Patents by Inventor David H. Fine

David H. Fine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210100972
    Abstract: A device and method for treating high-altitude sickness can include a handheld device, and can deliver a therapeutic amount of nitric oxide to an individual's lungs in order to minimize or treat high-altitude sickness. The device is self-contained and portable, which allows an individual to carry and use the device in high-altitude or other low-oxygen environments.
    Type: Application
    Filed: September 18, 2020
    Publication date: April 8, 2021
    Applicant: VERO Biotech LLC
    Inventors: David H. FINE, Gregory VASQUEZ, Bryan JOHNSON
  • Patent number: 10960168
    Abstract: A method and device can alternately deliver high concentration of nitric oxide and oxygen-enriched air. A method of providing a therapeutic amount of nitric oxide to a mammal can include delivering one or more breaths of a therapeutic amount of nitric oxide to the mammal and delivering one or more breaths of an amount of oxygen-enriched air to the mammal immediately after the one or more breaths of the therapeutic amount of nitric oxide.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: March 30, 2021
    Assignee: VERO Biotech LLC
    Inventors: David H. Fine, Lee Leichter
  • Patent number: 10926054
    Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: February 23, 2021
    Assignee: Vero Biotech LLC
    Inventors: David H. Fine, Bryan Johnson, Gregory Vasquez
  • Publication number: 20200368271
    Abstract: A method of modulating oxygen saturation levels can include measuring oxygen saturation levels in a patient, administering inhaled nitric oxide, adjusting the dose of oxygen in real time to a second dose based on the inhaled nitric oxide.
    Type: Application
    Filed: January 27, 2020
    Publication date: November 26, 2020
    Inventors: Kurt A. DASSE, Priscilla C. PETIT, David H. FINE, Mark K. WEDEL
  • Patent number: 10814092
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: October 27, 2020
    Assignee: VERO Biotech LLC
    Inventors: David P. Rounbehler, David H. Fine
  • Publication number: 20200282375
    Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
    Type: Application
    Filed: October 1, 2019
    Publication date: September 10, 2020
    Inventors: David H. FINE, David P. ROUNBEHLER, Gregory VASQUEZ, Bryan JOHNSON
  • Publication number: 20200180958
    Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
    Type: Application
    Filed: July 15, 2019
    Publication date: June 11, 2020
    Applicant: VERO Biotech LLC
    Inventors: David H. FINE, Gregory VASQUEZ, David P. ROUNBEHLER
  • Publication number: 20200139073
    Abstract: Various systems generating nitric oxide are disclosed herein. According to one embodiment, the system includes a first gas source providing nitrogen dioxide mixed in air or oxygen, and a second gas source supplying compressed air and/or compressed oxygen. The system also includes a ventilator coupled to the first and second gas sources, wherein the ventilator is resistant to nitrogen dioxide. The ventilator regulates gas flow and allows for the adjustment of nitrogen dioxide concentration in the gas flow. The system further includes one or more conversion devices operably coupled to the ventilator where the conversion devices convert nitrogen dioxide into nitric oxide. A patient interface delivers nitric oxide to the patient and is operably coupled to the conversion devices. The system allows oxygen and nitric oxide levels to be varied independently.
    Type: Application
    Filed: June 20, 2019
    Publication date: May 7, 2020
    Applicant: VERO Biotech LLC
    Inventors: Alfred TECTOR, Priscilla C. PETIT, Kurt A. DASSE, David H. FINE
  • Publication number: 20200139071
    Abstract: Various systems generating nitric oxide are disclosed herein. According to one embodiment, the system includes a first gas source providing nitrogen dioxide mixed in air or oxygen, and a second gas source supplying compressed air and/or compressed oxygen. The system also includes a ventilator coupled to the first and second gas sources, wherein the ventilator is resistant to nitrogen dioxide. The ventilator regulates gas flow and allows for the adjustment of nitrogen dioxide concentration in the gas flow. The system further includes one or more conversion devices operably coupled to the ventilator where the conversion devices convert nitrogen dioxide into nitric oxide. A patient interface delivers nitric oxide to the patient and is operably coupled to the conversion devices. The system allows oxygen and nitric oxide levels to be varied independently.
