Abstract: A computer input system includes a mouse including a housing having an interior surface defining an internal volume and a sensor assembly disposed in the internal volume. A processor is electrically coupled to the sensor assembly and a memory component having electronic instructions stored thereon that, when executed by the processor, causes the processor to determine an orientation of the mouse relative to a hand based on a touch input from the hand detected by the sensor assembly. The mouse can also have a circular array of touch sensors or lights that detect hand position and provide orientation information to the user.

Abstract: The present invention provides methods for providing a prognosis for lung adenocarcinoma, using a panel of eight molecular markers that are differentially expressed in lung adenocarcinoma.

Abstract: A method includes obtaining a plurality of training samples that each include a respective speech utterance and a respective textual utterance representing a transcription of the respective speech utterance. The method also includes fine-tuning, using quantization and sparsity aware training with native integer operations, a pre-trained automatic speech recognition (ASR) model on the plurality of training samples. Here, the pre-trained ASR model includes a plurality of weights and the fine-tuning includes pruning one or more weights of the plurality of weights using a sparsity mask and quantizing each weight of the plurality of weights based on an integer with a fixed-bit width. The method also includes providing the fine-tuned ASR model to a user device.

Abstract: A respiratory obstruction removal device, which includes a face mask and a negative pressure generating device. The negative pressure generating device includes a grip section, an extendable tubular body, and an annular interface, connected in sequence. The extendable tubular body has a variable volume cavity. The face mask includes an upper part that fits with the annular interface, a lower part that corresponds to a face of a patient, and a connecting body that links the upper and lower parts. The respiratory obstruction removal device also includes a first one-way valve located on the annular interface and a second one-way valve for unidirectional expulsion of gas to the outside. The grip portion and the extendable tubular body are detachably connected. This design is efficient and easy to carry and transport, suitable for emergency use in different scenarios.

Abstract: This invention relates to berberine alkaloids, formulations thereof, and their use in the prevention and/or treatment of infectious disease in animals, particularly Lawsonia infection. In particular, the invention relates to berberine alkaloids, formulations thereof, and their application as antimicrobial agents in the prevention and/or treatment of infectious disease including bacterial, viral, parasitic or fungal infections, and for improving feed conversion ratio in food-producing animals. Also described is the use of berberine alkaloids as feed preservatives, added to feed compositions, and used in combination with further agents suitable for treating infectious disease.

Abstract: The present disclosure provides compounds, pharmaceutical compositions, and methods for the treatment of cancer and fibrosis. The disclosed pharmaceutical compositions may include one or more pyrazolyl-containing compounds, or a derivative thereof.

Abstract: A system predicts metadata attributes associated with documents using machine learning models. The document may represent an interaction between entities. The system trains machine learning models to predict scores indicating whether a token or a sequence of token of a document represents a metadata attribute. The metadata prediction is used to annotate the document and display to users. The system receives user feedback via the user interface and uses the user feedback to evaluate or retrain the model. The system generates training data by receiving a set of annotated documents and comparing the annotated documents against other documents to identify matching documents. The system determines when to execute the machine learning based metadata prediction based on steps of document workflow executed by the system.

Abstract: The present disclosure relates to augmented reality devices and related methods. The augmented reality devices include a projection system. The projection system includes a projector including a major axis. The projected is configured to project an image along the major axis. A prism is configured to refract the image. The image includes a first spectrum, a second spectrum, and a third spectrum. A waveguide is disposed at a wrap angle from a plane formed from the major axis of the projector. The waveguide includes an input coupler, and an output coupler.

Abstract: A particulate filter having a honeycomb structure of a matrix of interconnected porous walls including inlet cells and outlet cells defining a plurality of inlet channels and outlet channels, respectively, wherein at least a portion of the outlet cells are larger than any of the inlet cells, and a cross-sectional shape of at least some of the outlet channels is rectangular. Honeycomb extrusion dies, honeycomb bodies, honeycomb structures, and methods of manufacture are described, as are other aspects.

Abstract: The disclosure relates to nitroimidazoles and related compounds and derivatives, formulations thereof, and their use in the prevention and/or treatment of infectious disease in animals. In particular, the disclosure relates to 5-nitroimidazoles and related compounds and derivatives, formulations thereof, and their use in the prevention and/or treatment of infectious disease in animals including bacterial, viral, parasitic or fungal infections. More particularly, the invention relates to metronidazole and related compounds and derivatives, formulations thereof, and their use in the prevention and/or treatment of infectious disease caused by Clostridium species. Most preferably, the nitroimidazole is metronidazole administered in combination with berberine, or a berberine alkaloid, in a synergistic weight ratio of 1:1 or 1:2.

