Abstract: Disclosed herein are, inter alia, compounds modulating activity and methods of use thereof for treating CBP/?-catenin mediated disorders.

Abstract: Described herein, inter alia, are IGF2BP2 inhibitor compounds and methods of using the same.

Abstract: Kits and methods for use in intraoperative trialling of hip prostheses to determine an appropriate length for the femoral neck component of a prosthetic hip joint, are described. A kit for use in selecting a femoral neck component of an orthopaedic joint prosthesis kit comprises a first and a second broach. Each of the first and second broaches has a neck connection element comprising a projection extending from a proximal surface of the broach, each projection having a length. The projection on the first broach has a different length than the projection on the second broach. The kit also includes a trial femoral neck component having a neck connection element in the form of a recess in a distal surface.

Abstract: Disclosed herein, inter alia, are compositions and methods of using the same for the treatment of cancer.

Abstract: One aspect of the disclosure relates to the use of derivatives of dichlorophenyl urea for treating cancers.

Abstract: Provided herein are compositions including methylene bis[4,4?-(2-chlorophenylureidophenoxyisobutyric acid)] (LR-90) or a pharmaceutically acceptable salt or derivative thereof and methods of use thereof for treating and/or preventing chemotherapy-induced neuropathic pain in a subject in need thereof.

Abstract: An off-highway recreational vehicle includes side-by-side passenger and driver seats held within a chassis. The seats sit low in the chassis and are covered by a roll-over protection system (ROPS). The vehicle is powered by an engine rearward of the seats that utilizes a continuously variable transmission (CVT) to provide power to the ground engaging members, wherein the CVT is cooled via air captured by a CVT intake body located adjacent the driver-side seat, between the frame and external panels of the utility vehicle.

Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

Abstract: The present disclosure relates to catalytic static mixers comprising catalytic material. The static mixers can be configured for use with continuous flow chemical reactors, for example tubular continuous flow chemical reactors for heterogeneous catalysis reactions. This disclosure also relates to processes for preparing static mixers. This disclosure also relates to continuous flow chemical reactors comprising the static mixers, systems comprising the continuous flow chemical reactors, processes for synthesising products using the continuous flow reactors, and methods for screening catalytic materials using the static mixers.

Abstract: Provided herein are methods for treating metastatic prostate cancer using anti-androgen compounds and radionuclide-labeled androgens.

Abstract: Provided, inter alia, are methods and compositions for treating FTO-mediated cancer.

Abstract: Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

Abstract: A warp knitted mesh fabric constructed of synthetic, or synthetic and natural, fibers is characterized by having a low density, open construction with a high profile for spacing a garment constructed from the fabric from the skin of a wearer of the garment.

Abstract: An off-highway recreational vehicle includes side-by-side passenger and driver seats held within a chassis. The seats sit low in the chassis and are covered by a roll-over protection system (ROPS). The vehicle is powered by an engine rearward of the seats that utilizes a continuously variable transmission (CVT) to provide power to the ground engaging members, wherein the CVT is cooled via air captured by a CVT intake body located adjacent the driver-side seat, between the frame and external panels of the utility vehicle.

Abstract: Provided herein are solution formulations of CX-011 and related methods for making solution formulations of CX-011. Also provided are methods of treating an inflammatory disorder, such as osteoarthritis, or cancer in a subject in need thereof by administering an effective amount of the solution formulations of CX-011.

Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.

Abstract: The present disclosure relates to catalytic static mixers comprising catalytic material. The static mixers can be configured for use with continuous flow chemical reactors, for example tubular continuous flow chemical reactors for heterogeneous catalysis reactions. This disclosure also relates to processes for preparing static mixers. This disclosure also relates to continuous flow chemical reactors comprising the static mixers, systems comprising the continuous flow chemical reactors, processes for synthesising products using the continuous flow reactors, and methods for screening catalytic materials using the static mixers.

Abstract: A surgical rotational tool driver and method. The driver includes a driveline extending within a hollow shaft and a head part including connection features for connecting to a connection member of a surgical rotational tool. The connection features of the head part include a housing and a pair of jaw member each including jaws for receiving the connection member. Each jaw member is pivotally mounted for rotation between: a first position for receipt of the connection member and a second position for retaining the connection member. The connection features of the head part further include a locking mechanism including a pair of catches for engaging with a respective catch of each jaw member to lock the jaw members in the second position. The locking mechanism also includes a release member slideably moveable within the housing to release the catches of the locking mechanism from the catches of the jaw members.

Abstract: Chimeric antigen receptors targeted to CD33 are described together with their use in treating various cancers and in reducing myeloid derived suppressor cells in a patient.

Abstract: Kits and methods for use in intraoperative trailing of hip prostheses to determine an appropriate length for the femoral neck component of a prosthetic hip joint, are described. A kit for use in selecting a femoral neck component of an orthopaedic joint prosthesis kit comprises a first (10) and a second (110) broach. Each of the first and second broaches has a neck connection element comprising a projection (12, 112) extending from a proximal surface (14, 114) of the broach, each projection having a length (L). The projection on the first broach has a different length than the projection on the second broach. The kit also includes a trial femoral neck (30) component having a neck connection element in the form of a recess (36) in a distal surface (34).