Patents by Inventor David H. Persing

David H. Persing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERMOSTABLE POLYMERASE INHIBITOR COMPOSITIONS AND METHODS
    Publication number: 20220389427
    Abstract: The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.
    Type: Application
    Filed: March 4, 2022
    Publication date: December 8, 2022
    Applicant: Cepheid
    Inventors: Sergey G. Lokhov, Alexander A. Gall, Vera Baraznenok, Ekaterina V. Viazovkina, Irina Shishkina, David H. Persing
  • Thermostable polymerase inhibitor compositions and methods
    Patent number: 11299739
    Abstract: The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: April 12, 2022
    Assignee: CEPHEID
    Inventors: Sergey G. Lokhov, Alexander A. Gall, Vera Baraznenok, Ekaterina V. Viazovkina, Irina Shishkina, David H. Persing
  • METHODS AND APPARATUS FOR SEQUENTIAL AMPLIFICATION REACTIONS
    Publication number: 20210285025
    Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
    Type: Application
    Filed: December 22, 2020
    Publication date: September 16, 2021
    Inventors: Joseph H. Smith, David H. Persing, Alan Wortman, Ronald Chang, David Swenson
  • Methods and apparatus for sequential amplification reactions
    Patent number: 10907202
    Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: February 2, 2021
    Assignee: Cepheid
    Inventors: Joseph H. Smith, David H. Persing, Alan Wortman, Ronald Chang, David Swenson
  • THERMOSTABLE POLYMERASE INHIBITOR COMPOSITIONS AND METHODS
    Publication number: 20190316132
    Abstract: The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.
    Type: Application
    Filed: June 6, 2017
    Publication date: October 17, 2019
    Inventors: Sergey G. Lokhov, Alexander A. Gall, Vera Baraznenok, Ekaterina V. Viazovkina, Irina Shishkina, David H. Persing
  • METHODS AND APPARATUS FOR SEQUENTIAL AMPLIFICATION REACTIONS
    Publication number: 20180187243
    Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
    Type: Application
    Filed: December 20, 2017
    Publication date: July 5, 2018
    Inventors: Joseph H. Smith, David H. Persing, Alan Wortman, Ronald Chang, David Swenson
  • Methods of detecting cervical cancer
    Patent number: 10000808
    Abstract: Methods of detecting cervical dysplasia, such as cervical dysplasia likely to progress to carcinoma in a sample of human cervical cells, are provided. Methods of detecting changes in expression of one or more microRNAs or mRNAs associated with cervical dysplasia or cervical cancer are also provided. Compositions and kits are also provided.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: June 19, 2018
    Assignee: Cepheid
    Inventors: Cecilia Svanholm Barrie, Olivier Delfour, David H. Persing
  • Methods and apparatus for sequential amplification reactions
    Patent number: 9873909
    Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: January 23, 2018
    Assignee: Cepheid
    Inventors: Joseph H. Smith, David H. Persing, Alan Wortman, Ronald Chang, David Swenson
  • Methods of detecting sepsis
    Patent number: 9493832
    Abstract: Methods of detecting sepsis in a sample from a patient are provided. Methods of detecting changes in expression of one or more microRNAs associated with sepsis are also provided. Compositions and kits are also provided.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: November 15, 2016
    Assignee: Cepheid
    Inventors: David Vilanova, David H. Persing, Olivier Delfour, Bernard Michot
  • METHODS OF DETECTING LUNG CANCER
    Publication number: 20150376711
    Abstract: Methods of lung cancer in a sample from a patient are provided. Methods of detecting changes in expression of one or more target RNAs associated with lung cancer are also provided. Compositions and kits are also provided.
