Patents by Inventor David H. Coy

David H. Coy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel dodecapeptides, intermediates therefor, and compositions and methods employing said dodecapeptides
    Patent number: 4127524
    Abstract: Novel dodecapeptides having the following amino acid sequence:H-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel hexacosapeptides, intermediates therefore and pharmaceutical compositions and methods employing said hexacosapeptides
    Patent number: 4127539
    Abstract: Novel hexacosapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ala-Ile-Ile-Lys-Asn-Ala-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histadine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel octapeptides, intermediates therefor, and compositions and methods employing said octapeptides
    Patent number: 4127533
    Abstract: Novel octapeptides having the following amino acid sequence:H-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; the pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel derivatives of gamma-endorphins, intermediates therefor, and compositions and methods employing said derivatives
    Patent number: 4127518
    Abstract: Novel .gamma.-endorphins represented by the formula 1H-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel derivatives of .delta.-endorphins, intermediates therefor, and compositions and methods employing said derivatives
    Patent number: 4127540
    Abstract: Novel .delta.-endorphins represented by the formula:H-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Y I.wherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel triacontapeptides, intermediates therefor and pharmaceutical compositions and methods employing said triacontapeptides
    Patent number: 4127522
    Abstract: Novel triacontapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline, D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel decapeptides, intermediates therefor, and compositions and methods employing said decapeptides
    Patent number: 4127541
    Abstract: Novel decapeptides having the following amino acid sequence:H-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel derivatives of alpha-endorphin, intermediates therefor and compositions and methods employing said derivatives
    Patent number: 4127528
    Abstract: Novel hexadecapeptides represented by formula Ih-tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Ywherein X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-aspartic acid, D-asparagine, D-aroline, D-histidine, D-lysine and D-arginine; Y is selected from the group consisting of hydroxy, amino, loweralkylamino, dialkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel tetracosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said tetracosapeptides
    Patent number: 4127537
    Abstract: Novel tetracosapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ala-Ile-Ile-Lys-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel tripeptides, intermediates therefor and pharmaceutical compositions and methods employing said tripeptides
    Patent number: 4127534
    Abstract: Novel tripeptides having the following amino acid sequenceH-Tyr-X-Gly-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel undecapeptides, intermediates therefor, and compositions and methods employing said undecapeptides
    Patent number: 4127523
    Abstract: Novel undecapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and the pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel octacosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said octacosapeptides
    Patent number: 4127521
    Abstract: Novel octacosapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel pentacosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said pentacosapeptides
    Patent number: 4127538
    Abstract: Novel pentacosapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ala-Ile-Ile-Lys-Asn-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel docosapeptides, intermediates therefore and pharmaceutical compositions and methods employing said docosapeptides
    Patent number: 4127517
    Abstract: Novel docosapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ala-Ilewherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel eicosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said eicosapeptides
    Patent number: 4127529
    Abstract: Novel eicosapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Octadecapeptides, intermediates therefor, and compositions and methods employing said octadecapeptides
    Patent number: 4127519
    Abstract: Novel octadecapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel tricosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said tricosapeptides
    Patent number: 4127536
    Abstract: Novel tricosapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ala-Ile-Ile-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel heptapeptides, intermediates therefor, and compositions and methods employing said heptapeptides
    Patent number: 4127532
    Abstract: Novel heptapeptides having the following amino acid sequence:H-Tyr-X-Gly-Phe-Met-Thr-Ser-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine or D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino, and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • Novel heneicosapeptides, intermediates therefor and pharmaceutical compositions and methods employing said heneicosapeptides
    Patent number: 4127530
    Abstract: Novel heneicosapeptides having the following amino acid sequenceH-Tyr-X-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys -Asn-Ala-Ywherein: X is a chiral residue of a D-amino acid selected from the group consisting of D-alanine, D-leucine, D-isoleucine, D-valine, D-phenylalanine, D-tyrosine, D-tryptophan, D-serine, D-threonine, D-methionine, D-glutamic acid, D-glutamine, D-proline D-aspartic acid, D-asparagine, D-lysine, D-arginine and D-histidine; and Y is selected from the group consisting of hydroxy, amino, loweralkylamino, diloweralkylamino and lower alkoxy; and the pharmaceutically acceptable salts thereof; intermediates useful in making the novel compounds; and pharmaceutical compositions and methods employing the novel compounds.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: November 28, 1978
    Inventors: David H. Coy, Abba J. Kastin
  • (Pyro)-Glu-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHR and intermediates
    Patent number: 4024121
    Abstract: [D-Ser.sup.4,D-Leu.sup.6,desGly-NH.sub.2.sup.10 ]-LH-RH (lower alkyl)amides, salts thereof, and intermediates used for the synthesis thereof are disclosed. The compounds have potent LH- and FSH-releasing hormone properties.
    Type: Grant
    Filed: January 27, 1976
    Date of Patent: May 17, 1977
    Inventors: Andrew V. Schally, David H. Coy