Patents by Inventor David E. Nichols

David E. Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREPARATION OF PSILOCYBIN, DIFFERENT POLYMORPHIC FORMS, INTERMEDIATES, FORMULATIONS AND THEIR USE
    Publication number: 20250122232
    Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
    Type: Application
    Filed: December 20, 2024
    Publication date: April 17, 2025
    Applicant: Compass Pathfinder Limited
    Inventors: Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS
  • SHP2 INHIBITOR COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20250090532
    Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.
    Type: Application
    Filed: May 6, 2024
    Publication date: March 20, 2025
    Inventors: Robert J. Nichols, Mark A. Goldsmith, Christopher Schulze, Jacqueline Smith, David E. Wildes, Stephen Kelsey, Mallika Singh
  • PSILOCIN BENZOATE FORMULATION FOR INTRAVENOUS INFUSION
    Publication number: 20250073207
    Abstract: The invention features psilocin formulations for intravenous infusions including psilocin benzoate salt in combination with an antioxidant.
    Type: Application
    Filed: January 12, 2023
    Publication date: March 6, 2025
    Inventors: Alexander SCHWARZ, David E. NICHOLS, Claire WOMBWELL, David Anthony FLEET
  • PREPARATION OF PSILOCYBIN, DIFFERENT POLYMORPHIC FORMS, INTERMEDIATES, FORMULATIONS AND THEIR USE
    Publication number: 20240360162
    Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
    Type: Application
    Filed: July 9, 2024
    Publication date: October 31, 2024
    Applicant: Compass Pathfinder Limited
    Inventors: Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS
  • METHOD FOR TREATING ANXIETY DISORDERS, HEADACHE DISORDERS, AND EATING DISORDERS WITH PSILOCYBIN
    Publication number: 20240252521
    Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
    Type: Application
    Filed: November 29, 2023
    Publication date: August 1, 2024
    Applicant: Compass Pathfinder Limited
    Inventors: Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS, Megan CROAL, Hans Åke ERIKSSON, George GOLDSMITH, Molly Tabitha HICKEY, Shaun HURLEY, Ekaterina MALIEVSKAIA, Lindsey MARWOOD, Drummond E-Wen Joe MCCULLOCH, Laurie Emma MEDHURST, Nathan POULSEN, Aslihan SELIMBEYOGLU, Anaïs SOULA, Amanda Tan SHUXIANG, Manon Cecile Elisabeth VERAART, Tobias Patrick WHELAN, Lars Christian WILDE, Stephen WRIGHT
  • PREPARATION OF PSILOCYBIN, DIFFERENT POLYMORPHIC FORMS, INTERMEDIATES, FORMULATIONS AND THEIR USE
    Publication number: 20240199660
    Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
    Type: Application
    Filed: February 5, 2024
    Publication date: June 20, 2024
    Applicant: Compass Pathfinder Limited
    Inventors: Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS
  • PHARMACEUTICALLY ACCEPTABLE SALTS OF PSILOCIN AND USES THEREOF
    Publication number: 20240124398
    Abstract: The present invention composition features pharmaceutically acceptable salts of psilocin and compositions thereof. The pharmaceutically acceptable salts of psilocin may be used to treat a disease or condition, such as a neurological injury, an inflammatory condition, chronic pain, or a psychological condition, in a subject in need thereof.
    Type: Application
    Filed: February 10, 2022
    Publication date: April 18, 2024
    Inventors: David E. NICHOLS, Graham JOHNSON, Hooshang S. ZAVAREH, Claire WOMBWELL, Daniel RIXSON, Peter HADDOW, Carrie SHEARD, Alexander SCHWARZ
  • Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
    Patent number: 11939346
    Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
    Type: Grant
    Filed: April 17, 2023
    Date of Patent: March 26, 2024
    Assignee: Compass Pathfinder Limited
    Inventors: Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols
  • Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin
    Patent number: 11865126
    Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
    Type: Grant
    Filed: June 15, 2023
    Date of Patent: January 9, 2024
    Assignee: Compass Pathfinder Limited
    Inventors: Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols, Megan Croal, Hans Åke Eriksson, George Goldsmith, Molly Tabitha Hickey, Shaun Hurley, Ekaterina Malievskaia, Lindsey Marwood, Drummond E-Wen Joe Mcculloch, Laurie Emma Medhurst, Nathan Poulsen, Aslihan Selimbeyoglu, Anaïs Soula, Amanda Tan Shuxiang, Manon Cecile Elisabeth Veraart, Tobias Patrick Whelan, Lars Christian Wilde, Stephen Wright
  • Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
    Patent number: 11851451
    Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: December 26, 2023
    Assignee: COMPASS PATHFINDER LIMITED
    Inventors: Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols
  • PHARMACEUTICALLY ACCEPTABLE SALTS OF PSILOCIN AND USES THEREOF
    Publication number: 20230357144
    Abstract: The present invention composition features pharmaceutically acceptable salts of psilocin and compositions thereof. The pharmaceutically acceptable salts of psilocin may be used to treat a disease or condition, such as a neurological injury, an inflammatory condition, chronic pain, or a psychological condition, in a subject in need thereof.
