Abstract: The present invention relates to compounds with the ability to stimulate/induce ubiquitination of a target protein/target proteins. The compounds of the present invention may stimulate/induce ubiquitination of a target protein/target proteins; i.e. via degradation of a target protein/target proteins by the cullin-RING ubiquitin ligase (CRL). Such target protein/target proteins may be proteins involved in diseases, like cancer, metabolic disorder, infectious disease and/or neurological disorder. The invention also relates to the compounds and composition for use as medicaments as well as pharmaceutical compositions comprising these compounds. Particularly, the compounds of the present invention may degrade proteins associated with cancer, metabolic disorder, infectious disease and/or neurological disorder.

Abstract: The invention generally relates to systems and methods for increasing reaction yield. In certain embodiments, the invention provides systems for increasing a yield of a chemical reaction that include a pneumatic sprayer configured to generate a liquid spray discharge from a solvent. The solvent includes a plurality of molecules, a portion of which react with each other within the liquid spray discharge to form a reaction product. The system also includes a collector positioned to receive the liquid spray discharge including the unreacted molecules and the reaction product. The system also includes a recirculation loop connected from the collector to the pneumatic sprayer in order to allow the unreacted molecules and the reaction product to be recycled through the pneumatic sprayer, thereby allowing a plurality of the unreacted molecules to react with each other as the unreacted molecules cycle again through the system.

Abstract: An audio session management method may involve: determining, by an audio session manager, one or more first media engine capabilities of a first media engine of a first smart audio device, the first media engine being configured for managing one or more audio media streams received by the first smart audio device and for performing first smart audio device signal processing for the one or more audio media streams according to a first media engine sample clock; receiving, by the audio session manager and via a first application communication link, first application control signals from the first application; and controlling the first smart audio device according to the first media engine capabilities, by the audio session manager, via first audio session management control signals transmitted to the first smart audio device via a first smart audio device communication link and without reference to the first media engine sample clock.

Abstract: An additive manufacturing machine may include a beam source, a process chamber, a beam column operably coupled to the process chamber and/or defining a portion of the process chamber, and a gaseous ionization detector disposed about the beam column. The gaseous ionization detector may be configured to detect elementary particles corresponding to an ionizing gas ionized by an energy beam from the beam source. A method of additively manufacturing a three-dimensional object may include determining data from a gaseous ionization detector disposed about a beam column of an additive manufacturing machine, and additively manufacturing a three-dimensional object using the additive manufacturing machine based at least in part on the data from the gaseous ionization detector.

Abstract: This disclosure describes an apparatus and method of an embodiment of an invention that is a ceiling tile microphone that includes: a plurality of microphones positioned at predetermined locations and coupled together as a microphone array used for beamforming; a single ceiling tile with an outer surface on the front side of the ceiling tile where the outer surface is acoustically transparent, the microphone array couples to the back side of the single ceiling tile, the microphone array combines with the ceiling tile as a single unit, the single unit is mountable in a drop ceiling in place of a single ceiling tile included in the drop ceiling, all or part of the single unit is in the drop space of the drop ceiling when the single unit is used in a drop ceiling mounting configuration; where the ceiling tile microphone further includes beamforming, acoustic echo cancellation, and auto mixing.

Abstract: A system and method for displaying images of internal anatomy includes an image processing device configured to provide high resolution images of the surgical field from low resolution scans during the procedure. The image processing device digitally manipulates a previously-obtained high resolution baseline image to produce many representative images based on permutations of movement of the baseline image. During the procedure a representative image is selected having an acceptable degree of correlation to the new low resolution image. The selected representative image and the new image are merged to provide a higher resolution image of the surgical field. The image processing device is also configured to provide interactive movement of the displayed image based on movement of the imaging device, and to permit placement of annotations on the displayed image to facilitate communication between the radiology technician and the surgeon.

Abstract: A tire pre-conditioning system includes a first mandrel, a second mandrel spaced apart from the first mandrel, and a controller in communication with the first mandrel and the second mandrel. The first mandrel is fixedly attached to a first shaft and including a first tapered sidewall. The second mandrel is fixedly attached to a second shaft and including a second tapered sidewall. The controller is operable to axially move the first mandrel and the second mandrel toward one another until the first and second tapered sidewalls are opposing respective beads of a tire, and supply pressurized fluid into an internal cavity of the tire to inflate the tire. The inflating causing the beads to move relative to mandrels while contacting the opposing respective tapered sidewalls to burnish the beads of the tire.

Abstract: A virtual image generation system comprises a planar optical waveguide having opposing first and second faces, an in-coupling (IC) element configured for optically coupling a collimated light beam from an image projection assembly into the planar optical waveguide as an in-coupled light beam, a first orthogonal pupil expansion (OPE) element associated with the first face of the planar optical waveguide for splitting the in-coupled light beam into a first set of orthogonal light beamlets, a second orthogonal pupil expansion (OPE) element associated with the second face of the planar optical waveguide for splitting the in-coupled light beam into a second set of orthogonal light beamlets, and an exit pupil expansion (EPE) element associated with the planar optical waveguide for splitting the first and second sets of orthogonal light beamlets into an array of out-coupled light beamlets that exit the planar optical waveguide.

