Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A multispectral sensing device includes a first die, including silicon, which is patterned to define a first array of sensor elements, which output first electrical signals in response to optical radiation that is incident on the device in a band of wavelengths less than 1000 nm that is incident on the front side of the first die. A second die has its first side bonded to the back side of the first die and includes a photosensitive material and is patterned to define a second array of sensor elements, which output second electrical signals in response to the optical radiation that is incident on the device in a second band of wavelengths greater than 1000 nm that passes through the first die and is incident on the first side of the second die. Readout circuitry reads the first electrical signals and the second electrical signals serially out of the device.

Abstract: Personal care compositions and methods for improving skin are disclosed. A personal care composition according to an aspect of the disclosure that may be in the form of an intimate care product and include from about 0.5 to about 7 wt. % of a post-biotic blend; optionally, from about 0.1 to about 5 wt. % of a polysaccharide; optionally, from about 0.01 to about 12 wt. % of a fatty alcohol, wherein all weight percentages are based on the total weight of the personal care composition. A method according to an aspect of the disclosure may include applying an intimate care composition to a section of skin; rinsing the section of skin; and applying a lotion composition to the section of skin.

Abstract: Described herein are personal care compositions (e.g., bar soaps) that may include from about 0.1 to about 5 wt. % of a polysaccharide; from about 0.01 to about 12 wt. % of a fatty alcohol; and from about 0.5 to about 7 wt. % of a post-biotic blend, wherein all weight percentages are based on the total weight of the personal care composition. Methods of making and using the personal care compositions are also described herein.

Abstract: Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

Abstract: A method for controlling an electronic power steering system may include receiving, at an electronic power steering controller, at least one signal from at least one sensor and generating, by the electronic power steering controller using the at least one signal, a first autonomous steering command. The method may also include receiving, from a domain controller at the electronic power steering controller, a second autonomous steering command and comparing, by the electronic power steering controller, the first autonomous steering command and the second autonomous steering command. The method may also include selectively controlling, by the electronic power steering controller, the electronic power steering system using one of the first autonomous steering command and the second autonomous steering command, based on the comparison of the first autonomous steering command and the second autonomous steering command.

Abstract: A method for controlling an electronic power steering system may include receiving, at an electronic power steering controller, at least one signal from at least one sensor and generating, by the electronic power steering controller using the at least one signal, a first autonomous steering command. The method may also include receiving, from a domain controller at the electronic power steering controller, a second autonomous steering command and comparing, by the electronic power steering controller, the first autonomous steering command and the second autonomous steering command. The method may also include selectively controlling, by the electronic power steering controller, the electronic power steering system using one of the first autonomous steering command and the second autonomous steering command, based on the comparison of the first autonomous steering command and the second autonomous steering command.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for a content platform that receives a request to provide a digital component. The request includes information about users to which the digital component is directed. Futurized queries are obtained from serving logs of a serving system that is configured to execute an existing digital component using serving code that directs digital content to the set of users. The futurized queries are loaded as data structures in memory of a forecasting system. The system uses an instruction set derived from the serving code to determine that similarity between the particular futurized query and the request exceeds a threshold similarity. The system then generates a forecast output as a response to the request based on futurized queries that exceed the threshold similarity. The forecast output includes data describing future provision of the digital component.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for a content platform that receives a request to provide a digital component. The request includes information about users to which the digital component is directed. Futurized queries are obtained from serving logs of a serving system that is configured to execute an existing digital component using serving code that directs digital content to the set of users. The futurized queries are loaded as data structures in memory of a forecasting system. The system uses an instruction set derived from the serving code to determine that similarity between the particular futurized query and the request exceeds a threshold similarity. The system then generates a forecast output as a response to the request based on futurized queries that exceed the threshold similarity. The forecast output includes data describing future provision of the digital component.

Abstract: An eddy current probe comprises a first planar coil, a second planar coil and a flexible substrate. The first coil comprises a first conductor having a spiral geometry, and the second coil comprises a second conductor having a spiral geometry. The first conductor is arranged concentrically with the second conductor, with the first conductor being juxtaposed with the second conductor, and the concentrically arranged first and second conductors are embedded within the flexible substrate.

Abstract: A system for synchronizing unstructured documents includes sub-nodes (110, 120, 130) and a network connecting the sub-nodes together. Each sub-node includes a database server (113, 123, 133), an FTP (file transfer protocol) server, and client computers (111, 121, 131). The database server includes a summary table (400) for storing a summary of all unstructured documents, and has the function of synchronizing with summary tables stored in other sub-nodes. The FTP server stores unstructured documents, and has the function of downloading unstructured documents from the FTP servers of other sub-nodes. Each client computer includes a client proxy. The client proxy includes a database processing module for generating instructions on updating, searching, and deleting data stored in the database server, a file processing module for generating instructions on downloading unstructured documents from the FTP servers of other sub-nodes, and a client processing module for receiving sync orders from users.

