Patents by Inventor David G. Winkler

David G. Winkler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for increasing bone mineralization
    Patent number: 7572899
    Abstract: Nucleic acids relating to human TGF-? binding proteins are disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: August 11, 2009
    Assignee: UCB SA
    Inventors: Mary E Brunkow, David J Galas, Brian Kovacevich, John T Mulligan, Bryan Paeper, Jeffrey Van Ness, David G Winkler
  • ANTIBODIES SPECIFIC FOR SCLEROSTIN AND METHODS FOR INCREASING BONE MINERALIZATION
    Publication number: 20090117118
    Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Application
    Filed: April 24, 2008
    Publication date: May 7, 2009
    Applicant: CELLTECH R & D, INC.
    Inventors: David G. Winkler, Jiye Shi, John Latham
  • Compositions and Methods for Increasing Bone Mineralization
    Publication number: 20080234219
    Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 25, 2008
    Applicant: Darwin Discovery Limited
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Compositions and Methods for Increasing Bone Mineralization
    Publication number: 20080182788
    Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 31, 2008
    Applicant: Darwin Discovery Limited
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Antibodies specific for sclerostin and methods of screening and use therefor
    Patent number: 7381409
    Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: June 3, 2008
    Assignee: Celltech R&D, Inc.
    Inventors: David G. Winkler, Jiye Shi, John Latham
  • Ligands for TGF-beta binding proteins and uses thereof
    Patent number: 7226902
    Abstract: Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: June 5, 2007
    Assignee: Celltech R&D, Inc.
    Inventors: David G. Winkler, John Latham, John Skonier, Diana Shpektor, Trenton Hayes, James Geoghegan
  • Methods for modulating bone mineralization
    Patent number: 7192583
    Abstract: Antibodies to a novel family of TGF-? binding proteins are disclosed, for use in methods of altering bone density and bone mineralization, which methods are applicable to the treatment of diseases including osteopenia and osteoporosis.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: March 20, 2007
    Assignee: Darwin Discovery Ltd.
    Inventors: Mary E Brunkow, David J Galas, Brian Kovacevich, John T Mulligan, Bryan W Paeper, Jeffrey Van Ness, David G Winkler
  • Antibodies associated with alterations in bone density
    Patent number: 6803453
    Abstract: Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-&bgr; binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: October 12, 2004
    Assignee: Darwin Discovery Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Antibodies associated with alterations in bone density
    Publication number: 20040158045
    Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Application
    Filed: February 27, 2004
    Publication date: August 12, 2004
    Applicant: Darwin Discovery Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Compositions and methods for increasing bone mineralization
    Publication number: 20040058321
    Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Application
    Filed: March 7, 2002
    Publication date: March 25, 2004
    Applicant: Darwin Discovery Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan Paeper, Jeffrey Van Ness, David G. Winkler
  • Compositions and methods for increasing bone mineralization
    Publication number: 20040009535
    Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
    Type: Application
    Filed: June 16, 2003
    Publication date: January 15, 2004
    Applicant: Celltech R&D, Inc.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Compositions and methods for increasing bone mineralization
    Publication number: 20030166247
    Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Application
    Filed: March 6, 2003
    Publication date: September 4, 2003
    Applicant: Darwin Discovery Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Compositions and methods for increasing bone mineralization
    Patent number: 6495736
    Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: December 17, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Polypeptides associated with alterations in bone density
    Patent number: 6489445
    Abstract: Compositions and methods for increasing bone density using antibodies directed to a novel class or family human of TGF-&bgr; binding proteins are disclosed. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis. The disclosed compositions include polypeptides, and their encoding polynucleotides, which specifically bind to at least one human bone morphogenic protein (BMP) selected from BMP-5 and BMP-6.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: December 3, 2002
    Assignee: Celltech R&D, Inc.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Nucleic acids encoding a novel family of TGF-&bgr; binding proteins from humans
    Patent number: 6395511
    Abstract: A novel human protein has been isolated which is encoded by a nucleic acid molecule comprising the polynucleotide sequence provided in SEQ ID NO:1 or a polynucleotide sequence that is completely complementary thereto. This novel protein binds to at least two members of the family of TGF-beta proteins, which are the human bone morphogenic protein-5 and human bone morphogenic protein-6.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: May 28, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler