Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The generation of a web site preview based on client presentation state of the client that will render the web site preview. Upon a service receiving a request to provide preview data for a web site preview corresponding to a web site identifier, the service determines client presentation state of the client(s) that is or are to render a web site preview using preview data that is to be provided in response to the request. The service selects a preview template at least in part based on the determined client presentation state. The service also populates the selected preview template with content from the web site to thereby generate preview data representing a preview of the web site identified by the web site identifier. The preview data is thus tailored to the presentation state of the client.

Abstract: A system for determining intestinal potential difference. The system includes a measurement probe including a measurement tube having a measurement lumen which houses a measurement electrode therein, a measurement fluid delivery system in fluid communication with the measurement lumen, the measurement fluid delivery system being configured to deliver an electrically-conductive fluid into the measurement lumen such that the electrically-conductive fluid is electrically coupled to the measurement electrode, and the measurement lumen including an outlet at a distal end thereof through which the electrically-conductive fluid exits the measurement lumen and contacts an intestinal tissue of a subject to provide electrical coupling between the measurement electrode and the intestinal tissue; a controller coupled to the measurement electrode configured to measure a potential difference between tire measurement electrode and a reference electrode electrically coupled to the subject.

Abstract: This disclosure relates to a method for managing installation of applications, where the method includes receiving, from a first computing device associated with an administrator of an organization, a pin request to attach an application, provided by an application store platform, with a version of the application, initiating, in response to the pin request, transfer of a copy of the version of the application from the application store platform to a data storage device, generating an application identifier that identifies a location of the version of the application stored in the data storage device, and transmitting installation data to a second computing device that is managed by the organization. The installation data includes the application identifier, which is used by the second computing device to install the version of the application from the data storage device.

Abstract: Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.

Abstract: Provided here are antibodies that bind Protein S, and methods of making and using such antibodies. In some embodiments, the Protein S antibodies provided herein are useful for treating a bleeding disorder or platelet disorder, or a condition characterized by reduced or impaired blood coagulation and/or clotting.

Abstract: The present disclosure provides an aerogel composition which is intrinsically hydrophobic without surface modification by a hydrophobizing agent, is durable and easy to handle, which has favorable performance in aqueous environments, and which also has favorable combustion and self-heating properties. Also provided is a method of preparing an aerogel composition which is intrinsically hydrophobic without surface modification by a hydrophobizing agent, is durable and easy to handle, which has favorable performance in aqueous environments, and which has favorable combustion and self-heating properties.

Abstract: A backlight includes a substrate, a plurality of light sources proximate the substrate, a first reflective layer on the substrate, and a plurality of patterned reflectors over the plurality of light sources. Each light source includes a size measured in a plane parallel to the substrate. Each patterned reflector is aligned with a corresponding light source and includes a thickness profile. The thickness profile includes a substantially flat section and a curved section extending from and surrounding the substantially flat section. The substantially flat section varies in thickness by no more than plus or minus 20 percent of an average thickness of the substantially flat section. The substantially flat section includes a size in a plane parallel to the substrate equal to or greater than the size of each light source.

Abstract: The present disclosure provides an aerogel composition which is intrinsically hydrophobic without surface modification by a hydrophobizing agent, is durable and easy to handle, which has favorable performance in aqueous environments, and which also has favorable combustion and self-heating properties. Also provided is a method of preparing an aerogel composition which is intrinsically hydrophobic without surface modification by a hydrophobizing agent, is durable and easy to handle, which has favorable performance in aqueous environments, and which has favorable combustion and self-heating properties.

Abstract: A safety walker having a frame with a set of spherical caster wheels connected to the lower portion of the frame to provide omnidirectional movement with reduced force. A braking system is provided, where when a weight exceeding a threshold weight is applied to the frame, the brake is engaged to inhibit movement of the walker on the ground. The brake may use a mechanism in which each spherical caster wheel is retractably mounted within a lower end of a corresponding leg of the frame. Each spherical wheel is spring-loaded to urge the spherical wheel downward from the lower end of the corresponding leg. As weight is applied to the frame, the spherical caster wheel is pushed into the lower end of the leg, allowing the lower end of the leg to contact the ground surface and maintain stationary contact between the leg and the ground surface.

