Patents by Inventor David Dodd

David Dodd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES
    Publication number: 20260147001
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Application
    Filed: July 24, 2025
    Publication date: May 28, 2026
    Inventors: Asmamaw WASSIE, Daniel Masao ESTANDIAN, Andrew John PRICE, Boyang HUA, Joshua Young Cynming YANG, David DODD, Gerardo Fabian DELGADO, Elaine Jean SU
  • HIGH INTENSITY LABELED REACTANT COMPOSITIONS AND METHODS FOR SEQUENCING
    Publication number: 20260125754
    Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
    Type: Application
    Filed: March 22, 2023
    Publication date: May 7, 2026
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
  • PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES
    Publication number: 20260118364
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Application
    Filed: July 24, 2025
    Publication date: April 30, 2026
    Inventors: Asmamaw WASSIE, Daniel Masao ESTANDIAN, Andrew John PRICE, Boyang HUA, Joshua Young Cynming YANG, David DODD, Gerardo Fabian DELGADO, Elaine Jean SU
  • High intensity labeled reactant compositions and methods for sequencing
    Patent number: 12577607
    Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
    Type: Grant
    Filed: March 27, 2023
    Date of Patent: March 17, 2026
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
  • SUBSTRATE CLEAVAGE FOR NUCLEIC ACID SYNTHESIS
    Publication number: 20250369027
    Abstract: Disclosed herein are methods and compositions for cleavage of nucleic acids from a surface of a solid support. Further described herein are cleavage methods compatible with enzymatic and chemical nucleic acid synthesis methods.
    Type: Application
    Filed: April 6, 2023
    Publication date: December 4, 2025
    Inventors: Jeremy LACKEY, David DODD, Heera LANGNER
  • Protein sequencing via coupling of polymerizable molecules
    Patent number: 12399180
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers having an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Grant
    Filed: February 19, 2025
    Date of Patent: August 26, 2025
    Assignee: Glyphic Biotechnologies, Inc.
    Inventors: Asmamaw Wassie, Daniel Masao Estandian, Andrew John Price, Boyang Hua, Joshua Young Cynming Yang, David Dodd, Gerardo Fabian Delgado, Elaine Jean Su
  • Protein sequencing via coupling of polymerizable molecules
    Patent number: 12399181
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers having an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Grant
    Filed: February 19, 2025
    Date of Patent: August 26, 2025
    Inventors: Asmamaw Wassie, Daniel Masao Estandian, Andrew John Price, Boyang Hua, Joshua Young Cynming Yang, David Dodd, Gerardo Fabian Delgado, Elaine Jean Su
  • SINGLE-MOLECULE PEPTIDE SEQUENCING USING XANTHATE AMINO ACID REACTIVE GROUPS
    Publication number: 20250188538
    Abstract: The present disclosure provides reagents and methods useful for single-molecule sequencing of proteins through use of a unique sequencing reagent comprising a xanthate group. The reagents and methods described herein provide for high-throughput single-molecule peptide and protein sequencing in mild conditions allowing for high resolution investigation of the complex biological systems.
    Type: Application
    Filed: November 20, 2024
    Publication date: June 12, 2025
    Inventors: Joshua Young Cynming YANG, Jai PRAKASH, Asmamaw WASSIE, Daniel Masao ESTANDIAN, David DODD, Ronald Joseph GRAHAM
  • PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES
    Publication number: 20250180576
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Application
    Filed: February 19, 2025
    Publication date: June 5, 2025
    Inventors: Asmamaw WASSIE, Daniel Masao ESTANDIAN, Andrew John PRICE, Boyang HUA, Joshua Young Cynming YANG, David DODD, Gerardo Fabian DELGADO, Elaine Jean SU
  • PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES
    Publication number: 20250180577
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Application
    Filed: February 19, 2025
    Publication date: June 5, 2025
    Inventors: Asmamaw WASSIE, Daniel Masao ESTANDIAN, Andrew John PRICE, Boyang HUA, Joshua Young Cynming YANG, David DODD, Gerardo Fabian DELGADO, Elaine Jean SU
  • Biconjugatable labels and methods of use
    Patent number: 12312377
    Abstract: Aspects of the disclosure provide biconjugatable labels, labeled biomolecules, and methods of using and making the same.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: May 27, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Roger Nani, David Dodd
  • METHODS AND SYSTEMS FOR PROCESSING POLYMERIC ANALYTES
    Publication number: 20250155447
    Abstract: Novel approaches for processing polymeric analytes, such as biopolymers, are provided herein. A method for processing a polymeric analyte may comprise coupling a monomer of the polymeric analyte to a capture moiety, cleaving the monomer from the polymeric analyte, and analyzing the cleaved monomer, e.g., using a binding agent. The methods described herein may employ the use of activating agents.
