Patents by Inventor David G. Hangauer

David G. Hangauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN KINASE AND PHOSPHATASE INHIBITORS
    Publication number: 20110028474
    Abstract: The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, Type II diabetes, and obesity.
    Type: Application
    Filed: August 10, 2010
    Publication date: February 3, 2011
    Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
    Inventors: David G. Hangauer, JR., Moustafa E. El-Araby, Karen L. Milkiewicz
  • Composition and methods for modulating a kinase cascade
    Patent number: 7851470
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: December 14, 2010
    Assignee: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, Jr., Daniel Coughlin, Jonathan Gale, Jeremy A. Cody, Debasis Patra
  • Bicyclic compositions and methods for modulating a kinase cascade
    Patent number: 7838542
    Abstract: The invention relates to compounds of the class of 2-carboxamide substituted indoles and methods for modulating one or more components of a kinase cascade. The compounds of the invention are useful for osteoporosis, hepatitis B, opthalmic disease, diabetes, athrosclerosis, obesity, chronic neuropathic pain, and stroke.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: November 23, 2010
    Assignee: Kinex Pharmaceuticals, LLC
    Inventor: David G. Hangauer, Jr.
  • PHARMACEUTICAL COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF
    Publication number: 20100278776
    Abstract: The invention relates to a pharmaceutical composition comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: October 20, 2008
    Publication date: November 4, 2010
    Applicant: Kinex Pharmaceuticals, LLC
    Inventor: David G. Hangauer, JR.
  • BIARYL ACETAMIDE DERIVATIVES AS MODULATORS OF THE KINASE CASCADE FOR THE TREATMENT OF HEARING LOSS, OSTEOPOROSIS AND CELL PROLIFERATION DISORDERS
    Publication number: 20100256147
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
    Type: Application
    Filed: April 14, 2008
    Publication date: October 7, 2010
    Inventor: David G. Hangauer, JR.
  • BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE
    Publication number: 20100249130
    Abstract: The invention relates to compounds of formula IB and methods for modulating one or more components of a kinase cascade using these compounds.
    Type: Application
    Filed: April 14, 2008
    Publication date: September 30, 2010
    Applicant: Kinex Pharmaceuticals, LLC
    Inventor: David G. Hangauer, JR.
  • Protein kinase and phosphatase inhibitors and methods for designing them
    Patent number: 7772216
    Abstract: The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, Type II diabetes, and obesity.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: August 10, 2010
    Assignee: The Research Foundation of State University of New York
    Inventors: David G. Hangauer, Jr., Moustafa E. El-Araby, Karen L. Milkiewicz
  • Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds
    Patent number: 7662750
    Abstract: The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of identifying a protein-protein interaction antagonist. The method first involves providing a compound as described herein. Next, the compound is contacted with interacting proteins of a protein-protein interaction target complex, whereby the compound is allowed to compete with the interacting proteins. Then, the activity of the compound for inhibiting formation of the protein-protein interaction target complex is measured. Finally, the compound that inhibits formation of the protein-protein interaction target complex is identified as a protein-protein interaction antagonist. Also disclosed is a method for modulating a protein-protein interaction.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: February 16, 2010
    Assignees: The Research Foundation of State University of New York, Roswell Park Cancer Institute
    Inventors: David G. Hangauer, Tao Ji, Madison Lee, Steven Pruitt
  • COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF
    Publication number: 20090318450
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.
    Type: Application
    Filed: May 19, 2009
    Publication date: December 24, 2009
    Applicant: Kinex Pharmaceuticals, LLC
    Inventors: David G. Hangauer, JR., Debasis Patra, Jeremy A. Cody, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
  • Loxapine analogs and methods of use thereof
    Patent number: 7592333
    Abstract: The invention relates to novel compounds and methods of using them for modulating sleep.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: September 22, 2009
    Assignee: Hypnion, Inc.
    Inventors: Dale M. Edgar, David G. Hangauer, Kazumi Shiosaki, Michael Solomon, James F. White
  • LOXAPINE ANALOGS AND METHODS OF USE THEREOF
    Publication number: 20090186872
    Abstract: The invention relates to novel compounds and methods of using them for modulating sleep.
    Type: Application
    Filed: March 25, 2009
    Publication date: July 23, 2009
    Inventors: Dale M. Edgar, David G. Hangauer, Kazumi Shiosaki, Michael Solomon, James F. White
  • BENZISOXAZOLE PIPERAZINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20090163514
    Abstract: The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.
    Type: Application
    Filed: February 11, 2009
    Publication date: June 25, 2009
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar
  • Compositions and methods for modulating a kinase cascade
    Publication number: 20090149510
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
    Type: Application
    Filed: July 7, 2008
    Publication date: June 11, 2009
    Inventor: David G. Hangauer, JR.
  • Methods of treating sleep disorders
    Patent number: 7524864
    Abstract: The invention relates to novel antihistamines and methods of modulating sleep by administering a doxepin analog or a pharmaceutically effective salt thereof.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: April 28, 2009
    Assignee: Hypnion, Inc.
    Inventors: Dale M. Edgar, David G. Hangauer, James F. White
  • Benzisoxazole piperazine compounds and methods of use thereof
    Patent number: 7494998
    Abstract: The invention includes benzisoxazole piperazine compositions and methods of using them for modulating sleep.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: February 24, 2009
    Assignee: Hypnion, Inc.
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar
  • Doxepin analogs and methods of use thereof
    Patent number: 7482460
    Abstract: The invention relates to novel doxepin analog compounds and methods of modulating sleep by administering such compounds, or a pharmaceutically effective salt thereof.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: January 27, 2009
    Assignee: Hypnion, Inc.
    Inventors: Dale M. Edgar, David G. Hangauer, James F. White, Michael Solomon
  • Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
    Publication number: 20080287436
    Abstract: The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
    Type: Application
    Filed: May 19, 2008
    Publication date: November 20, 2008
    Inventors: David G. Hangauer, JR., Daniel Coughlin, Jeremy A. Cody, Jonathan Gale
  • Protection against and treatment of hearing loss
    Patent number: 7427608
    Abstract: The present invention provides a method for protecting against or treating hearing loss in a subject. This method involves administering an effective amount of a protein tyrosine kinase inhibitor to the subject to protect against or to treat hearing loss.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: September 23, 2008
    Assignees: The Research Foundation of State University of New York, Health Research, Inc.
    Inventors: Thomas Nicotera, Donald Henderson, David G. Hangauer, Jr.
  • Composition and methods for modulating a kinase cascade
    Publication number: 20080221102
    Abstract: The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
    Type: Application
    Filed: December 28, 2007
    Publication date: September 11, 2008
    Inventors: David G. Hangauer, Daniel Coughlin, Jeremy A. Cody, Jonathan Gale
  • Benzisoxazole Piperidine Compounds and Methods of Use Thereof
    Publication number: 20080214539
    Abstract: The invention includes benzisoxazole piperidine compositions and methods of using them for modulating sleep.
    Type: Application
    Filed: April 26, 2006
    Publication date: September 4, 2008
    Inventors: Daniel Coughlin, James F. White, Kazumi Shiosaki, David G. Hangauer, Michael Solomon, Dale M. Edgar