Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a seat, such as a chair or stool, which comprises a frame including at least one leg, an undercarriage which is configured to receive the leg, and a seat pan. The seat pan is rotatably mounted to the undercarriage, wherein the seat pan is rotatable about an axis of rotation relative to the undercarriage. The undercarriage also includes a recess and a resilient component in the recess, while the seat pan includes a stop located on a bottom surface of the seat pan. On rotation of the seat pan relative to the undercarriage, such as may occur when the person seated leans forward or back, the resilient component is compressed between the undercarriage and the stop. In one embodiment, an axle passes through the axis of rotation and connects the legs, and potentially backrest if present, to the undercarriage.

Abstract: A brake arrangement for a vehicle comprising a braking system arranged to vary hydraulic or pneumatic brake pressure that is arranged to apply a pressure to a brake caliper; an electric motor arranged to generate a braking torque that is applied to a first wheel when the electric motor is placed in a braking mode of operation, wherein the electric motor is arranged to vary brake torque generated when the electric motor is in the braking mode dependent upon a predetermined operating condition of the braking system.

Abstract: A force sensing element is used in a pressure transducer. The force sensing element includes a flat, disc-type spring having a unitary body that circumscribes a central axis, and a plurality of spirals that are continuous with each other and extend radially outwardly from the central axis. The plurality of spirals includes nested symmetrical flights having walls with a non-uniform thickness, and the disc spring is uniformly deflectable along the central axis in response to force acting on the disc-type spring. The spring is configured to have a high accuracy and a high fatigue life such that the spring is suitable for use in high-pressure applications that may require repeatability while operating with over 10 million cycles of unidirectional or bi-directional axial loading.

Abstract: A control system for a vehicle having a first wheel (101) arranged to be driven by a first drive source and a second wheel (101) arranged to be driven by a second drive source, wherein the first wheel and the second wheel are transversely located on the vehicle, the control system comprising a controller (102) and a monitoring device, wherein the monitoring device is arranged to monitor the power differential between the power being applied to the first wheel by the first drive source and the power being applied to the second wheel by the second drive source, wherein upon a determination that the power differential between the power being applied to the first wheel and the second wheel is greater than a predetermined value, the controller is arranged to reduce the power differential.

Abstract: A method includes dividing, at a cable modem termination system, a transmit stream into multiple data streams. The multiple data streams include a first data stream and a second data stream. Each of the multiple data streams has a lower bit rate than a bit rate of the transmit stream. The method includes transmitting, via the cable modem termination system, the first data stream over at least a first channel of a group of channels. The method also includes transmitting, via the cable modem termination system, the second data stream over at least a second channel of the group of channels. The group of channels supports traffic to a plurality of destinations. The first channel and the second channel are frequency-division multiplexed channels.

Abstract: A thoracic catheter system comprises a flexible thoracic catheter for inserting into a thoracic cavity of a human. A distal end of the thoracic catheter has a plurality of apertures. A proximate end of the thoracic catheter is designed to extend out of the thoracic cavity. A three way valve is one of fused with and removably attached to the proximal end of the thoracic catheter.

Abstract: A medical stopcock which allows easier switching operation of plural branch-tubes. The main body of the stopcock comprises a chamber part with a nearly spherical inner surface, and an upstream branch-tube, a downstream branch-tube and a merge-branch-tube all extending from the chamber part. A valve body of the stopcock comprises a nearly spherical valve main body and a rod-shaped operating part with a guide hole linking the inner surface of the chamber part to the outside. In operation, the rod-shaped operating part is moved along the guide hole through the use of the horizontal flow passages and the vertical flow passage to allow the predetermined branch-tubes out of the upstream branch-tube, the downstream branch-tube and the merge-branch-tube to communicate with one another or to shut-off the communication.

Abstract: A method includes dividing, at a cable modem termination system, a transmit stream into multiple data streams. The multiple data streams include a first data stream and a second data stream. Each of the multiple data streams has a lower bit rate than a bit rate of the transmit stream. The method includes transmitting, via the cable modem termination system, the first data stream over at least a first channel of a group of channels. The method also includes transmitting, via the cable modem termination system, the second data stream over at least a second channel of the group of channels. The group of channels supports traffic to a plurality of destinations. The first channel and the second channel are frequency-division multiplexed channels.

Abstract: A control system for a vehicle having a first wheel (101) arranged to be driven by a first drive source and a second wheel (101) arranged to be driven by a second drive source, wherein the first wheel and the second wheel are transversely located on the vehicle, the control system comprising a controller (102) and a monitoring device, wherein the monitoring device is arranged to monitor the power differential between the power being applied to the first wheel by the first drive source and the power being applied to the second wheel by the second drive source, wherein upon a determination that the power differential between the power being applied to the first wheel and the second wheel is greater than a predetermined value, the controller is arranged to reduce the power differential.