Abstract: In an example embodiment of the disclosed technology, a plant disinfection apparatus is provided that may comprise a support device configured to directly or indirectly support one or more UVC probes beneath the support device. The one or more UVC probes may each comprise a relatively elongated shape comprising a major axis Y, a light source that emits UVC light in a predominantly perpendicular distribution pattern relative to axis Y, and a suspension device configured to directly or indirectly attach to the support device. The UVC probe may be configured to be raised and lowered in a relatively vertical orientation and may further comprise a means of conveying power to the UVC light source. The one or more UVC probes may be configured to be lowered into the foliage of one or more plants disposed beneath the plant disinfection apparatus.

Abstract: In various embodiments, the present disclosure relates generally to gaming systems and methods that concurrently display one or more aspects of a primary game and a play of a secondary game within the limited display space available of an electronic gaming machine with a single display device.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an immunomodulator.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an integrin inhibitor. In particular, the disclosure features the topical treatment of sections and subsections of the gastrointestinal tract by integrin inhibitors (like vedolizumab) using an ingestible device that can detect its whereabouts in the Gl tract by using reflectance and which is programmed to release the drugs at a given site or proximal thereto, to treat gastrointestinal inflammatory diseases. The device has hardware storage devices with instructions on board to determine the location and release the formulations. Combination therapies are claimed as well in which the integrin inhibitor is added systemically and another agent (e.g. JAK inhibitor, TNF-alpha inhibitor or IL-12/IL-23 inhibitor) is added topically by means of the ingestible device. The topical administration is said to reduce the side effects associated with systemic treatment.

Abstract: This disclosure features methods and compositions for treating inflammatory disorders or conditions that arise in a tissue originating from the endoderm using an immune modulator.

Abstract: An example embodiment of an upper room air germicidal light fixture may comprise a light source configured to emit germicidal light and may further comprise one or more lower and upper baffle assemblies disposed adjacent to the light source. Said upper and lower baffle assemblies may be configured to enable air to flow through them and to block or substantially dissipate incident light rays from the light source. One or more apertures may be defined by the openings between a corresponding set of upper and lower baffle assemblies, wherein said light can exit the fixture through said apertures. When the germicidal light fixture is disposed in a room, surrounding room air may contact light exiting the apertures of said fixture, and room air traveling through said fixture may contact light inside and between the one or more upper and lower baffle assemblies.

Abstract: An apparatus for the formation of machine-made tobacco rods for use in the production of smoking articles, such as cigars, from tobacco comprising a tacky material. The apparatus includes a pair of transfer and compression belts for receiving and compressing the stream of tobacco, the transfer and compression; a pair of squeeze bars for compressing the tobacco in a direction perpendicular to the pair of transfer and compression belts, the pair of squeeze bars produced from a material comprising a poly(aryl ether ketone); a tongue for receiving the compressed tobacco, the tongue produced from a material comprising a poly(aryl ether ketone); and a folder for folding a wrapper material around the compressed tobacco so as to form a continuous rod of tobacco, the wrapper material provided from a source of wrapper material, the folder produced from a material comprising a poly(aryl ether ketone).

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a JAK or other kinase inhibitor.

Abstract: An apparatus for the formation of machine-made tobacco rods for use in the production of smoking articles, such as cigars, from tobacco comprising a tacky material. The apparatus includes a pair of transfer and compression belts for receiving and compressing the stream of tobacco, the transfer and compression; a pair of squeeze bars for compressing the tobacco in a direction perpendicular to the pair of transfer and compression belts, the pair of squeeze bars produced from a material comprising a poly(aryl ether ketone); a tongue for receiving the compressed tobacco, the tongue produced from a material comprising a poly(aryl ether ketone); and a folder for folding a wrapper material around the compressed tobacco so as to form a continuous rod of tobacco, the wrapper material provided from a source of wrapper material, the folder produced from a material comprising a poly(aryl ether ketone).

Abstract: A light modifying apparatus is provided, which may comprise a curved outer layer comprising a substrate configured to modify light, wherein the curved outer layer may have an arc of length X. A second curved me be disposed on, or in close proximity to the back surface of the outer layer, and wherein the second curved layer may have an arc of length Y wherein length Y is less than length X, and wherein the second curved layer may comprise a substrate comprising one or more surfaces comprising a lenticular lens configuration. An optional third layer may be provided which may comprise a substrate comprising one or more surfaces comprising a lenticular lens configuration.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a S1P modulator.

Abstract: The method includes transporting tobacco into and through a shaft of a tongue of a compression box, and compressing the tobacco into a tobacco rod as the tobacco is transported through the compression box, the compression box including a first plate, a first portion of the first plate being formed over an upper portion of the shaft, the first portion running along a majority of a longitudinal length of the shaft.

Abstract: The tongue includes a major body, where the major body has a first longitudinal length that runs from a first end to a second end of the major body. The major body includes a first channel defined along a first edge of the major body, and a second channel defined along a second edge of the major body. The first channel and the second channel is hollow and runs substantially along the first longitudinal length from the first end to the second end of the major body. The first channel and the second channel oppose each other and face away from each other. The tongue support assembly and the rod forming apparatus include the tongue. The method aligns the tongue with a lower plate of a compression box.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an IL-12/IL-23 inhibitor.

Abstract: The tongue includes a shaft, the shaft being hollow. The tongue includes an upper plate connected to the shaft. The upper plate includes a first protrusion on a first side of the upper plate, and a second protrusion on the first side of the upper plate. The first protrusion and the second protrusion define a notch. The first protrusion runs along at least part of an upper portion of a longitudinal length of the shaft. The rod forming apparatus includes the tongue. The method installs the tongue on the rod forming apparatus.

Abstract: In various embodiments, the present disclosure relates generally to gaming systems and methods that concurrently display one or more aspects of a primary game and a play of a secondary game within the limited display space available of an electronic gaming machine with a single display device.

Abstract: In various embodiments, the gaming system and method provide The present disclosure relates generally to gaming systems and methods that concurrently display one or more aspects of a primary game and a play of a secondary game within the limited display space available of an electronic gaming machine with a single display device.

Abstract: A bead delivery disk, system and method of delivering flavor beads to a tobacco rod or tow including a bead source, a bead delivery disk in communication with the bead source, including a central disk portion having front and back sides and a first central thickness, an inner annular rim around the central disk portion, the inner annular rim having a second thickness less than said first thickness, a series of pockets spaced around the inner annular rim and multiple vacuum transmission apertures located on one side of the disk, each aperture communicating with at least one of the pockets.