Abstract: Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy.

Abstract: Disclosed herein is an apparatus of a radio communication device, where the apparatus may include a plurality of signal paths, each signal path of the plurality of signal paths is configured to receive a radio frequency, RF, signal from a corresponding RF circuit. The apparatus may also include a processor configured to determine first signal paths and a second signal path from the plurality of signal paths, wherein the first signal paths are configured to receive first RF signals of the RF signals. The processor may also be configured to demodulate the first RF signals received from the first signal paths to decode received communication data; perform, for a frequency band, an RF environmental sensing operation based on a digital signal converted from a second RF signal of the RF signals, wherein the second RF signal is provided by the second signal path.

Abstract: Proposed is a street address signage device, for commercial or residential use, wherein said street address signage device is configured to be affixed to a building, or another structure or an auxiliary edifice on a residence or property, for enhanced wayfinding purposes. The primary purpose of the device is to clearly and brilliantly display a street address during all lighting and weather conditions to passing traffic or anyone within the vicinity. The secondary purpose is to alert and/or advertise with excessive/aggressive means, to anyone within eyesight of said residence or property, a heightened-need beacon or distress symbol or specialized display. In a most preferred embodiment the heightened need is an emergency situation. In said most preferred embodiment said primary purpose comprises displaying numbers on a lighted front screen and said secondary purpose comprises flashing or strobing bright lights.

Abstract: A system includes a computer including a processor and a memory storing instructions executable by the processor to detect a position of a head of an occupant within a passenger compartment of a vehicle. The instructions include instructions to conduct a hearing test based on the position of the head of the occupant. The instructions include instructions to output sound at least at one of a specified frequency or amplitude, the specified frequency or amplitude selected based on results of the hearing test.

Abstract: Various implementations include a light including a central body and two or more lighting portions. The central body has a longitudinal axis, a first portion, and a second portion opposite and spaced apart along the longitudinal axis from the first portion. The two or more lighting portions each include two or more red-green-blue (RGB) light-emitting diodes (LEDs). The two or more LEDs of each of the two or more lighting portions are linearly spaced apart from each other such that each of the two or more lighting portions extend from the first portion to the second portion. The two or more lighting portions are circumferentially spaced apart from each other about the longitudinal axis.

Abstract: A device and method and graphical user interface for positioning a selection and selecting on a computing device with a touch-sensitive display: Displaying within content a selection having a selection start point and a selection end point; displaying a control icon; detecting a contact on the touch-sensitive display; and in response to detecting a change in a horizontal and vertical position of the contact beginning anywhere on the control icon: changing a horizontal position of the selection start point within the content by an amount proportional to the change in a horizontal position of the contact and changing a vertical position of the selection start point within the content by an amount proportional to the change in a vertical position of the contact; wherein the horizontal position of the selection start point with respect to the control icon is changed and a vertical position of the control icon is changed.

Abstract: The invention relates to novel processes using enzymes for the production of oligonucleotides, wherein said processes are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy.

Abstract: The present invention relates to a process for making an extract of Linum usitatissimum seeds. Furthermore, it relates to the extract itself and to a cosmetic composition comprising this extract. Furthermore, it relates to the use of this extract or of the cosmetic composition comprising this extract for hair styling or for conditioning or for protection against UV radiation.

Abstract: The present invention provides an apparatus and method for processing a beverage. The apparatus comprises: an input, an output, a sonication chamber defined in a flow path between the input and the output, a pump configured to move a suspension through the sonication chamber towards the output, and a sonotrode configured to sonicate the matter suspension as it passes through the sonication chamber. At any position in the sonication chamber, a wall of the sonication chamber is provided within less than 3 centimetres of the position.

Abstract: A wheat variety designated PMWH102204613, the plants and seeds of wheat variety PMWH102204613, methods for producing a wheat plant produced by crossing the variety PMWH102204613 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety PMWH102204613 with another wheat line or plant, and the creation of variants by backcrossing, mutagenesis or transformation of variety PMWH102204613 are disclosed. Methods for producing other wheat varieties or breeding lines derived from wheat variety PMWH102204613 and to wheat varieties or breeding lines produced by those methods are also provided.

Abstract: A wheat variety designated PMWH80242964, the plants and seeds of wheat variety PMWH80242964, methods for producing a wheat plant produced by crossing the variety PMWH80242964 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety PMWH80242964 with another wheat line or plant, and the creation of variants by backcrossing, mutagenesis or transformation of variety PMWH80242964 are disclosed. Methods for producing other wheat varieties or breeding lines derived from wheat variety PMWH80242964 and to wheat varieties or breeding lines produced by those methods are also provided.

