Abstract: An off-highway recreational vehicle includes side-by-side passenger and driver seats held within a chassis. The seats sit low in the chassis and are covered by a roll-over protection system (ROPS), The vehicle is powered by an engine rearward of the seats that utilizes a continuously variable transmission (CVT) to provide power to the ground engaging members, wherein the CVT is cooled via air captured by a CVT intake body located adjacent the driver-side seat, between the frame and external panels of the utility vehicle.

Abstract: Provided herein are, inter alia, antibodies capable of binding Structural Maintenance of Chromosome-1 (SMC1). The antibodies provided herein include novel light chain and heavy chain sequences and bind SMC1 (e.g., SMC1A or SMC1B) with high efficiency and specificity. The SMC1 antibodies provided herein including embodiments thereof may be used for diagnostic and therapeutic purposes, for example, as humanized SMC1 antibodies, antibody drug conjugates or they may form part of bispecific antibodies or chimeric antigen receptors.

Abstract: Described herein, inter alia, are IGF2BP2 inhibitor compounds and methods of using the same.

Abstract: An orthopaedic joint prosthesis assembly includes a head part of an orthopaedic joint prosthesis component and an alignment guide. The head part has a spherical bearing surface for articulation with a corresponding joint surface, and an assembly surface having a first bore formed in it for receiving a spigot on another part of the orthopaedic joint prosthesis. The bore has a first axis that extends perpendicular to the assembly surface. The alignment guide has an axial portion defining a second axis and an arm extending from the axial portion. The arm includes a distal portion which is configured to engage the assembly surface, with the axial portion being arranged to engage the bearing surface of the head part when the head part is mounted within the guide such that an impaction force applied along the second axis is directed along the first axis.

Abstract: Disclosed and provided herein are, inter alia, compounds of formula (Ia), (Ib), or (Ic): or pharmaceutically acceptable salts or stereoisomers thereof, and use thereof in methods for modulating CREB binding protein (CBP)/catenin signaling pathway activity and treating CBP/?-catenin mediated disorders.

Abstract: A method of manufacturing an orthopaedic prosthetic component can include identifying a porous three-dimensional Voronoi structure shaped to be implanted in a patient's body. The porous three-dimensional Voronoi structure can include a plurality of struts, a number of pores, a first surface, and a second surface. The plurality of struts can define randomized interconnected organicized cells. Respective groups of struts intersect so as to define a respective plurality of nodes. The method can include the step of modifying modifying at least one of the struts or at least one of the nodes such that the porous three-dimensional structure comprises a lattice structure other than a Voronoi pattern. Instructions can then be generated to fabricate the porous three-dimensional structure.

Abstract: Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

Abstract: An orthopaedic joint prosthesis assembly includes a head part of an orthopaedic joint prosthesis component and an alignment guide. The head part has a spherical bearing surface for articulation with a corresponding joint surface, and an assembly surface having a first bore formed in it for receiving a spigot on another part of the orthopaedic joint prosthesis. The bore has a first axis that extends perpendicular to the assembly surface. The alignment guide has an axial portion defining a second axis and an arm extending from the axial portion. The arm includes a distal portion which is configured to engage the assembly surface, with the axial portion being arranged to engage the bearing surface of the head part when the head part is mounted within the guide such that an impaction force applied along the second axis is directed along the first axis.

Abstract: An off-highway recreational vehicle includes side-by-side passenger and driver seats held within a chassis. The seats sit low in the chassis and are covered by a roll-over protection system (ROPS), The vehicle is powered by an engine rearward of the seats that utilizes a continuously variable transmission (CVT) to provide power to the ground engaging members, wherein the CVT is cooled via air captured by a CVT intake body located adjacent the driver-side seat, between the frame and external panels of the utility vehicle.

Abstract: Kits and methods for use in intraoperative trialling of hip prostheses to determine an appropriate length for the femoral neck component of a prosthetic hip joint, are described. A kit for use in selecting a femoral neck component of an orthopaedic joint prosthesis kit comprises a first and a second broach. Each of the first and second broaches has a neck connection element comprising a projection extending from a proximal surface of the broach, each projection having a length. The projection on the first broach has a different length than the projection on the second broach. The kit also includes a trial femoral neck component having a neck connection element in the form of a recess in a distal surface.

