Patents by Inventor David G. Winkler

David G. Winkler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sclerostin binding antibody
    Patent number: 8637643
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: January 28, 2014
    Assignee: UCB Pharma, S.A.
    Inventors: John Latham, David G. Winkler
  • TREATMENT OF LUPUS, FIBROTIC CONDITIONS, AND INFLAMMATORY MYOPATHIES AND OTHER DISORDERS USING PI3 KINASE INHIBITORS
    Publication number: 20130344061
    Abstract: Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating lupus, a fibrotic condition, or inflammatory myopathies and other conditions (e.g., skin conditions).
    Type: Application
    Filed: March 15, 2013
    Publication date: December 26, 2013
    Applicant: INFINITY PHARMACEUTICALS, INC.
    Inventors: Vito J. PALOMBELLA, David G. WINKLER
  • Antibodies specific for sclerostin and methods for increasing bone mineralization
    Patent number: 8563271
    Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: October 22, 2013
    Assignee: UCB Manufacturing, Inc.
    Inventors: David G. Winkler, Jiye Shi, John Latham
  • ANTIBODIES AND DIAGNOSTICS
    Publication number: 20130267689
    Abstract: Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.
    Type: Application
    Filed: March 22, 2013
    Publication date: October 10, 2013
    Inventors: John Latham, David G. Winkler
  • Binding Agents
    Publication number: 20130203965
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Application
    Filed: January 15, 2013
    Publication date: August 8, 2013
    Inventors: John Latham, David G. Winkler
  • ANTIBODIES SPECIFIC FOR SCLEROSTIN AND METHODS FOR INCREASING BONE MINERALIZATION
    Publication number: 20120321636
    Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Application
    Filed: August 22, 2012
    Publication date: December 20, 2012
    Applicant: UCB Manufacturing, Inc.
    Inventors: David G. Winkler, Jiye Shi, John Latham
  • EPITOPES
    Publication number: 20110305702
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Application
    Filed: April 28, 2011
    Publication date: December 15, 2011
    Applicants: AMGEN INC., UCB PHARMA S.A.
    Inventors: HSIENG S. LU, CHRISTOPHER J. PASZTY, MARTYN KIM ROBINSON, ALISTAIR J. HENRY, KELLY SUE WARMINGTON, JOHN LATHAM, ALASTAIR LAWSON, DAVID G. WINKLER, AARON GEORGE WINTERS
  • ANTIBODIES SPECIFIC FOR SCLEROSTIN AND METHODS FOR INCREASING BONE MINERALIZATION
    Publication number: 20110206677
    Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Application
    Filed: May 5, 2011
    Publication date: August 25, 2011
    Applicant: UCB Manufacturing, Inc.
    Inventors: David G. Winkler, Jiye Shi, John Latham
  • Antibodies Specific for Sclerostin and Methods for Increasing Bone Mineralization
    Publication number: 20110206678
    Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Application
    Filed: May 5, 2011
    Publication date: August 25, 2011
    Applicant: UCB Manufacturing, Inc.
    Inventors: David G. Winkler, Jiye Shi, John Latham
  • Antibodies Specific for Sclerostin and Methods for Increasing Bone Mineralization
    Publication number: 20110195453
    Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Application
    Filed: December 1, 2010
    Publication date: August 11, 2011
    Applicant: UCB Manufacturing, Inc.
    Inventors: David G. Winkler, Jiye Shi, John Latham
  • Compositions and methods for increasing bone mineralization
    Patent number: 7985834
    Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: July 26, 2011
    Assignee: Celltech R & D, Inc.
    Inventors: David G. Winkler, John Latham, Jiye Shi
  • Compositions and Methods for Increasing Bone Mineralization
    Publication number: 20110150866
    Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 23, 2011
    Applicant: Darwin Discovery Limited
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • BINDING AGENTS
    Publication number: 20110097342
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Application
    Filed: November 19, 2010
    Publication date: April 28, 2011
    Applicants: AMGEN INC., UCB PHARMA S.A.
    Inventors: Christopher J. Paszty, Martyn K. Robinson, Kevin Graham, Alistair J. Henry, Kelly S. Warmington, John Latham, Hsieng S. Lu, Alastair Lawson, Andy Popplewell, Wenyan Shen, David G. Winkler, Aaron G. Winters
  • Sclerostin-binding antibodies
    Patent number: 7872106
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: January 18, 2011
    Assignees: Amgen Inc., UCB Pharma S.A.
    Inventors: Christopher J. Paszty, Martyn K. Robinson, Kevin Graham, Alistair J. Henry, Kelly S. Warmington, John Latham, Hsieng S. Lu, Alastair Lawson, Andy Popplewell, Wenyan Shen, David G. Winkler, Aaron G. Winters
  • Immunogenic peptides derived from sclerostin
    Patent number: 7868134
    Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: January 11, 2011
    Assignee: UCB Manufacturing, Inc.
    Inventors: David G. Winkler, Jiye Shi, John Latham
  • Antibodies associated with alterations in bone density
    Patent number: 7758858
    Abstract: Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-? binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: July 20, 2010
    Assignee: Darwin Discovery Ltd.
    Inventors: Mary E Brunkow, David J Galas, Brian Kovacevich, John T Mulligan, Bryan W Paeper, Jeffrey Van Ness, David G Winkler
  • Compositions and Methods for Increasing Bone Mineralization
    Publication number: 20100151524
    Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Application
    Filed: July 16, 2009
    Publication date: June 17, 2010
    Applicant: CELLTECH R & D, INC.
    Inventors: David G. Winkler, Jiye Shi, John Latham
  • ANTIBODIES AND DIAGNOSTICS
    Publication number: 20100015665
    Abstract: Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.
    Type: Application
    Filed: November 9, 2007
    Publication date: January 21, 2010
    Applicant: UCB PHARMA S.A.
    Inventors: John Latham, David G. Winkler
  • BINDING AGENTS
    Publication number: 20090304713
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Application
    Filed: November 24, 2008
    Publication date: December 10, 2009
    Applicants: AMGEN INC., UCB PHARMA S.A.
    Inventors: Christoper Paszty, Martin Kim Robinson, Kevin Graham, Alistair James Henry, Kelly Sue Hoffmann, John Latham, Hsieng Sen Lu, Alastair Lawson, Andy Popplewell, Wenyan Shen, David G. Winkler, Aaron George Winters
  • Antibodies specific for sclerostin
    Patent number: 7578999
    Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: August 25, 2009
    Assignee: Celltech R & D, Inc.
    Inventors: David G. Winkler, Jiye Shi, John Latham