Abstract: Embodiments of the invention include a system for displaying an audit diagram. The system includes a monitor capable of electronically displaying the audit diagram. The monitor includes a text equivalent constructed from an input text, and a conversion representation including an operator indicator, a result arrow, and a rule arrow.

Abstract: The invention described herein includes a method of analyzing a population of individuals. The method includes entering the population of individuals into an information processing system. Each individual includes one or more properties. Each property includes one or more conditions and a numerical value. The method also includes displaying the population of the individuals in a visual map. The visual map is divided into parallel property zones of properties. The individuals are represented in the map as parallel lines wherein the lines are orthogonal to the property zones.

Abstract: Nonalcoholic steatohepatitis (NASH) is a disease of the liver characterized by inflammation and damage to the liver cells. Typically, steatohepatitis involves inflammation of the liver related to fat accumulation, and mimics alcoholic hepatitis but is observed in patients who seldom or never consume alcohol. Nonalcoholic steatohepatitis can lead to serious liver damage, and ultimately cirrhosis. The present invention provides methods and compositions useful for the treatment or alleviation of nonalcoholic steatohepatitis and the pharmaceutical formulations for their administration to a human. Specifically, compositions comprised of lecithin, antioxidants and vitamin B complex are administered parenterally, most preferably by oral administration. Specific therapeutic formulations include admixtures of these compounds and specific dosage formulations include daily oral administrations of these compounds in tablet or powder forms.

Abstract: Systems, methods, and structures are described to support enhanced population analysis are discussed. The population includes individuals with each individual including a set of properties. The system of the present invention is useful for exploring population structure including individuals with missing values, individuals that are documents in databases, and individuals that are products and services sold using a computer display.

Abstract: A system for synchronizing distributed stored documents includes a core-node (110), a plurality of branch-nodes (120, 130), and a network (140) connecting the core-node with the branch-nodes. Each branch-node includes: a branch-database server (123, 133) for storing a summary of all distributed stored documents, wherein the summary can be updated in accordance with a sync message received from the core-node; and a branch-FTP (File Transfer Protocol) server for storing the distributed stored documents, the branch-FTP server having the function of exchanging documents with the core-node. The core-node includes a core-database server (113), a core-FTP server (309), and an application server (310). The core-database server stores a summary of all distributed stored documents. The core-FTP server is used for storing the distributed stored documents. The application server comprises a sync controlling module (313) that controls data exchange between the core-FTP server and the branch-FTP servers.

Abstract: Systems, methods, and structures are described that enhance career analysis. Various embodiments include a storage system of information in which the past histories of people are organized so that users of the system can predict the likelihood of a future outcome such as salary earned upon the completion of an activity such as a job training course. Various embodiments can be used for other predictions such as the types of job and/or training history which are most likely to lead to a particular career and other characteristics of organizations and population such as buying patterns and the quality of educational institutions.

Abstract: Nonalcoholic steatohepatitis (NASH) is a disease of the liver characterized by inflammation and damage to the liver cells. Typically, steatohepatitis involves inflammation of the liver related to fat accumulation, and mimics alcoholic hepatitis but is observed in patients who seldom or never consume alcohol. Nonalcoholic steatohepatitis can lead to serious liver damage, and ultimately cirrhosis. The present invention provides methods and compositions useful for the treatment or alleviation of nonalcoholic steatohepatitis and the pharmaceutical formulations for their administration to a human. Specifically, compositions comprised of lecithin, antioxidants and vitamin B complex are administered parenterally, most preferably by oral administration. Specific therapeutic formulations include admixtures of these compounds and specific dosage formulations include daily oral administrations of these compounds in tablet or powder forms.

Abstract: A system for automatically notifying payment includes a database server (1), an application server (2), a network (3), and a plurality of client computers (4) located in various different places. The database server stores customer information and corresponding payment information. The application server generates payment notifications according to the customer information and corresponding payment information stored in the database server. The application server can select suitable languages and set appropriate times for transmission of the payment notifications, according to the customers' particular working circumstances. The payment notifications are automatically duplicated and encrypted before sending to the relevant customers. The application server sends the payment notifications to respective customers at the client computers. A related method is also disclosed.