Abstract: An off-highway recreational vehicle includes side-by-side passenger and driver seats held within a chassis. The seats sit low in the chassis and are covered by a roll-over protection system (ROPS). The vehicle is powered by an engine rearward of the seats that utilizes a continuously variable transmission (CVT) to provide power to the ground engaging members, wherein the CVT is cooled via air captured by a CVT intake body located adjacent the driver-side seat, between the frame and external panels of the utility vehicle.

Abstract: Described herein, inter alia, are clock activators and uses thereof.

Abstract: A surgical rotational tool driver and method. The driver includes a driveline extending within a hollow shaft and a head part including connection features for connecting to a connection member of a surgical rotational tool. The connection features of the head part include a housing and a pair of jaw member each including jaws for receiving the connection member. Each jaw member is pivotally mounted for rotation between: a first position for receipt of the connection member and a second position for retaining the connection member. The connection features of the head part further include a locking mechanism including a pair of catches for engaging with a respective catch of each jaw member to lock the jaw members in the second position. The locking mechanism also includes a release member slideably moveable within the housing to release the catches of the locking mechanism from the catches of the jaw members.

Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments covalently linked to a peptide compound through a disulfide linkage. The disulfide linkage is between a cysteine in the Fab region of the antibody or fragment thereof and a thiol moiety of a side chain amino acid of the peptide compound. The covalently formed complexes including provided herein form highly stable and versatile drug delivery and diagnostic compositions.

Abstract: Kits and methods for use in intraoperative trialling of hip prostheses to determine an appropriate length for the femoral neck component of a prosthetic hip joint, are described. A kit for use in selecting a femoral neck component of an orthopaedic joint prosthesis kit comprises a first and a second broach. Each of the first and second broaches has a neck connection element comprising a projection extending from a proximal surface of the broach, each projection having a length. The projection on the first broach has a different length than the projection on the second broach. The kit also includes a trial femoral neck component having a neck connection element in the form of a recess in a distal surface.

Abstract: A surgical rotational tool driver and method. The driver includes a driveline extending within a hollow shaft and a head part including connection features for connecting to a connection member of a surgical rotational tool. The connection features of the head part include a housing and a pair of jaw member each including jaws for receiving the connection member. Each jaw member is pivotally mounted for rotation between: a first position for receipt of the connection member and a second position for retaining the connection member. The connection features of the head part further include a locking mechanism including a pair of catches for engaging with a respective catch of each jaw member to lock the jaw members in the second position. The locking mechanism also includes a release member slideably moveable within the housing to release the catches of the locking mechanism from the catches of the jaw members.

Abstract: An acetabular reamer handle including a shaft having a distal end, a neck part having a longitudinal axis, a driveline extending through the shaft and the neck part, and a locking mechanism. A distally located head part of the driveline is mounted for rotation about the longitudinal axis of the neck part and is connectable to a reamer. The distal end of the shaft and a proximal end of the neck part are pivotally attached to allow the shaft to be tilted relative to the longitudinal axis. The tilting can allow part of the acetabulum and/or reamer that is otherwise obscured to be viewed. The locking mechanism includes an engagement member having an engagement surface located at the distal end of the shaft. The engagement member is moveable distally to urge the engagement surface against the proximal end of the neck part.

Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments, including those where a Fab-binding molecule (Fab binding moiety) linked to a steric hindering molecule (steric hindering chemical moiety) is mechanically interlocked (e.g., through noncovalent conjugation) with the antibody or antibody fragment. Also provided are compositions that form highly stable and versatile drug delivery and diagnostic compositions.

Abstract: Provided herein are, inter alia, methods of treating cancer using compounds of the invention.

Abstract: Devices, methods and a system for detection and analysis of inhaler use, in particular breath detection modules and inhaler device counters. An electronic inhaler counter device (100) comprises a rocker arm (102) comprising a proximal end (110) providing a pivot (104) and a distal end (112) providing a head (114), a return spring (108) coupled to the rocker arm pivot, and a count switch (106), wherein, in response to a first selected degree of linear actuation motion, the rocker arm is arranged to perform a first rocker movement and engage the count switch with the rocker head; and in response to further linear actuation motion, the spring is engaged to enable the rocker arm to perform a second rocker movement, such to facilitate over travel.