Abstract: A method of distinguishing between proteinaceous and non-proteinaceous particulates in a fluid sample includes the steps of acquiring a brightfield background image of a membrane filter, introducing a fluid sample onto the membrane filter, acquiring a brightfield image of filtered particles resting on the membrane filter, generating a particle mask based on the brightfield background image and the brightfield image of filtered particles, introducing a fluorescent dye onto the membrane filter, detecting fluorescence on the particle mask, and distinguishing between proteinaceous and non-proteinaceous particulates based on the detected fluorescence. A method for detecting other types of particles, such as polysorbate particles, silicone oil or protein monomers is also disclosed.

Abstract: A method and apparatus that provides a solid state drive that analyzes connection performance during I/O operations and is configured to independently modify connection performance based upon user specified input parameters without the need for host computer management.

Abstract: The present disclosure generally relates to a method for intelligent device initiated SAS Phy PM. Using device internal phy characteristics and future phy usage queue, the device determines optimal SAS Phy PM usage based on a predetermined configuration preference of power versus performance. The device achieves optimal SAS Phy PM Usage by implementing a state machine to manage phy PM states and transitions between the PM states. The device state machine includes capabilities to proactively initiate transitions to partial or slumber PM states, start early wake-up from partial or slumber PM states to mask the associated latency impacts of exiting partial or slumber PM states, and selectively reject host requests to enter a partial or slumber PM state.

Abstract: An optofluidic photoreactor including an optical waveguide having an input, characterized by an evanescent optical field confined along an outer surface of the optical waveguide produced by radiation propagating in the optical waveguide, means for inputting light to the input of the optical waveguide, and a photoactive material disposed substantially only within the evanescent field. A method for optically activating a photoactive material in an optofluidic photoreactor to convert carbon dioxide and water into other molecules that may be useful as a fuel or a chemical feedstock.

Abstract: A method for control of latency information through logical block addressing is described comprising receiving a computer command, performing a read flow operation on a computer buffer memory based on the computer command; populating at least one metadata frame with data based on logical block address latency information; initiating a serial attached data path transfer for one of transmitting and receiving data to the computer drive and transmitting data to a host based on the second latency.

Abstract: In some aspects, the disclosure is directed to methods and systems for controlling a set top box remotely and monitoring its display output. Remote control commands may be intercepted or captured and forwarded over a network as encapsulated serial data or HDMI-CEC, in some implementations. This data may be transmitted over a network to a processing device, sometimes referred to as an HDMI pass-through and streamer device. The HDMI pass-through device may receive the encapsulated serial data via the network and retransmit the data as CEC data over HDMI to the set top box as if it were any other HDMI capable device, such as a television. Thus, the recipient set top box may receive the remote control commands via CEC and treat them as incoming IR commands and act accordingly.

Abstract: Systems, methods, and non-transitory computer-readable media can provide a graphical user interface that includes at least one set of content items that are available for curation, wherein at least one content item in the set is obtained from a social networking system, and wherein each content item is associated with at least one option for exporting the content item. A selection of the option for exporting a first content item, from the set, to a content provider can be received. The first content item can be provided to the content provider for presentation.

Abstract: A method for control of latency information through logical block addressing is described comprising receiving a computer command, performing a read flow operation on a computer buffer memory based on the computer command; populating at least one metadata frame with data based on logical block address latency information; initiating a serial attached data path transfer for one of transmitting and receiving data to the computer drive and transmitting data to a host based on the second latency.

Abstract: A method and apparatus that provides a solid state drive that analyzes connection performance during I/O operations and is configured to independently modify connection performance based upon user specified input parameters without the need for host computer management.

Abstract: A STB, communicatively coupled to a server, receives a web page request when, for example, a URI, is entered into a web browser running in the STB. In response, the STB sends a processing assistance request to the server for processing the entire web page regardless of processing capability of the STB. The STB receives processed information resources or contents associated with the entire web page from the server. The server retrieves information resources or contents associated with the entire web page from a web server based on the received processing assistance request. The server determines content type such as video and/or graphics of the retrieved information resources or contents for corresponding content processing. The server determines content formats supported by the STB for content encoding. The STB decodes the resulting encoded information resources or contents from the server to render the entire web page in the STB.

Abstract: This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

Abstract: A method includes receiving, by a hardware controller of a storage device and from a host device, a command to read data from or write data to a non-volatile memory device of the storage device. The method includes, responsive to receiving the command: initializing, by firmware executing at a processor of the hardware controller, a command to retrieve data from or write data to the non-volatile memory device; determining, by circuit logic of the hardware controller, a time indicative of when the firmware initialized the command; determining, by the circuit logic, a time indicative of when the command terminated; and storing, by the circuit logic and at a latency monitoring cache of the storage device, a timestamp associated with the time indicative of when the command was initialized and a timestamp associated with the time indicative of when the command terminated.