    Type: Application
    Filed: May 26, 2015
    Publication date: December 31, 2015
    Applicant: CEPHEID
    Inventors: Bernard Michot, Olivier Delfour, David H. Persing
  • METHODS AND APPARATUS FOR SEQUENTIAL AMPLIFICATION REACTIONS
    Publication number: 20150176057
    Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
    Type: Application
    Filed: November 25, 2014
    Publication date: June 25, 2015
    Inventors: Joseph H. Smith, David H. Persing, Alan Wortman, Ronald Chang, David Swenson
  • Methods of Detecting Cervical Cancer
    Publication number: 20150051103
    Abstract: Methods of detecting cervical dysplasia, such as cervical dysplasia likely to progress to carcinoma in a sample of human cervical cells, are provided. Methods of detecting changes in expression of one or more microRNAs or mRNAs associated with cervical dysplasia or cervical cancer are also provided. Compositions and kits are also provided.
    Type: Application
    Filed: July 29, 2014
    Publication date: February 19, 2015
    Inventors: Cecilia Svanholm Barrie, Olivier Delfour, David H. Persing
  • Methods and apparatus for sequential amplification reactions
    Patent number: 8900828
    Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: December 2, 2014
    Assignee: Cepheid
    Inventors: Joseph H. Smith, David H. Persing, Alan Wortman, Ronald Chang, David Swenson
  • METHODS OF DETECTING LUNG CANCER
    Publication number: 20140200153
    Abstract: Methods of lung cancer in a sample from a patient are provided. Methods of detecting changes in expression of one or more target RNAs associated with lung cancer are also provided. Compositions and kits are also provided.
    Type: Application
    Filed: November 14, 2013
    Publication date: July 17, 2014
    Applicant: Cepheid
    Inventors: Bernard Michot, Olivier Delfour, David H. Persing
  • METHODS OF DETECTING LUNG CANCER
    Publication number: 20130157886
    Abstract: Methods of lung cancer in a sample from a patient are provided. Methods of detecting changes in expression of one or more target RNAs associated with lung cancer are also provided. Compositions and kits are also provided.
    Type: Application
    Filed: November 26, 2012
    Publication date: June 20, 2013
    Inventors: Bernard MICHOT, Olivier DELFOUR, David H. PERSING
  • Methods of Detecting Cervical Cancer
    Publication number: 20130102488
    Abstract: Methods of detecting cervical dysplasia, such as cervical dysplasia likely to progress to carcinoma in a sample of human cervical cells, are provided. Methods of detecting changes in expression of one or more microRNAs or mRNAs associated with cervical dysplasia or cervical cancer are also provided. Compositions and kits are also provided.
    Type: Application
    Filed: October 23, 2012
    Publication date: April 25, 2013
    Inventors: Cecilia Svanholm Barrie, Olivier Delfour, David H. Persing
  • Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds
    Patent number: 8318697
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: November 27, 2012
    Assignee: Corixa Corporation
    Inventors: David H. Persing, Richard Thomas Crane, Gary T. Elliott, J. Terry Ulrich, Michael J. Lacy, David A. Johnson, Jory R. Baldridge, Rong Wang
  • PROPHYLACTIC AND THERAPEUTIC TREATMENT OF INFECTIOUS AND OTHER DISEASES WITH MONO- AND DISACCHARIDE-BASED COMPOUNDS
    Publication number: 20110178034
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
    Type: Application
    Filed: March 7, 2011
    Publication date: July 21, 2011
    Applicant: Corixa Corporation
    Inventors: David H. Persing, Richard T. Crane, Gary T. Elliot, J. Terry Ulrich, Michael J. Lacy, David A. Johnson, Jory R. Baldridge, Rong Wang
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF BREAST CANCER
    Publication number: 20110150883
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: October 30, 2007
    Publication date: June 23, 2011
    Applicant: CORIXA CORPORATION
    Inventors: Gary R. Fanger, Shannon Kathleen Hirst, Davin C. Dillon, Teresa M. Foy, Raymond L. Houghton, David H. Persing, Michael D. Kalos
  • Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds
    Patent number: 7902159
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: March 8, 2011
    Assignee: Corixa Corporation
    Inventors: David H. Persing, Richard Thomas Crane, Gary T. Elliot, J. Terry Ulrich, Michael J. Lacy, David A. Johnson, Jory R. Baldridge, Rong Wang