Abstract: The present disclosure relates to augmented reality devices and related methods. In one or more embodiments, an augmented reality device includes a projection system and a waveguide. The projection system includes a projector and a prism. The projector projects an image along the projectors major axis. The prism refracts the image having a first spectrum, a second spectrum, and a third spectrum. The waveguide is disposed at a wrap angle from a plane formed from the major axis of the projector. The waveguide includes an input coupler and an output coupler. The input coupler includes input structures at an input period and an input orientation and the input coupler is configured to receive the spectrums at different corresponding input angles. The output coupler includes output structures at an output period and an output orientation and the output coupler out couples the respective spectrums at an about equal output angle.

Abstract: A drill bit for cutting formation comprises a bit body, a plurality of cutters, and a plurality of blades with pockets to accommodate the cutters, respectively. In an embodiment, the plurality of cutters comprise a substrate, an ultra-hard layer, a concave surface on the top of the ultra-hard layer, wherein the concave surface comprises a plurality of planar and curved surfaces.

Abstract: Various examples are described for detecting heart rate and respiratory rate by using measurements of light applied to skin through an article. For example, a sensor application obtains a set of measurements of light. The application compensates for a contribution of the article based on one or more known optical properties of the article. The sensor application further determines, from the set of measurements of light, a periodic change in amplitude. The sensor application identifies the periodic change in amplitude as a heart rate having an identical periodicity. The sensor application identifies a respiratory rate as equal to the rate of change of the heart rate.

Abstract: A finger wearable device for monitoring vital signs at a finger includes a housing, a finger cuff, a plurality of vital sign sensors, and an electrocardiogram (ECG) sensor. The housing includes an interface surface for pressing against the finger. The finger cuff attaches to the housing and has a size and a shape to secure the housing to the finger and force the interface surface against the finger when the finger cuff is worn around the finger. The vital sign sensors are disposed in or on the housing and orientated to measure the vital signs from the finger of a wearer. The ECG sensor is disposed in or on the housing and coupled to first and second electrodes to measure ECG signals. The second electrode is disposed on the interface surface.

Abstract: Various examples are described for detecting heart rate and respiratory rate by using measurements of light applied to skin through an article. For example, a sensor application obtains a set of measurements of light. The application compensates for a contribution of the article based on one or more known optical properties of the article. The sensor application further determines, from the set of measurements of light, a periodic change in amplitude. The sensor application identifies the periodic change in amplitude as a heart rate having an identical periodicity. The sensor application identifies a respiratory rate as equal to the rate of change of the heart rate.

Abstract: Various examples are described for using a movement sensor to detecting an activity of an infant. In an example, an activity classification system includes a sensor configured to measure the activity of an infant and an external monitor. The monitor receives, from a sensor, a time series of data comprising an inertial measurement for each a time period. The monitor determines, from the time series and by using a predictive model, an activity from a list of identified activities. Examples of identified activities are deep sleep, light sleep, sitting, awake, nursing, or bottle feeding.

Abstract: One disclosed example method includes receiving sensor data from a biosensor; determining an event using a first analysis based on the sensor data, the first analysis having a first power cost; determining to perform a second analysis based on the event; in response to determining to perform the second analysis, performing the second analysis based on the sensor data, the second analysis having a second power cost greater than the first power cost; and wirelessly transmitting results of the second analysis to a remote device.

Abstract: Various examples of a wearable sensor enclosure are described. In an example, a wearable sensor enclosure is generally oval-shaped with rigid interior that protects one or more sensors or other electronic devices. The enclosure includes a proximal component and a distal component. The proximal component of the enclosure optionally includes one or more openings for light to pass through for detection by sensing electronic devices. The distal component includes a protrusion positioned in an interior of the distal component and a lip positioned in along the perimeter of the distal component such that the lip surrounds the protrusion.

Abstract: A drill bit for cutting formation comprises a bit body, a plurality of cutters, and a plurality of blades with pockets to accommodate the cutters, respectively. In an embodiment, the plurality of cutters comprise a substrate, an ultra-hard layer, a concave surface on the top of the ultra-hard layer, wherein the concave surface comprises a plurality of planar and curved surfaces.

Abstract: An acid resistant capsule comprises at least one hard capsule shell, said shell comprising: an enteric polymer having acid groups; a film-forming aid; and an alkaline material, wherein said alkaline material is present in an amount such that said carboxylic acid groups of said enteric polymer have a degree of ionization of less than 15%.