Abstract: A wheat variety designated PMWH80246940, the plants and seeds of wheat variety PMWH80246940, methods for producing a wheat plant produced by crossing the variety PMWH80246940 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety PMWH80246940 with another wheat line or plant, and the creation of variants by backcrossing, mutagenesis or transformation of variety PMWH80246940 are disclosed. Methods for producing other wheat varieties or breeding lines derived from wheat variety PMWH80246940 and to wheat varieties or breeding lines produced by those methods are also provided.

Abstract: The present invention relates to compounds with the ability to stimulate/induce ubiquitination of a target protein/target proteins. The compounds of the present invention may stimulate/induce ubiquitination of a target protein/target proteins; i.e. via degradation of a target protein/target proteins by the cullin-RING ubiquitin ligase (CRL). Such target protein/target proteins may be proteins involved in diseases, like cancer, metabolic disorder, infectious disease and/or neurological disorder. The invention also relates to the compounds and composition for use as medicaments as well as pharmaceutical compositions comprising these compounds. Particularly, the compounds of the present invention may degrade proteins associated with cancer, metabolic disorder, infectious disease and/or neurological disorder.

Abstract: Embodiments of the disclosure concern systems, methods, and/or compositions for cultivation of mammalian viruses, including at least human noroviruses and sapoviruses within the Caliciviridae family of viruses. The ex vivo culture systems include intestinal enteroids in combination with bile or a functionally active fraction or component thereof. In specific embodiments, the culture system is utilized to test inactivation compounds for therapeutic or environmental efficacy and to test contaminated comestibles and/or environmental entities for determination of the presence of infectious virus. Furthermore, antiviral compositions may be tested using systems of the disclosure, including drugs, small molecule inhibitors, and biologics such as neutralizing monoclonal antibodies.

Abstract: A mobile computing device with a touch-sensitive display wherein: a pointer is displayed; a control icon is displayed; a contact on the touch-sensitive display is detected; in response to detecting a change in a horizontal position of the contact beginning anywhere on the control icon, a horizontal position of the pointer is changed; and in response to detecting a change in a vertical position of a contact beginning anywhere on the control icon: a vertical position of the pointer is changed; and a vertical position of the control icon is changed; and wherein a position of the pointer with respect to the control icon is changed.

Abstract: Detecting a selection of one or more files in a list of files; in response to detecting a selection of two one or more files selected from a group consisting of doc files and doc set files, displaying in a list of tab icons adjacent to a display-area a tab icon linked to each selected file; saving in a list of files a new doc set file comprising links to each selected file; and in response to detecting a selection of the new doc set file in the list of files, displaying in a list of tab icons adjacent to a display-area a tab icon linked to each file in the new doc set file; wherein a doc file is selected from a group consisting of a word processor file, a spreadsheet file, a presentation file, an image file, a drawing file, a PDF file, and a text file.

Abstract: An orthopaedic device for securing between first and second regions of bone separated by a growth plate, the orthopaedic device comprising: a first portion to secure to a first fixing location on the first bone region; a second portion to secure to a second fixing location on the second bone region, the first fixing location and the second fixing location being laterally offset relative to a longitudinal axis of the bone; wherein the first and second portions are pivotally coupled between a first coupling location on the first portion and a second coupling location on the second portion such that movement of the first and second portions away from each other in a direction parallel to the longitudinal axis of the bone causes relative rotation of the first bone region and the second bone region thereby reducing the lateral offset of the first location and the second location.

Abstract: The disclosure herein relates to systems, methods, and devices for estimating a total estimated power consumption of a wireless modem. The power estimation may include determining a static power consumption estimate based on configuration parameters of modem subcomponents of a wireless modem. The power estimation may also include determining a dynamic power consumption estimate based on a sum of, for each corresponding active power amplifier of the wireless modem, a predefined power offset associated with a current reported power level for the corresponding active power amplifier and a maximum transmit power of a predefined range associated with the current reported power level of the active power amplifier. The power estimation may also include combining the static power consumption estimate and the dynamic power consumption estimate as the total estimated power consumption of the wireless modem.

Abstract: A device includes a camera sensor and an illumination source structure. The illumination source structure is positioned to emit light towards a field of view of the camera sensor. The illumination source structure includes a bore, internal threads extending along at least a portion of a length of the bore, and a light emitting diode (LED) positioned within the bore such that the internal threads encircle a lens of the LED.

Abstract: A system for dynamically controlling an echo canceler includes a processor programmed to receive audio data from an audio sensor, to determine a present type of noise in the received audio data, based on the present type of noise, to determine a number of taps to be removed from an echo canceler, and to execute the echo canceler with a reduced number of taps based on the number of taps to be removed.