    Type: Application
    Filed: June 18, 2019
    Publication date: May 7, 2020
    Applicant: VERO Biotech LLC
    Inventors: David H. FINE, Bryan JOHNSON, Gregory VASQUEZ
  • Publication number: 20190217043
    Abstract: A system for delivering a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent.
    Type: Application
    Filed: January 14, 2019
    Publication date: July 18, 2019
    Applicant: VERO BIOTECH LLC
    Inventors: David H. FINE, Gregory VASQUEZ, Bryan Johnson, Ryan Denton, Lucas G. Gamero
  • Publication number: 20190209993
    Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
    Type: Application
    Filed: October 1, 2018
    Publication date: July 11, 2019
    Applicant: VERO BIOTECH LLC
    Inventors: David H. Fine, David R. Rounbehler, Gregory Vasquez, Bryan Johnson
  • Publication number: 20190143068
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.
    Type: Application
    Filed: November 12, 2018
    Publication date: May 16, 2019
    Applicant: VERO BIOTECH LLC
    Inventors: David P. Rounbehler, David H. Fine
  • Publication number: 20190092639
    Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
    Type: Application
    Filed: September 24, 2018
    Publication date: March 28, 2019
    Applicant: VERO BIOTECH LLC
    Inventors: David H. Fine, Gregory Vasquez, David P. Rounbehler
  • Patent number: 10179222
    Abstract: A system for delivering a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent. In certain embodiments, the reservoir includes a restrictor.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: January 15, 2019
    Assignee: VERO BIOTECH LLC
    Inventors: David H. Fine, Gregory Vasquez, Bryan Johnson, Ryan Denton, Lucas G. Gamero
  • Patent number: 10124142
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: November 13, 2018
    Assignee: VERO BIOTECH LLC
    Inventors: David P. Rounbehler, David H. Fine
  • Publication number: 20180311460
    Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
    Type: Application
    Filed: April 30, 2018
    Publication date: November 1, 2018
    Applicant: GENO LLC
    Inventors: David R. Rounbehler, David H. Fine
  • Patent number: 10113983
    Abstract: Disclosed are a highly selective, highly sensitive method and apparatus for detecting vapors from explosives at low concentrations such as 1 part in 1014. Airborne explosives vapors are selectively adsorbed on a spiral-wound platinum or platinum-coated ribbon of a preconcentrator cartridge while trapping of nitrogen oxides is avoided. The vapors are released and partially decomposed to liberate nitric oxide gas by flash-heating of the ribbon, these products may then be pyrolyzed if necessary to complete the liberation of nitric oxide gas, and then the liberated nitric oxide gas is detected, as by chemiluminescent detection. Also described are various systems incorporating the explosives vapor detector such as a walk-through portal, a vehicle sniffer, and a system incorporated into the air-handling apparatus of a building.
    Type: Grant
    Filed: May 9, 1985
    Date of Patent: October 30, 2018
    Assignee: THERMO FISHER SCIENTIFIC INC.
    Inventors: David H. Fine, Freeman W. Fraim, James E. Buckley
  • Patent number: 10086352
    Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: October 2, 2018
    Assignee: VERO BIOTECH LLC
    Inventors: David H. Fine, David R. Rounbehler, Gregory Vasquez, Brian Johnson
  • Patent number: 10081544
    Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: September 25, 2018
    Assignee: VERO BIOTECH LLC
    Inventors: David H. Fine, Gregory Vasquez, David P. Rounbehler
  • Patent number: 9956373
    Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
    Type: Grant
    Filed: September 1, 2014
    Date of Patent: May 1, 2018
    Assignee: GENO LLC
    Inventors: David P. Rounbehler, David H. Fine