Abstract: A Data Security Management System using a communications interface configured to receive and transmit one or more portions of Post Quantum Resistant Encrypted data within a network comprising a plurality of endpoints. Using End-to-End (E2E) Post Quantum Resistant encryption techniques to protect the data, the Data Security Management System provides the flexibility for multiple data schemes in a distributive environment such as, but not limited to, Hyperledger. The system uses a Policy Manager to perform the base configuration of the session to be transmitted or received in an encrypted state. This encrypted state comprises Post Quantum Cryptographic algorithm in use for that session, inclusive with associated keys or digital signatures. The Policy Manager is further configured to verify an identity of endpoint by a multifactor cryptographic authentication mechanism or a biometric authentication mechanism to validate a connection to or from an endpoint.

Abstract: Embodiments of the disclosure concern systems, methods, and/or compositions for cultivation of mammalian viruses, including at least human noroviruses and sapoviruses within the Caliciviridae family of viruses. The ex vivo culture systems include intestinal enteroids in combination with bile or a functionally active fraction or component thereof. In specific embodiments, the culture system is utilized to test inactivation compounds for therapeutic or environmental efficacy and to test contaminated comestibles and/or environmental entities for determination of the presence of infectious virus. Furthermore, antiviral compositions may be tested using systems of the disclosure, including drugs, small molecule inhibitors, and biologics such as neutralizing monoclonal antibodies.

Abstract: A mobile computing device with a touch-sensitive display wherein: a pointer is displayed; a control icon is displayed; a contact on the touch-sensitive display is detected; in response to detecting a change in a horizontal position of the contact beginning anywhere on the control icon, a horizontal position of the pointer is changed; and in response to detecting a change in a vertical position of a contact beginning anywhere on the control icon: a vertical position of the pointer is changed; and a vertical position of the control icon is changed; and wherein a position of the pointer with respect to the control icon is changed.

Abstract: Detecting a selection of one or more files in a list of files; in response to detecting a selection of two one or more files selected from a group consisting of doc files and doc set files, displaying in a list of tab icons adjacent to a display-area a tab icon linked to each selected file; saving in a list of files a new doc set file comprising links to each selected file; and in response to detecting a selection of the new doc set file in the list of files, displaying in a list of tab icons adjacent to a display-area a tab icon linked to each file in the new doc set file; wherein a doc file is selected from a group consisting of a word processor file, a spreadsheet file, a presentation file, an image file, a drawing file, a PDF file, and a text file.

Abstract: An orthopaedic device for securing between first and second regions of bone separated by a growth plate, the orthopaedic device comprising: a first portion to secure to a first fixing location on the first bone region; a second portion to secure to a second fixing location on the second bone region, the first fixing location and the second fixing location being laterally offset relative to a longitudinal axis of the bone; wherein the first and second portions are pivotally coupled between a first coupling location on the first portion and a second coupling location on the second portion such that movement of the first and second portions away from each other in a direction parallel to the longitudinal axis of the bone causes relative rotation of the first bone region and the second bone region thereby reducing the lateral offset of the first location and the second location.

Abstract: The disclosure herein relates to systems, methods, and devices for estimating a total estimated power consumption of a wireless modem. The power estimation may include determining a static power consumption estimate based on configuration parameters of modem subcomponents of a wireless modem. The power estimation may also include determining a dynamic power consumption estimate based on a sum of, for each corresponding active power amplifier of the wireless modem, a predefined power offset associated with a current reported power level for the corresponding active power amplifier and a maximum transmit power of a predefined range associated with the current reported power level of the active power amplifier. The power estimation may also include combining the static power consumption estimate and the dynamic power consumption estimate as the total estimated power consumption of the wireless modem.

Abstract: A device includes a camera sensor and an illumination source structure. The illumination source structure is positioned to emit light towards a field of view of the camera sensor. The illumination source structure includes a bore, internal threads extending along at least a portion of a length of the bore, and a light emitting diode (LED) positioned within the bore such that the internal threads encircle a lens of the LED.

Abstract: A system for dynamically controlling an echo canceler includes a processor programmed to receive audio data from an audio sensor, to determine a present type of noise in the received audio data, based on the present type of noise, to determine a number of taps to be removed from an echo canceler, and to execute the echo canceler with a reduced number of taps based on the number of taps to be removed.

Abstract: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

Abstract: Described herein are methods and compositions for use in improving a vascular barrier of endothelial cells. The methods may include the use of barrier agonist compounds and improved techniques for culturing endothelial cells. The improved methods and compositions for culturing endothelial cells may include at least one or more of the following: an adenylyl cyclase activator; an activator of Sphingosine-1-phosphate (S1P) receptor internalization; a direct or indirect inducer of tight junction protein expression, and a direct or indirect inducer of adherens junction protein expression.

Abstract: A system for dynamically controlling an echo canceler includes a processor programmed to receive audio data from an audio sensor, to determine a present type of noise in the received audio data, based on the present type of noise, to determine a number of taps to be removed from an echo canceler, and to execute the echo canceler with a reduced number of taps based on the number of taps to be removed.

Abstract: Embodiments of the disclosure concern systems, methods, and/or compositions for cultivation of mammalian viruses, including at least human noroviruses and sapoviruses within the Caliciviridae family of viruses. The ex vivo culture systems include intestinal enteroids in combination with bile or a functionally active fraction or component thereof. In specific embodiments, the culture system is utilized to test inactivation compounds for therapeutic or environmental efficacy and to test contaminated comestibles and/or environmental entities for determination of the presence of infectious virus. Furthermore, antiviral compositions may be tested using systems of the disclosure, including drugs, small molecule inhibitors, and biologics such as neutralizing monoclonal antibodies.