    Type: Application
    Filed: May 3, 2023
    Publication date: November 9, 2023
    Inventors: David E. NICHOLS, Graham JOHNSON, Hooshang S. ZAVAREH, Claire WOMBWELL, Daniel RIXSON, Peter HADDOW, Carrie SHEARD, Alexander SCHWARZ
  • METHOD FOR TREATING ANXIETY DISORDERS, HEADACHE DISORDERS, AND EATING DISORDERS WITH PSILOCYBIN
    Publication number: 20230330117
    Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
    Type: Application
    Filed: June 15, 2023
    Publication date: October 19, 2023
    Applicant: Compass Pathfinder Limited
    Inventors: Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS, Megan CROAL, Hans Åke ERIKSSON, George GOLDSMITH, Molly Tabitha HICKEY, Shaun HURLEY, Ekaterina MALIEVSKAIA, Lindsey MARWOOD, Drummond E-Wen Joe MCCULLOCH, Laurie Emma MEDHURST, Nathan POULSEN, Aslihan SELIMBEYOGLU, Anaïs SOULA, Amanda Tan SHUXIANG, Manon Cecile Elisabeth VERAART, Tobias Patrick WHELAN, Lars Christian WILDE, Stephen WRIGHT
  • METHOD OF TREATMENT FOR PSILOCYBIN OR PSILOCIN INFUSION
    Publication number: 20230277568
    Abstract: Methods for treatment for patients suffering from disease or condition are contemplated as including an administration of an intravenous infusion of a pharmaceutically effective amount of psilocybin or psilocin. The intravenous infusion of psilocybin or psilocin may include an additional compound such as a benzodiazepine, preferably lorazepam, administered via a continuous intra-venous infusion. Such methods may be seen to better alleviate the symptoms of psychological conditions, neurological injuries, pain, or inflammatory condition, and may result in reduced need for other medications.
    Type: Application
    Filed: July 12, 2021
    Publication date: September 7, 2023
    Inventors: Ryan Steven BRIDGES, J. Cannon CLIFTON, John Bryan CLIFTON, Neiloufar FAMILY, Emeline L. MAILLET, Shlomi RAZ, David E. NICHOLS, Charles D. NICHOLS
  • Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin
    Patent number: 11738035
    Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
    Type: Grant
    Filed: December 8, 2022
    Date of Patent: August 29, 2023
    Assignee: Compass Pathfinder Limited
    Inventors: Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols, Megan Croal, Hans Åke Eriksson, George Goldsmith, Molly Tabitha Hickey, Shaun Hurley, Ekaterina Malievskaia, Lindsey Marwood, Drummond E-Wen Joe McCulloch, Laurie Emma Medhurst, Nathan Poulsen, Aslihan Selimbeyoglu, Anaïs Soula, Amanda Tan Shuxiang, Manon Cecile Elisabeth Veraart, Tobias Patrick Whelan, Lars Christian Wilde, Stephen Wright
  • PREPARATION OF PSILOCYBIN, DIFFERENT POLYMORPHIC FORMS, INTERMEDIATES, FORMULATIONS AND THEIR USE
    Publication number: 20230250115
    Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
    Type: Application
    Filed: April 17, 2023
    Publication date: August 10, 2023
    Applicants: Compass Pathfinder Limited, Compass Pathfinder Limited
    Inventors: Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS
  • Pharmaceutically acceptable salts of psilocin and uses thereof
    Patent number: 11680043
    Abstract: The present invention composition features pharmaceutically acceptable salts of psilocin and compositions thereof. The pharmaceutically acceptable salts of psilocin may be used to treat a disease or condition, such as a neurological injury, an inflammatory condition, chronic pain, or a psychological condition, in a subject in need thereof.
    Type: Grant
    Filed: March 30, 2022
    Date of Patent: June 20, 2023
    Assignee: Eleusis Therapeutics US, Inc.
    Inventors: David E. Nichols, Graham Johnson, Hooshang S. Zavareh, Claire Wombwell, Daniel Rixson, Peter Haddow, Carrie Sheard, Alexander Schwarz
  • PREPARATION OF PSILOCYBIN, DIFFERENT POLYMORPHIC FORMS, INTERMEDIATES, FORMULATIONS AND THEIR USE
    Publication number: 20230119714
    Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
    Type: Application
    Filed: November 21, 2022
    Publication date: April 20, 2023
    Applicant: COMPASS PATHFINDER LIMITED
    Inventors: Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS
  • METHOD FOR TREATING ANXIETY DISORDERS, HEADACHE DISORDERS, AND EATING DISORDERS WITH PSILOCYBIN
    Publication number: 20230124137
    Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
    Type: Application
    Filed: December 8, 2022
    Publication date: April 20, 2023
    Applicant: COMPASS PATHFINDER LIMITED
    Inventors: Derek John LONDESBROUGH, Christopher BROWN, Julian Scott NORTHEN, Gillian MOORE, Hemant Kashinath PATIL, David E. NICHOLS, Megan CROAL, Hans Åke ERIKSSON, George GOLDSMITH, Molly Tabitha HICKEY, Shaun HURLEY, Ekaterina MALIEVSKAIA, Lindsey MARWOOD, Drummond E-Wen Joe MCCULLOCH, Laurie Emma MEDHURST, Nathan POULSEN, Aslihan SELIMBEYOGLU, Anaïs SOULA, Amanda Tan SHUXIANG, Manon Cecile Elisabeth VERAART, Tobias Patrick WHELAN, Lars Christian WILDE, Stephen WRIGHT
  • Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
    Patent number: 11629159
    Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: April 18, 2023
    Assignee: Compass Pathfinder Limited
    Inventors: Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols
  • Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin
    Patent number: 11564935
    Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
    Type: Grant
    Filed: December 2, 2021
    Date of Patent: January 31, 2023
    Assignee: COMPASS Pathfinder Limited
    Inventors: Derek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols, Megan Croal, Hans Åke Eriksson, George Goldsmith, Molly Tabitha Hickey, Shaun Hurley, Ekaterina Malievskaia, Lindsey Marwood, Drummond E-Wen Joe McCulloch, Laurie Emma Medhurst, Nathan Poulsen, Aslihan Selimbeyoglu, Anaïs Soula, Amanda Tan Shuxiang, Manon Cecile Elisabeth Veraart, Tobias Patrick Whelan, Lars Christian Wilde, Stephen Wright