Abstract: A device for detecting the presence of a target in a sample including a first port configured to receive a multi-layered substrate having a sample inlet and a reagent inlet. The sample inlet is connected to a first microfluidic channel and the reagent inlet is connected to both the first microfluidic channel and a second microfluidic channel. The second microfluidic channel has a longer pathway than the first microfluidic channel. A first test strip and a second test strip are each connected to both the first microfluidic channel and the second microfluidic channel, while a third test strip is connected only to the first microfluidic channel. Each test strip includes a conjugate section, a detection section, and a collection section.

Abstract: A method for control of latency information through logical block addressing is described comprising receiving a computer command, performing a read flow operation on a computer buffer memory based on the computer command; populating at least one metadata frame with data based on logical block address latency information; initiating a serial attached data path transfer for one of transmitting and receiving data to the computer drive and transmitting data to a host based on the second latency.

Abstract: The present disclosure provides an advantageous underground enclosure/assembly for housing electrical components. More particularly, the present disclosure provides an underground enclosure/assembly (e.g., handhole/pullbox assembly) that is configured to protect wiring connections and provide access to those connections for initial installation, and later for maintenance/alteration. The present disclosure provides for a cylindrical body and a frame with a lip feature to interface with the cylindrical body to enhance the durability and to assist in maintaining the circularity of the cylindrical body. The advantageous frame provides for a feature (e.g., a notch) to integrate fill materials with the frame. The frame further includes features for interfacing a cover.

Abstract: Disclosed is a high resolution intravascular ultrasound imaging system including a catheter with a rotatable imaging assembly and an image processor. The image processor in turn features a pulser configured to energize the ultrasound transducer of the rotatable imaging assembly with a multi-frequency ultrasound waveform signal. The image processor further contains a receiver configured to decompose received ultrasound energy as reflected by the target vessel into a plurality of individual subband signals, individually process these signals and reconstitute these signals into a high resolution image of the blood vessel. The IVUS system of the invention may be useful in characterizing cap thickness of vulnerable plaques or other detailed studies of blood vessels.

Abstract: A method for characterizing an interaction between a first particle and a second particle is provided. The method includes the steps of: (i) providing an optical trap system including a photonics-based trap, a light source, and a camera; (ii) optically trapping, using the photonics-based trap, the first particle; (iii) obtaining a first measurement of a trap stiffness of the photonics-based trap; (iv) introducing the second particle to the optically trapped particle; (v) incubating the first and second particles under conditions suitable for an interaction between the first and second particles; (vi) obtaining a second measurement of the trap stiffness of the photonics-based trap after the incubation; and (vii) determining, using the first measurement of trap stiffness and the second measurement of trap stiffness, a property of the interaction between the first particle and the second particle.

Abstract: Disclosed is a high resolution intravascular ultrasound imaging system including a catheter with a rotatable imaging assembly and an image processor. The image processor in turn features a pulser configured to energize the ultrasound transducer of the rotatable imaging assembly with a multi-frequency ultrasound waveform signal. The image processor further contains a receiver configured to decompose received ultrasound energy as reflected by the target vessel into a plurality of individual subband signals, individually process these signals and reconstitute these signals into a high resolution image of the blood vessel. The IVUS system of the invention may be useful in characterizing cap thickness of vulnerable plaques or other detailed studies of blood vessels.

Abstract: The present invention relates to a competitive diagnostic assay strip for detection of a target molecule in a sample. The strip includes an elongated substrate extending between a first end at which the sample is applied to the strip and a second end at which results of the assay can be assessed. A first layer is supported on the substrate for receiving, absorbing, and filtering a liquid sample. A second layer is supported on the substrate, wherein the second layer comprising a mobile labelled specific binding partner of a target molecule. A third layer is supported on the substrate, the third layer comprising a test region and a control region separated from the test region. The test region has immobilized target molecules. Yet another aspect of the present invention relates to a method of conducting a diagnostic assay. The method includes providing a competitive diagnostic assay strip in accordance with the present invention.

Abstract: The present invention relates to a microfluidic device, a microfluidic system, and methods for tracking single cells, multiple cells, single cell lineages, and multiple cell lineages in series and/or in parallel. The microfluidic device comprises a substrate having one microfluidic channel formed therein or a plurality of microfluidic channels formed therein and arranged in parallel. The microfluidic system comprises: a microfluidic device according to the present invention; a cell loading reservoir in fluid communication with the inlet end of each microfluidic channel of the microfluidic device; and an outlet reservoir in fluid communication with the outlet end of each microfluidic channel of the microfluidic device. The present invention also relates to a high throughput microfluidic system and a kit for tracking single cells and/or single cell lineages.