Abstract: An acetabular reamer handle and a method of reaming an acetabulum. The handle includes a hollow shaft having a plurality of shaft sections including a distal shaft section having a distal end and a proximal end and an additional shaft section having a distal end that is pivotally attached to the proximal end of the distal shaft section to allow the additional shaft section and the distal shaft section to be adjustably oriented at an angle. The handle also includes a hollow neck part having a longitudinal axis. The handle further includes a drive line having a head part mounted for rotation about the longitudinal axis and connectable to a reamer. A distal end of the distal shaft section is pivotally attached to a proximal end of the neck part to allow the distal shaft section and the neck part to be adjustably oriented at an angle.

Abstract: The invention provides an impactor for transmitting an assembly force to a component of an orthopaedic implant. The impactor has first and second telescoping parts which are biased apart by means of a main spring. The main spring is compressed when an assembly force is applied to the parts. An indicator is latched against movement until it is released when the extent of the compression of the main spring by the application of an assembly force exceeds a threshold. The indicator then moves to provide the user with an indication that a minimum assembly force has been applied.

Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments covalently linked to a peptide compound through a disulfide linkage. The disulfide linkage is between a cysteine in the Fab region of the antibody or fragment thereof and a thiol moiety of a side chain amino acid of the peptide compound. The covalently formed complexes including provided herein form highly stable and versatile drug delivery and diagnostic compositions.

Abstract: Kits and methods for use in intraoperative trailing of hip prostheses to determine an appropriate length for the femoral neck component of a prosthetic hip joint, are described. A kit for use in selecting a femoral neck component of an orthopaedic joint prosthesis kit comprises a first (10) and a second (110) broach. Each of the first and second broaches has a neck connection element comprising a projection (12, 112) extending from a proximal surface (14, 114) of the broach, each projection having a length (L). The projection on the first broach has a different length than the projection on the second broach. The kit also includes a trial femoral neck (30) component having a neck connection element in the form of a recess (36) in a distal surface (34).

Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using thioindirubin derivatives.

Abstract: Disclosed herein, inter alia, are compositions and methods of using the same for the treatment of cancer.

Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.

Abstract: Provided herein, inter alia, is the synthesis of ETP derivatives. The synthesis methods described herein include converting a ring bridging trisulfide compound to a ring bridging disulfide compound. Also provided herein are compositions, which include ring bridging trisulfide compounds and ring bridging disulfide compounds.

Abstract: Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

Abstract: Disclosed herein are compositions and methods for treating cancer, FLT3-AML, and CML.

Abstract: The invention provides an osteotome which includes a curved guide member extending distally from its medial side. This curved guide member interfaces with the medial curvature of the femoral canal. The guide member guides the osteotome using the internal bone geometry of the femoral canal instead of relying on external anatomical landmarks.

Abstract: Provided herein are methods for treating metastatic prostate cancer using anti-androgen compounds and radionuclide-labeled androgens.

Abstract: The invention provides a reamer handle comprising: a shank having a distal tool coupling end adapted to releasably couple to a part of a surgical tool and a proximal end; a retractable catch which is linearly displaceable along the shank between a non-retracted position in which the catch captures the surgical tool within the distal tool coupling end of the tool holder and a retracted position in which the catch enables the tool to be released from the distal tool coupling end; a biasing member configured to bias the catch in the non-retracted position; and a sleeve extending along the shank. The sleeve comprises: a distally located catch contacting portion and a proximally located handle portion for manually displacing the sleeve relative to the shank such that displacement of the catch contacting portion moves the retractable catch between the non-retracted position and the retracted position to enable capture and release of the tool from the tool holder.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Provided herein are methods for treating metastatic prostate cancer using anti-androgen compounds and radionuclide-labeled androgens.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: A surgical rotational cutting tool, a surgical kit and a method of preparing a femur to receive a stem of a femoral prosthetic. The tool includes a longitudinal axis and a shaft extending along the longitudinal axis, which has a proximal end and a distal end. The tool also includes a head located at the distal end of the shaft. The head includes a pointed distal tip, a bone contacting outer surface having a portion which curves inwards toward the longitudinal axis as it approaches the tip, and a plurality of flutes. The edges of distal parts of neighbouring pairs of the flutes meet to define a plurality of cutting edges which extend proximally from the pointed distal tip. A proximal part of each flute extends proximally across the curved portion.

Abstract: Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

Abstract: The present disclosure relates to catalytic static mixers comprising catalytic material. The static mixers can be configured for use with continuous flow chemical reactors, for example tubular continuous flow chemical reactors for heterogeneous catalysis reactions. This disclosure also relates to processes for preparing static mixers. This disclosure also relates to continuous flow chemical reactors comprising the static mixers, systems comprising the continuous flow chemical reactors, processes for synthesising products using the continuous flow reactors, and methods for screening catalytic materials using the static mixers.

Abstract: Provided herein, inter alia, are methods of treating cancer in a subject, by administering COH29 ((N-(4-(3,4-dihydroxyphenyl)-5-phenylthia-zol-2-yl)-3,4-dihydroxybenzamide)).