Abstract: An adaptor for incorporating a function of an Open Compute Project (OCP) mezzanine card into a storage device includes a framework, a baseboard mounted to the framework and arranged to have the Open Compute Project (OCP) mezzanine card mounted thereon, an adapting part on the baseboard, the adapting part including an insertion slot for receiving a first interface of the OCP mezzanine card, and a connector on the baseboard, the connector configured to connect with the storage device, the baseboard including interconnections between the connector and the adapting part to provide for data exchange between the OCP mezzanine card and the storage device.

Abstract: Embodiments of the present disclosure relate to a fixing device for a double-sided heat sink and an associated heat dissipating system. There is exemplarily provided a fixing device for mounting the double-sided heat sink on a carrier.

Abstract: Various embodiments of the present disclosure disclose a storage system. The storage system comprises: at least one storage device array enclosure, each of the storage device array enclosure accommodating storage devices, which are arranged in columns and have gaps existing between adjacent storage devices; each storage device array enclosure includes a cap for covering accommodated storage devices; the cap includes vents and windshield bars, such that when the cap is in a closed state, the vents abut against an upper surface of the corresponding storage devices and the windshield bars cover the gaps between adjacent storage devices.

Abstract: In the embodiments of the present disclosure, a device having time division multiplexing capability of heat dissipation is provided, including: a first component and a second component arranged in different orientations; and a heat sink arranged to guide an air flow flowing through the heat sink to the first component and the second component respectively during different time periods. Therefore, the device having time division multiplexing capability of heat dissipation of the present disclosure may reduce the number of heat sinks in the device and thus, reduce the overall size of the device.

Abstract: Embodiments of the present disclosure relate to a stabilizing apparatus for a plug-in card, a chassis including the stabilizing apparatus and associated manufacturing method. The stabilizing apparatus comprises a fixed part adapted for attaching the stabilizing apparatus to a chassis for supporting the plug-in card and a contact part electrically coupled to a ground terminal of the chassis and movable towards the plug-in card supported on the chassis along a first positive direction perpendicular to an extended plane of the plug-in card, so as to contact the plug-in card.

Abstract: Embodiments of the present disclosure provide a system and method for heat dissipation of a storage device. The system comprises a guiding rail mounted in an enclosure of the storage device; a set of fans arranged on the guiding rail and being movable on the guiding rail, the set of fans being configured to dissipate heat of a disk assembly of the storage device; and a controller configured to: obtain a temperature of the disk assembly at a first time point; and in response to the temperature of at least one disk in the disk assembly exceeding a threshold temperature, perform at least one of the following: adjusting a position of at least one of the set of fans; and increasing a rotational speed of at least one of the set of fans.

Abstract: Various embodiments of the present disclosure provide a heat sink for a plug-in storage card and a plug-in storage card including the heat sink. The heat sink comprises a first part secured to a surface of the plug-in storage card and a second part coupled to the first part and being movable relative to the first part in a first direction, wherein the first direction is perpendicular to the surface of the plug-in storage card. In this way, when the second part and the first part have a larger overlap in the first direction, the heat sink has a smaller first height and when the second part and the first part have a smaller overlap in the first direction, the heat sink has a greater second height.

Abstract: Embodiments of the present disclosure relate to an enclosure for a disk array. The enclosure comprises a chassis for receiving the disk array. Each disk in the disk array is enclosed by a frame. The enclosure also comprises a heat sink including a plurality of metal bars arranged on a bottom face of the chassis. Each of the plurality of metal bars is adapted to contact a respective disk through a notch in the frame of the respective disk, to position the respective disk and to transfer heat generated by the respective disk to the chassis. In the embodiments of the present disclosure, the metal bars may be used not only for reliable positioning of the disks, but also for improving thermal dissipation performance.

Abstract: Embodiments of the present disclosure relate to a screw, a manufacturing method thereof and an associated storage device. The screw includes a screw stem at least partly provided with threads; and a head comprising a rolling element, the rolling element protruding out of a surface of the head and adapted to form rolling contact with an object abutting against the head. By the screw according to embodiments of the present disclosure, an effective support can be provided to the storage device, without interfering with the plug operation of the storage device.

Abstract: The present disclosure relates to a storage device and a method of controlling a rotation speed of a fan of the storage device. The storage device comprises: a housing comprising an opening; a fan arranged at an end of the housing opposed to the opening; a tray comprising a plurality of partitions arranged in rows and being operable to be drawn out of or inserted into the housing via the opening in a longitudinal direction of the housing; a plurality of tray position detectors respectively arranged on the plurality of partitions and configured to detect a relative position of the tray with respect to the housing; and a controller adapted to adjust a rotation speed of the fan according to the relative position detected by the tray position detector.