective segments based on the received data, wherein the assigning is performed by the computing device. The method further includes calculating a goodness-of-fit score for the consumer of the first plurality of consumers for the first segment, wherein the calculating is performed by the computing device. Additionally, the method includes calculating a predicted goodness-of-fit score for a consumer of a second plurality of consumers for the first segment, the second plurality of consumers including at least the first plurality of consumers, wherein the calculating is performed by the computing device.

Abstract: A method. The method includes receiving, at a computing device, data associated with a first plurality of consumers. The method also includes assigning a consumer of the first plurality of consumers to a first respective segments based on the received data, wherein the assigning is performed by the computing device. The method further includes calculating a goodness-of-fit score for the consumer of the first plurality of consumers for the first segment, wherein the calculating is performed by the computing device. Additionally, the method includes calculating a predicted goodness-of-fit score for a consumer of a second plurality of consumers for the first segment, the second plurality of consumers including at least the first plurality of consumers, wherein the calculating is performed by the computing device. The method further includes screening at least some of the second plurality of consumers, wherein the screening is performed by the computing device.

Abstract: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally, classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

Abstract: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally, classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

Abstract: Disclosed herein are vaccines and methods for inducing an immune response against cancer cells and cells infected with intracellular parasites. Vaccines having housekeeping epitopes are disclosed. The housekeeping epitope is formed by housekeeping proteasomes in peripheral cells, but not by professional antigen presenting cells. A vaccine containing a housekeeping epitope that is derived from an antigen associated with a peripheral target cell can thus direct an immune response against the target cell. Methods of treatment are also disclosed, which involve administering a vaccine having a housekeeping epitope.

Abstract: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally, classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

Abstract: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally, classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.