Abstract: Provided are heterobifunctional degrader compounds that bind with cyclin dependent kinase 9 (CDK9) and E3 ubiquitin ligase. Also provided are methods of treating a subject for a CDK9-mediated disease by administering a therapeutically effective dose of a pharmaceutical composition including the heterobifunctional degrader.

Abstract: Provided are polymorphic and salt forms of (1S,3S)—N1—(5-(pentan-3-yl)pyrazolo[1,5-?]pyrimidin-7-yl) cyclopentane-1,3-diamine. Provided are polymorphic forms of the free base of the compound along with polymorphic forms of salts of the compound, including tosylate salts, oxalate salts, fumarate salts, camsylate salts, citrate salts, hydrochloride salts, and naphthalene-1,5-disulfonic acid salts. Such forms have been characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), and thermogravimetric analysis coupled to mass spectrometry (TGA-MS). Such polymorphic and salt forms can have desirable solubility, dissolution, and pharmacokinetic properties.

Abstract: A method can comprise a first player and an opponent conducting turns during a game. A first player's turn can include the first player activating cards and/or effectuating effects of one or more of the first player's active cards, playing active cards such as causing an active champion card to raid the opponent, and/or associating a number of victory points with a first player's raiding active champion card equal to the raiding active champion's raid value. The opponent's turn can include the opponent activating cards and/or effectuating effects of one or more of the opponent's active cards, and/or playing active cards such as causing an active opponent champion card to raid the first player or attack the first player's raiding active champion card. The victory points associated with the first player's raiding active champion card can be reduced by the raid value of an attacking opponent champion card.

Abstract: A method for controlling phased transfer of multiple spacecraft from a separation orbit to a target orbit includes, while maintaining an in-phase relationship of the spacecraft relative to each other within the separation orbit, computing, via a control system, respective desired trajectories for a lead spacecraft and two or more follower spacecraft to reach the target orbit. The method includes establishing a constant phase offset between the spacecraft in mean anomaly of the separation orbit. During a series of transfer orbits of the spacecraft from the separation orbit to the target orbit, the method includes applying the desired trajectories via the control system such that the constant phase offset is maintained and the follower spacecraft are simultaneously transferred to the target orbit in-phase with the lead spacecraft. The control system includes a processor and computer-readable storage medium programmed with instructions for performing the method.

Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: Various data bus monitoring, analysis, and logging systems, devices, and methods are described herein. In one example, an apparatus includes a first circuit configured to monitor first packets among traffic carried by one or more first directional lanes of a communication link established between a host and one or more endpoint devices and determine header information for the first packets. The apparatus includes a second circuit configured to detect second packets among traffic carried by one or more second directional lanes of the communication link based at least in part on the header information determined for the first packets. The apparatus includes an analysis element configured to establish transaction metadata comprising properties of transactions on the communication link based at least on correlations among the first packets and the second packets.

Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: A dispenser for a product in stick form includes a product stick carrier (210), an outer sleeve (206) and a product concealing sleeve (208). The product stick carrier (210) includes a product stick support (225). The outer sleeve (206) is a cylindrical tube disposed radially outwardly of the product stick carrier (210). The product stick carrier (210) is fixed relative to the outer sleeve (206). The product concealing sleeve (208) is a cylindrical tube disposed radially inwardly of the outer sleeve (206) and is retractable from a first, fully extended position relative to the outer sleeve (206) and product stick carrier (210) for concealing a product stick (204) supported by the product stick support (225) in use in order to expose the product stick (204). The product concealing sleeve (208) is disposed radially outwardly of the product stick carrier (210) between the product stick carrier (210) and the outer sleeve (206).

Abstract: Various data bus monitoring, analysis, and logging systems, devices, and methods are described herein. In one example, an apparatus includes a first circuit configured to monitor first packets among traffic carried by one or more first directional lanes of a communication link established between a host and one or more endpoint devices and determine header information for the first packets. The apparatus includes a second circuit configured to detect second packets among traffic carried by one or more second directional lanes of the communication link based at least in part on the header information determined for the first packets. The apparatus includes an analysis element configured to establish transaction metadata comprising properties of transactions on the communication link based at least on correlations among the first packets and the second packets.

Abstract: Various data bus monitoring, analysis, and logging systems, devices, and methods are described herein. In one example, an apparatus includes a first circuit configured to monitor first packets among traffic carried by one or more first directional lanes of a communication link established between a host and one or more endpoint devices and determine header information for the first packets. The apparatus includes a second circuit configured to detect second packets among traffic carried by one or more second directional lanes of the communication link based at least in part on the header information determined for the first packets. The apparatus includes an analysis element configured to establish transaction metadata comprising properties of transactions on the communication link based at least on correlations among the first packets and the second packets.

Abstract: A dispenser (2) for a product in stick form comprises: a tubular body (4) having a longitudinal axis (A), the tubular body (4) including a tubular base part (6) and a removable cap (8) for closing an open end of the tubular base part (6). The tubular base part (6) comprises an outer tube (20) made from a paper-based or card-based material such as paperboard or cardboard and having an axially extending helical slot (30) formed in a radially inner surface (36) thereof, an inner tube (22) received within the outer tube (20) and made from a paper-based or card-based material such as paperboard or cardboard and having an axially extending slot (40) formed therethrough and a base (24) made from a paper-based or card-based material such as paperboard or cardboard which is rotatable about the longitudinal axis (A) relative to the outer tube (20) and to which the inner tube (22) is fixed so as to be rotatable therewith relative to the outer tube.

Abstract: Systems and methods for blockchain-based secure storage are disclosed. In one embodiment, in an information processing apparatus comprising at least one computer processor, a method for blockchain-based secure storage may include: (1) receiving a plurality of data files from a data file source; (2) bundling the plurality of data files into a package; (3) generating a first hash for each file name for each of the plurality of data files, and a second hash for contents of each of the plurality of data files; (4) generating a block comprising the first hash, the second hash, and a reference to a prior block; (5) encrypting each of the plurality of data files in the package; (6) sending the plurality of packages to a storage provider; and (7) committing the block to a distributed ledger.

Abstract: Various data bus monitoring, analysis, and logging systems, devices, and methods are described herein. In one example, an apparatus includes a first circuit configured to monitor first packets among traffic carried by one or more first directional lanes of a communication link established between a host and one or more endpoint devices and determine header information for the first packets. The apparatus includes a second circuit configured to detect second packets among traffic carried by one or more second directional lanes of the communication link based at least in part on the header information determined for the first packets. The apparatus includes an analysis element configured to establish transaction metadata comprising properties of transactions on the communication link based at least on correlations among the first packets and the second packets.

Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.

Abstract: Systems and methods for blockchain-based secure storage are disclosed. In one embodiment, in an information processing apparatus comprising at least one computer processor, a method for blockchain-based secure storage may include: (1) receiving a plurality of data files from a data file source; (2) bundling the plurality of data files into a package; (3) generating a first hash for each file name for each of the plurality of data files, and a second hash for contents of each of the plurality of data files; (4) generating a block comprising the first hash, the second hash, and a reference to a prior block; (5) encrypting each of the plurality of data files in the package; (6) sending the plurality of packages to a storage provider; and (7) committing the block to a distributed ledger.

Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.