Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: An audio system with a loudspeaker configured to create an audio output, a sensor configured to detect at least the presence of at least one person at a position relative to the loudspeaker, and a processor configured to cause the loudspeaker to alter the audio output based on the position of the at least one person relative to the loudspeaker. Altering of the audio output includes adjusting at least one of a volume, a time delay, an equalization, or a radiation pattern of the audio output.

Abstract: Various data bus monitoring, analysis, and logging systems, devices, and methods are described herein. In one example, an apparatus includes a first circuit configured to monitor first packets among traffic carried by one or more first directional lanes of a communication link established between a host and one or more endpoint devices and determine header information for the first packets. The apparatus includes a second circuit configured to detect second packets among traffic carried by one or more second directional lanes of the communication link based at least in part on the header information determined for the first packets. The apparatus includes an analysis element configured to establish transaction metadata comprising properties of transactions on the communication link based at least on correlations among the first packets and the second packets.

Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: A dispenser for a product in stick form includes a product stick carrier (210), an outer sleeve (206) and a product concealing sleeve (208). The product stick carrier (210) includes a product stick support (225). The outer sleeve (206) is a cylindrical tube disposed radially outwardly of the product stick carrier (210). The product stick carrier (210) is fixed relative to the outer sleeve (206). The product concealing sleeve (208) is a cylindrical tube disposed radially inwardly of the outer sleeve (206) and is retractable from a first, fully extended position relative to the outer sleeve (206) and product stick carrier (210) for concealing a product stick (204) supported by the product stick support (225) in use in order to expose the product stick (204). The product concealing sleeve (208) is disposed radially outwardly of the product stick carrier (210) between the product stick carrier (210) and the outer sleeve (206).

Abstract: Various data bus monitoring, analysis, and logging systems, devices, and methods are described herein. In one example, an apparatus includes a first circuit configured to monitor first packets among traffic carried by one or more first directional lanes of a communication link established between a host and one or more endpoint devices and determine header information for the first packets. The apparatus includes a second circuit configured to detect second packets among traffic carried by one or more second directional lanes of the communication link based at least in part on the header information determined for the first packets. The apparatus includes an analysis element configured to establish transaction metadata comprising properties of transactions on the communication link based at least on correlations among the first packets and the second packets.

Abstract: Various data bus monitoring, analysis, and logging systems, devices, and methods are described herein. In one example, an apparatus includes a first circuit configured to monitor first packets among traffic carried by one or more first directional lanes of a communication link established between a host and one or more endpoint devices and determine header information for the first packets. The apparatus includes a second circuit configured to detect second packets among traffic carried by one or more second directional lanes of the communication link based at least in part on the header information determined for the first packets. The apparatus includes an analysis element configured to establish transaction metadata comprising properties of transactions on the communication link based at least on correlations among the first packets and the second packets.

Abstract: A dispenser (2) for a product in stick form comprises: a tubular body (4) having a longitudinal axis (A), the tubular body (4) including a tubular base part (6) and a removable cap (8) for closing an open end of the tubular base part (6). The tubular base part (6) comprises an outer tube (20) made from a paper-based or card-based material such as paperboard or cardboard and having an axially extending helical slot (30) formed in a radially inner surface (36) thereof, an inner tube (22) received within the outer tube (20) and made from a paper-based or card-based material such as paperboard or cardboard and having an axially extending slot (40) formed therethrough and a base (24) made from a paper-based or card-based material such as paperboard or cardboard which is rotatable about the longitudinal axis (A) relative to the outer tube (20) and to which the inner tube (22) is fixed so as to be rotatable therewith relative to the outer tube.

Abstract: Systems and methods for blockchain-based secure storage are disclosed. In one embodiment, in an information processing apparatus comprising at least one computer processor, a method for blockchain-based secure storage may include: (1) receiving a plurality of data files from a data file source; (2) bundling the plurality of data files into a package; (3) generating a first hash for each file name for each of the plurality of data files, and a second hash for contents of each of the plurality of data files; (4) generating a block comprising the first hash, the second hash, and a reference to a prior block; (5) encrypting each of the plurality of data files in the package; (6) sending the plurality of packages to a storage provider; and (7) committing the block to a distributed ledger.

Abstract: A system includes a first device having a handle, a head coupled to the handle, a bumper supported by a first end of the head and adapted to be used to strike a patient tendon, a force sensor coupled to the bumper and adapted to generate force data in response to force encountered by the bumper and to generate force data, a first accelerometer coupled to generate head acceleration data in response to movement of the head, and first circuitry to capture the force data and acceleration data. The system may further include second device having a housing adapted to be coupled to the patient limb, a second accelerometer supported by the housing to generate limb acceleration data, and second circuitry to capture the acceleration data.

Abstract: Various data bus monitoring, analysis, and logging systems, devices, and methods are described herein. In one example, an apparatus includes a first circuit configured to monitor first packets among traffic carried by one or more first directional lanes of a communication link established between a host and one or more endpoint devices and determine header information for the first packets. The apparatus includes a second circuit configured to detect second packets among traffic carried by one or more second directional lanes of the communication link based at least in part on the header information determined for the first packets. The apparatus includes an analysis element configured to establish transaction metadata comprising properties of transactions on the communication link based at least on correlations among the first packets and the second packets.

Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.

Abstract: In a method and apparatus, an electrical load is disposed across an electric power source. First and second electrical components are disposed between first and second terminals, respectively, and the load and power source. The first electrical component is configured so that the first component passes at most a low level electric current to the first terminal upon a short circuit condition. The second electrical component is configured so that the second component passes at most a low level electric current to the second terminal upon a short circuit condition.

Abstract: In a method and apparatus, an electrical load is disposed across an electric power source. First and second electrical components are disposed between first and second terminals, respectively, and the load and power source. An open circuit is defined between the first and second terminals in absence of a test meter. The first electrical component is configured so that the first component passes at most a low level electric current to the first terminal upon a short circuit condition. The second electrical component is configured so that the second component passes at most a low level electric current to the second terminal upon a short circuit condition.

Abstract: Systems and methods for blockchain-based secure storage are disclosed. In one embodiment, in an information processing apparatus comprising at least one computer processor, a method for blockchain-based secure storage may include: (1) receiving a plurality of data files from a data file source; (2) bundling the plurality of data files into a package; (3) generating a first hash for each file name for each of the plurality of data files, and a second hash for contents of each of the plurality of data files; (4) generating a block comprising the first hash, the second hash, and a reference to a prior block; (5) encrypting each of the plurality of data files in the package; (6) sending the plurality of packages to a storage provider; and (7) committing the block to a distributed ledger.

Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: A solar monitoring system for measuring solar radiation intensity comprising a tracking unit having two-axis movement comprising, head mounted with first and second irradiation measuring units, and a controller. The first irradiation measuring unit comprises a direct normal irradiance (DNI) sensor and the second irradiation measuring unit includes a diffuse horizontal irradiance (DHI) sensor and a global horizontal irradiance (GHI) sensor. The controller receives inputs from the sensors or a software program configured to control orientation of the image capturing head so that the DNI sensor is always exposed to the sun, and the shading disc is always directly between the DHI sensor and the sun.