    Type: Application
    Filed: October 7, 2024
    Publication date: May 15, 2025
    Inventors: David DODD, YashoNandini SINGH, Daniel Masao Estandian, Andrew John PRICE, Asmamaw WASSIE, Boyang HUA, Jai PRAKASH, Joshua Young Cynming YANG
  • Protein sequencing via coupling of polymerizable molecules
    Patent number: 12259393
    Abstract: “The present disclosure provides methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers having an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Grant
    Filed: April 4, 2024
    Date of Patent: March 25, 2025
    Assignee: Glyphic Biotechnologies, Inc.
    Inventors: Asmamaw Wassie, Daniel Masao Estandian, Andrew John Price, Boyang Hua, Joshua Young Cynming Yang, David Dodd, Gerardo Fabian Delgado, Elaine Jean Su
  • Protein sequencing via coupling of polymerizable molecules
    Patent number: 12259394
    Abstract: The present disclosure provides methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers having an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Grant
    Filed: April 4, 2024
    Date of Patent: March 25, 2025
    Assignee: Glyphic Biotechnologies, Inc.
    Inventors: Asmamaw Wassie, Daniel Masao Estandian, Andrew John Price, Boyang Hua, Joshua Young Cynming Yang, David Dodd, Gerardo Fabian Delgado, Elaine Jean Su
  • METHODS OF SYNTHESIZING OLIGONUCLEOTIDES USING TETHERED NUCLEOTIDES
    Publication number: 20240344057
    Abstract: Disclosed herein are methods and compositions comprising a polymerase and a phosphorylated nucleoside, wherein the polymerase and the nucleoside are covalently linked by a cleavable linker at the terminal phosphate group. Further disclosed herein are enzymatic polynucleotide synthesis using polymerase and nucleotide conjugation strategies.
    Type: Application
    Filed: April 26, 2024
    Publication date: October 17, 2024
    Inventors: Jeremy LACKEY, David DODD
  • PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES
    Publication number: 20240337661
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Application
    Filed: April 4, 2024
    Publication date: October 10, 2024
    Inventors: Daniel Masao ESTANDIAN, Asmamaw WASSIE, Andrew John PRICE, Boyang HUA, Joshua Young Cynming YANG, David DODD, Gerardo Fabian DELGADO, Elaine Jean SU
  • PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES
    Publication number: 20240337660
    Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.
    Type: Application
    Filed: April 4, 2024
    Publication date: October 10, 2024
    Inventors: Daniel Masao ESTANDIAN, Asmamaw WASSIE, Andrew John PRICE, Boyang HUA, Joshua Young Cynming YANG, David DODD, Gerardo Fabian DELGADO, Elaine Jean SU
  • Methods of synthesizing oligonucleotides using tethered nucleotides
    Patent number: 11970697
    Abstract: Disclosed herein are methods and compositions comprising a polymerase and a phosphorylated nucleoside, wherein the polymerase and the nucleoside are covalently linked by a cleavable linker at the terminal phosphate group. Further disclosed herein are enzymatic polynucleotide synthesis using polymerase and nucleotide conjugation strategies.
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: April 30, 2024
    Assignee: Twist Bioscience Corporation
    Inventors: Jeremy Lackey, David Dodd
  • HIGH INTENSITY LABELED REACTANT COMPOSITIONS AND METHODS FOR SEQUENCING
    Publication number: 20240124918
    Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
    Type: Application
    Filed: March 27, 2023
    Publication date: April 18, 2024
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
  • HIGH INTENSITY LABELED REACTANT COMPOSITIONS AND METHODS FOR SEQUENCING
    Publication number: 20240068027
    Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
    Type: Application
    Filed: March 22, 2023
    Publication date: February 29, 2024
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd