Abstract: The present disclosure relates generally to methods of using modulators of COT (cancer Osaka thyroid) for treating, stabilizing, or lessening the severity or progression of liver disease, in particular, Nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).

Abstract: Systems, methods, and computer program products to perform an operation to prioritize capability gaps, the operation comprising determining, for each of a plurality of business objectives, a weighted effectiveness, criticality, and differentiation (ECD) score, and determining operation of one or more processors, a priority value for each of a plurality of capability gaps based on: (i) the weighted ECD score of each business objective, and (ii) a degree of support the respective capability gap provides towards fulfilling each business objective, wherein each priority value reflects a degree of importance of a capability subject to the respective capability gap.

Abstract: Method to perform an operation to prioritize capability gaps, the operation comprising determining, for each of a plurality of business objectives, a weighted effectiveness, criticality, and differentiation (ECD) score, and determining operation of one or more processors, a priority value for each of a plurality of capability gaps based on: (i) the weighted ECD score of each business objective, and (ii) a degree of support the respective capability gap provides towards fulfilling each business objective, wherein each priority value reflects a degree of importance of a capability subject to the respective capability gap.

Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO: 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract: The invention provides methods of treatment using retro-inverso peptides derived from interleukin-3 (IL-3) having between 12 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. The peptides of the invention have the same activity as native IL-3 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO: 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract: The invention provides methods of treatment using retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence that is retro-inverso with respect to SEQ ID NO: 1. The peptides of the invention have the same activity as native LIF and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO: 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract: A golf club head and a method of tuning the golf club head. The golf club head includes a body having a front surface, a back surface, a heel end, a toe end, a sole extending between the lower portions of the heel and the toe ends, a top portion extending between the upper portions of the heel and toe ends, and a cavity. One or more magnets are mounted in the cavity such that their distance into the cavity can be adjusted. A detachable face plate having one or more magnets attached to a back surface of the detachable face plate is slidably mated with guides extending from the body. At least two of the magnets are positioned such that the north pole of the magnet in the cavity faces the north pole of a magnet attached to the back surface of the detachable face plate. A repulsive force between the north poles pushes the detachable face plate away from the body and into a stop coupled to the body.

Abstract: A golf club head has a face insert that is supported from beneath by a substrate composed of a plurality of elongate rod elements arranged in a parallel closely packed array. Because the face insert is made of a single material, the resiliency of the face insert itself does not vary across the front surface of the face insert; however, the effective resiliency of the face insert may be varied by varying the resiliency of the substrate. This is accomplished by selecting different materials and/or different overall lengths for the rod elements that comprise the substrate. Use of a substrate comprising a plurality of rod elements permits the effective resiliency of the face insert to be varied without varying the face material.

Abstract: A golf club head has a cavity for receiving a face insert. A first face insert, which is disposed in the cavity, has a front surface that is contoured. A second face insert composed of multiple rod elements is disposed in the cavity on top of the first face insert so that the rod elements are supported by the contoured front surface of the first face insert. Because the first face insert supporting the rod elements is contoured, the individual rod elements are of different lengths and, therefore, exhibit different dynamic responses when striking a golf ball, even when the rod elements are made of the same material.

Abstract: A golf club head has a face insert that is supported from beneath by a substrate composed of a plurality of elongate rod elements arranged in a parallel closely packed array. Because the face insert is made of a single material, the resiliency of the face insert itself does not vary across the front surface of the face insert; however, the effective resiliency of the face insert may be varied by varying the resiliency of the substrate. This is accomplished by selecting different materials and/or different overall lengths for the rod elements that comprise the substrate. Use of a substrate comprising a plurality of rod elements permits the effective resiliency of the face insert to be varied without varying the face material.

Abstract: Retro-inverso peptides derived from interleukin-6 (IL-6) having between 17 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-6 and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.

Abstract: Retro-inverso peptides derived from interleukin-3 (IL-3) having between 12 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-3 and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.

Abstract: Retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native LIF and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.

Abstract: A selectable insert for a golf club head (e.g., for a golf putter) is configured to produce a predetermined frequency response through the use of, for example, a damped single-degree-of-freedom (SDOF) system. A set of such inserts are provided, and one or more inserts from that set is selected in accordance with the response of an individual, for example, an individual's subjective response to the sound of the insert and/or an individual's biomechanical response to the “feel” or discomfort produced by vibrations propagating through the golf club to the individual.

Abstract: A method of making a face mask including the steps of providing a plurality of lengths of Grade 2, commercially pure titanium wire, having a diameter of from about 0.21 to about 0.24 inches; forming each length at room temperature to a desired bend angle by bending the member at room temperature using rotary bending apparatus to a first bend angle that is from about 1.25 to about 1.35 times greater than the desired bend angle; and welding each of the thus formed lengths to at least one other of the lengths in an ambient, oxygen containing environment.

Abstract: A method of making a face mask including the steps of providing a plurality of lengths of Grade 2, commercially pure titanium wire, having a diameter of from about 0.21 to about 0.24 inches; forming each length at room temperature to a desired bend angle by bending the member at room temperature using rotary bending apparatus to a first bend angle that is from about 1.25 to about 1.35 times greater than the desired bend angle; and welding each of the thus formed lengths to at least one other of the lengths in an ambient, oxygen containing environment.

Abstract: A microfilm drying device and method are presented for salvaging and drying microfilm which has become wet due to excessive moisture resulting from high water, floods and the like. The device includes a needle assembly which is slidably affixed within a frame to direct air into the internal compartments of a flexible jacket containing microfilm strips. In another embodiment, a hand held drying device allows air to pass through a series of needles to dry the interior of the flexible jackets.