Abstract: Disclosed herein are vaccines and methods for inducing an immune response against cancer cells and cells infected with intracellular parasites. Vaccines having housekeeping epitopes are disclosed. The housekeeping epitope is formed by housekeeping proteasomes in peripheral cells, but not by professional antigen presenting cells. A vaccine containing a housekeeping epitope that is derived from an antigen associated with a peripheral target cell can thus direct an immune response against the target cell. Methods of treatment are also disclosed, which involve administering a vaccine having a housekeeping epitope.

Abstract: Disclosed herein are methods and compositions for inducing an immune response against various combinations of tumor-associated antigens, which can promote effective immunologic intervention in pathogenic processes. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs for the immunotherapy of patients with various types of cancer. Both immunogenic compositions for inducing an immune response to these combinations of antigens and methods for their use are disclosed.

Abstract: A system and method for delivering purchasing incentives and a variety of other retail shopping aids through a computer network, such as by E-mail over the Internet or the World Wide Web. Customers (10) of retail stores can establish a bi-directional communication link with the system, log in (16) to the system, and then elect to browse among available purchasing incentive offers (18, 22), or elect to explore other shopping aids, such as a shopping list generator (26), a recipe center (30), or simply elect to claim a product rebate or to receive product information. If the customer elects to have product information or rebate information delivered, only minimal customer identification is required. For purchase incentives redeemable at retail stores, the customer must provide identification information and must also designate a retailer (12) at which the purchasing incentive can be exercised.

Abstract: A method of epitope discovery comprising the step of selecting an epitope from a population of peptide fragments of an antigen associated with a target cell, wherein the fragments have a known or predicted affinity for a major histocompatibility complex class I receptor peptide binding cleft, wherein the epitope selected corresponds to a proteasome cleavage product of the target cell.

Abstract: A system and method for playing back data segments stored in one or more locations and managed by one or more playback servers. In a preferred embodiment the system and method receive data describing data segments to be played back; transmit notifications to the playback servers to prepare for playback; and transmit playback requests to the playback servers. The system and method are also capable of playing back the segments in a specified order and such that gaps between the segments are minimized. Additionally, a graphical display can be provided to display the status of the segments being played back.

Abstract: A system and method for playing back data segments stored in one or more locations and managed by one or more playback servers. In a preferred embodiment the system and method receive data describing data segments to be played back; transmit notifications to the playback servers to prepare for playback; and transmit playback requests to the playback servers. The system and method are also capable of playing back the segments in a specified order and such that gaps between the segments are minimized. Additionally, a graphical display can be provided to display the status of the segments being played back.

Abstract: A mounting device includes a first component and a second component. The first component has a forwardly disposed nose, a rearwardly disposed and outwardly flared cutting member, and a bore extending through the nose and cutting member and which is threaded at least along part of its length. The second component comprises a tube for fitting over the nose of the first component. In use, when the tube is fitted over the nose 15 and forced in an axial direction against the cutting member the latter progressively splits the tube substantially parallel to its axis into a plurality of “petals” which become mutually splayed out radially with respect to the axis of the bore.

Abstract: This invention relates to histo-blood group O alleles of baboon. The major O allele retains identifying sequence characteristics of the baboon A allele. Other alleles, including a B-like allele, are also disclosed herein. The O alleles of baboon are closer in sequence similarity to the baboon A and B alleles than are any of the baboon ABO alleles to the human alleles of the ABO locus. This invention also provides materials and methods for identifying O alleles, and carriers of O alleles, as well as methods for producing baboons and baboon cells, tissues, and organs having a group O phenotype. Group O baboons, cells, tissues, and organs of the invention are useful for xenotransplantation.

Abstract: A system and method for playing back data segments stored in one or more locations and managed by one or more playback servers. In a preferred embodiment the system and method receive data describing data segments to be played back; transmit notifications to the playback servers to prepare for playback; and transmit playback requests to the playback servers. The system and method are also capable of playing back the segments in a specified order and such that gaps between the segments are minimized. Additionally, a graphical display can be provided to display the status of the segments being played back.

Abstract: A plurality of piston-sealed cylinders are secured in oppositely disposed units in spaced relationship to each other about the circumference of a rotational member having substantially horizontal axes of rotation. The rotational member and all cylinders are submerged within a fluid medium. Cylinders on the vertically upwardly moving side of the rotational member have their pistons withdrawn from sealed ends of the cylinders to create a large air space, reducing the weight of each such cylinder to less than the weight of the quantity of the fluid medium which each such cylinder displaces thereby giving each such cylinder buoyancy in the fluid medium and the tendency to rise therein.