Patents by Inventor David G. Hangauer

David G. Hangauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biaryl Compositions and Methods for Modulating a Kinase Cascade
    Publication number: 20120270874
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful for methods of protecting against or treating hearing loss, osteoporosis, cell proliferative disorders, obesity, diabetes, eye disease, stroke, atherosclerosis, neuropathic pain or hepatitis B.
    Type: Application
    Filed: July 3, 2012
    Publication date: October 25, 2012
    Inventor: David G. Hangauer, JR.
  • Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
    Patent number: 8293739
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy) phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: October 23, 2012
    Assignee: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, Jr., Daniel Coughlin, Jonathan Gale, Jeremy A. Cody, Debasis Patra, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
  • Biaryl compositions and methods for modulating a kinase cascade
    Patent number: 8236799
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful for methods of protecting against or treating hearing loss, osteoporosis, cell proliferative disorders, obesity, diabetes, eye disease, stroke, atherosclerosis, neuropathic pain or hepatitis B.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: August 7, 2012
    Assignee: Kinex Pharmaceuticals, LLC
    Inventor: David G. Hangauer, Jr.
  • Benzisoxazole piperidine compounds and methods of use thereof
    Patent number: 8129410
    Abstract: The invention includes benzisoxazole piperidine compositions and methods of using them for modulating sleep.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: March 6, 2012
    Assignee: Hypnion, Inc.
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar
  • Compositions and methods for modulating a kinase cascade
    Patent number: 8124605
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: February 28, 2012
    Assignee: Kinex Pharmaceuticals, LLC
    Inventor: David G. Hangauer, Jr.
  • Loxapine analogs and methods of use thereof
    Patent number: 8101596
    Abstract: The invention relates to novel compounds and methods of using them for modulating sleep.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: January 24, 2012
    Assignee: Hypnion Inc.
    Inventors: Dale M. Edgar, David G. Hangauer, Michael Solomon
  • Protein kinase and phosphatase inhibitors
    Patent number: 8088768
    Abstract: The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, Type II diabetes, and obesity.
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: January 3, 2012
    Assignee: The Research Foundation of The State University of New York
    Inventors: David G. Hangauer, Jr., Moustafa E. El-Araby, Karen L. Milkiewicz
  • Benzisoxazole piperazine compounds and methods of use thereof
    Patent number: 8088778
    Abstract: The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: January 3, 2012
    Assignee: Hypnion, Inc.
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar
  • COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER
    Publication number: 20110281872
    Abstract: The invention relates to compositions and methods for the treatment and prevention of cancer and other cell proliferative disorders.
    Type: Application
    Filed: March 11, 2011
    Publication date: November 17, 2011
    Applicant: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, JR., Michael J. Ciesielski, Robert A. Fenstermaker
  • BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE
    Publication number: 20110237586
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt thereof The compounds of the invention are useful for methods of protecting against or treating hearing loss, osteoporosis, cell proliferative disorders, obesity, diabetes, eye disease, stroke, atherosclerosis, neuropathic pain or hepatitis B.
    Type: Application
    Filed: June 3, 2011
    Publication date: September 29, 2011
    Applicant: Kinex Pharmaceuticals, LLC
    Inventor: David G. Hangauer, JR.
  • Compositions and methods of treating cell proliferation disorders
    Patent number: 8003641
    Abstract: The invention relates to compounds and methods for treating cell proliferation disorders.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: August 23, 2011
    Assignee: Kinex Pharmaceuticals, LLC
    Inventor: David G. Hangauer, Jr.
  • Process for the Preparation of Compositions for Modulating a Kinase Cascade and Methods of Use Thereof
    Publication number: 20110201611
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
    Type: Application
    Filed: April 26, 2011
    Publication date: August 18, 2011
    Applicant: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, JR., Daniel Coughlin, Jonathan Gale, Jeremy A. Cody, Debasis Patra, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
  • Compositions for Modulating a Kinase Cascade and Methods of Use Thereof
    Publication number: 20110201612
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.
    Type: Application
    Filed: April 26, 2011
    Publication date: August 18, 2011
    Applicant: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, JR., Debasis Patra, Jeremy A. Cody, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
  • Azepans and methods for making and using same
    Patent number: 7968708
    Abstract: Disclosed are compounds having the formula: wherein Z1 is an alkylene moiety; Q is a carboxylic acid derivative; and R1 and R2 are the same or different and are selected from the group consisting of alkyl, aryl, alkylcarbonyl, arylcarbonyl, hydroxycarbonyl, and alkoxycarbonyl or R1 and R2, taken together with the nitrogen atom to which they are bound, form a ring. Also disclosed are compounds having the formula: wherein Z1 is an alkylene moiety; Q is a carboxylic acid derivative; and R13 is selected from the group consisting of alkyl and aryl. The compounds can be used to modulate cell proliferation and/or apoptosis, for example, in the treatment of cancers and other proliferative diseases, disorders, and conditions.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: June 28, 2011
    Assignees: The Research Foundation of State University of New York, Health Research Inc.
    Inventors: David G. Hangauer, Fengzhi Li, Taher Hegab, Xiang Ling
  • Biaryl compositions and methods for modulating a kinase cascade
    Patent number: 7968574
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful for methods of protecting against or treating hearing loss, osteoporosis, cell proliferative disorders, obesity, diabetes, eye disease, stroke, atherosclerosis, neuropathic pain or hepatitis B.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: June 28, 2011
    Assignee: Kinex Pharmaceuticals, LLC
    Inventor: David G. Hangauer, Jr.
  • Bicyclic compositions and methods for modulating a kinase cascade
    Publication number: 20110136807
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
    Type: Application
    Filed: June 29, 2007
    Publication date: June 9, 2011
    Applicant: Kinex Pharmaceuticals, LLC
    Inventor: David G. Hangauer, JR.
  • Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
    Patent number: 7939529
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: May 10, 2011
    Assignee: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, Jr., Daniel Coughlin, Jonathan Gale, Jeremy A. Cody, Debasis Patra, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
  • Compositions for modulating a kinase cascade and methods of use thereof
    Patent number: 7935697
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: May 3, 2011
    Assignee: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, Jr., Debasis Patra, Jeremy A. Cody, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
  • Compositions and Methods of Treating Cell Proliferation Disorders
    Publication number: 20110065705
    Abstract: The invention relates to compounds and methods for treating cell proliferation disorders.
    Type: Application
    Filed: November 19, 2010
    Publication date: March 17, 2011
    Inventor: David G. Hangauer, JR.
  • Kinase inhibitors
    Patent number: 7901894
    Abstract: The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced using the method of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, atherosclerosis, or immune system activity.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: March 8, 2011
    Assignee: The Research Foundation of State University of New York
    Inventors: David G. Hangauer, Karen L. Milkiewicz