Abstract: The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network Activation State (NAS) or a Network Inhibition State (NIS) for the cells using a computational model of the cellular network. The response of the cells to treatment is then predicted based on the NAS or NIS value that has been computed. The invention also comprises predictive methods for cellular responsiveness in which computation of a NAS or NIS value for the cells (e.g., tumor cells) is combined with use of a statistical classification algorithm. Biomarkers for predicting responsiveness to treatment with a therapeutic agent that targets a component within the ErbB signaling pathway are also provided.

Abstract: Systems and methods for controlling pre-delivery of content to user devices, such as mobile devices, from remote content servers (e.g., content delivery nodes over a network) are described. In some embodiments, the systems and methods receive an indication that a content item at a remote content server is available for pre-delivery to a mobile device over a mobile network, determine the mobile device is associated with sufficient content delivery credit to pre-deliver at least a fraction of the content item to the mobile device, and cause the at least fraction of the content item to be pre-delivered to the mobile device based on the determination.

Abstract: Systems and methods for delivering fractions of content to user devices before the content is selected or requested (e.g., a pre-delivery of content) are described. In some embodiments, the systems and methods receive an indication that content is available for pre-delivery from a content server to a user device over a network, determine a fraction (e.g., size) of the content available for pre-delivery that satisfies one or more predicted content playback conditions, and causes the determined fraction of the content available for pre-delivery to be delivered to the user device.

Abstract: A brokering device that manages multimedia information includes an interface device having access to a network and a multimedia service provider. The interface device enables selection of multimedia information from the network, and provides the selected multimedia information to a plurality of locations without requiring the user to specify a protocol associated with the multimedia information.

Abstract: A brokering device that manages multimedia information includes an interface device having access to a network and a multimedia service provider. The interface device enables selection of multimedia information from the network, and provides the selected multimedia information to a plurality of locations without requiring the user to specify a protocol associated with the multimedia information.

Abstract: Systems and methods for managing and pacing data flows are described. In some embodiments, the systems and methods may select a data flow for management, the data flow being transmitted from a first network equipment to a second network equipment, determine, at a third network equipment, a delivery performance of the data flow being transmitted to the second network equipment, detect network congestion based on the determined delivery performance of the data flow being transmitted to the second network equipment, and pace, at the third network device and based on the detected network congestion, delivery of the data flow to the second network equipment by reducing a rate at which the data flow is delivered to the second network equipment.

Abstract: A baffle arrangement disposed within the exhaust flue of a fuel-burning water heater promotes heat transfer from exhausted combustion by-products to the water storage chamber. The baffle arrangement has an elongate planar base and plural exhaust-directing fins spaced along opposite sides of the base. Each fin is a planar body extending perpendicularly from the base at an acute upward angle from a longitudinal centerline to a respective side of the base. The fins deflect combustion by-products laterally outwardly within the flue to promote heat transfer. The fins are of selected configurations generally increasing in surface area upwardly along the planar base for selectively controlling pressure drop within the exhaust flue. Hanger tabs project outwardly from the upper end of the base to suspend the baffle arrangement within the flue. The planar base, hanger tabs and exhaust-directing fins are formed integrally from a unitary body of sheet metal.

Abstract: Sustainable average data throughput rates for data transfer between a sender and a receiver are determined for a network in a steady-state condition. Delivery performance for data transferred in non-steady-state conditions is disregarded in determining sustainable average data throughput rates. The rates may be used to adapt file delivery to network conditions.

Abstract: Systems and methods for downloading data by conditionally using idle network capacity are described. In some embodiments, the systems and methods downloads into a buffer a first portion of media content in accordance with a first content streaming mode that permits downloading of media content data even when there is no idle network capacity, and upon determining that the buffer has been filled to a threshold level, downloads into the buffer a second portion of the media content in accordance with a second content streaming mode that permits downloading of media content data, e.g., only when there is idle network capacity.

Abstract: A brokering device that manages multimedia information includes an interface device having access to a network and a multimedia service provider. The interface device enables selection of multimedia information from the network, and provides the selected multimedia information to a plurality of locations without requiring the user to specify a protocol associated with the multimedia information.

Abstract: Congestion information is determined based on a file segment transferred to one of user terminals. The congestion information is available to a server or controller communicatively linked with a plurality of user terminals. The congestion information is shared with other user terminals that share a bottleneck link.

Abstract: Aa brokering device manages multimedia information including an interface device having access to a network and a multimedia service provider. The interface device enables selection of multimedia information from the network and provides the selected multimedia information to a plurality of locations without requiring the user to specify a protocol associated with the multimedia information.

Abstract: Systems and methods for controlling pre-delivery of content to user devices, such as mobile devices, from remote content servers (e.g., content delivery nodes over a network) are described. In some embodiments, the systems and methods receive an indication that a content item at a remote content server is available for pre-delivery to a mobile device over a mobile network, determine the mobile device is associated with sufficient content delivery credit to pre-deliver at least a fraction of the content item to the mobile device, and cause the at least fraction of the content item to be pre-delivered to the mobile device based on the determination.

Abstract: Systems and methods for delivering fractions of content to user devices before the content is selected or requested (e.g., a pre-delivery of content) are described. In some embodiments, the systems and methods receive an indication that content is available for pre-delivery from a content server to a user device over a network, determine a fraction (e.g., size) of the content available for pre-delivery that satisfies one or more predicted content playback conditions, and causes the determined fraction of the content available for pre-delivery to be delivered to the user device.

Abstract: Systems and methods for delivering content to user devices before the content is selected or requested (e.g. a pre-delivery of content) within predetermined delivery windows and/or during suitable pre-delivery conditions are described. In some embodiments, the systems and methods receive an indication that content is available for pre-delivery from a content server to a user device over a network, select a delivery window that satisfies one or more pre-delivery policy conditions associated with pre-delivery of content to the user device, and cause the content to be delivered to the user device upon commencement of the selected delivery window.

Abstract: A method and apparatus for processing at least one information feed are disclosed. For example, the method receives at least one content via at least one automated feed. The method associates the at least one content to one or more geographical locations on a map, wherein the one or more geographical locations are determined from the at least one content. The method then presents an access to the at least one content to a user via the map.

Abstract: A method and apparatus for providing case restoration in a communication network are disclosed. For example, the method obtains one or more content sources from one or more information feeds, and extracts textual information from the one or more content sources obtained from the one or more information feeds. The method then creates or updates a capitalization model based on the textual information.

Abstract: Aa brokering device manages multimedia information including an interface device having access to a network and a multimedia service provider. The interface device enables selection of multimedia information from the network and provides the selected multimedia information to a plurality of locations without requiring the user to specify a protocol associated with the multimedia information.

Abstract: Systems and methods for delivering content to user devices before the content is selected or requested (e.g., a pre-delivery of content) are described. In some embodiments, the system and methods receive, from a content server, information associated with content items available for retrieval from the content server and associated with one or more applications resident on a user device, select a subset of content items from the content items available for retrieval to deliver to the user device based on content usage information associated with the user device, and cause the user device to retrieve at least a portion of the selected subset of content items from the content server.

Abstract: Systems and methods for delivering content to user devices before the content is selected or requested (e.g., a pre-delivery of content) are described. In some embodiments, the system and methods receive, from a content server, information associated with content items available for retrieval from the content server and associated with one or more applications resident on a user device, select a subset of content items from the content items available for retrieval to deliver to the user device based on content usage information associated with the user device, and cause the user device to retrieve at least a portion of the selected subset of content items from the content server.