Patents by Inventor David J. Ecker

David J. Ecker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10662485
    Abstract: The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: May 26, 2020
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Publication number: 20180230521
    Abstract: The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
    Type: Application
    Filed: April 13, 2018
    Publication date: August 16, 2018
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Publication number: 20180164280
    Abstract: Provided herein is technology relating to nanopore analysis of nucleic acids and particularly, but not exclusively, to compositions, methods, systems, and kits for analysis of nucleic acids or other assays comprising nucleic acid components.
    Type: Application
    Filed: November 6, 2017
    Publication date: June 14, 2018
    Inventors: David J. Ecker, Stanley T. Motley, James C. Hannis, Lara G. Krieg, Todd P. Michael, David D. Duncan, Shane G. Poplawski, Thomas N. Chiesl
  • Patent number: 9970061
    Abstract: The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: May 15, 2018
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Publication number: 20170275622
    Abstract: Provided herein are compositions and methods for the alteration of neuronal methylation by synthetic piRNAs or by alteration of piRNA function. Such alterations find use in the regulation and control of neural gene expression and concomitant neural functions. Further provided herein are systems and methods for the identification of target sites for regulation by piRNAs.
    Type: Application
    Filed: March 27, 2017
    Publication date: September 28, 2017
    Inventors: David J. Ecker, Todd P. Michael, Lendell L. Cummins, Mark W. Eshoo, Stanley T. Motley, Danny M. Chou
  • Publication number: 20170275687
    Abstract: Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in pH to monitor base addition.
    Type: Application
    Filed: June 5, 2017
    Publication date: September 28, 2017
    Inventors: Jeffrey Huff, Graham Davis, Mark Hayden, David J. Ecker, Dan Wang, Gordon Bruce Collier
  • Patent number: 9752184
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: September 5, 2017
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill K. White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
  • Patent number: 9725771
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: August 8, 2017
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall
  • Patent number: 9670538
    Abstract: Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in pH to monitor base addition. In some embodiments the electrochemical hydrogen ion sensor is a microfabricated mixed metal oxide electrode and in some embodiments the electrochemical hydrogen ion sensor is a membrane electrode. Moreover, in some embodiments the device further comprises a reference electrode. Performing the sequencing reaction involves moving solutions and other fluids (e.g., samples, nucleotide solutions, wash solutions) into and out of the reaction vessel. Thus, in some embodiments, the device further comprises a tube or other transport mechanism or pathway attached to the reaction vessel.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: June 6, 2017
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: Jeffrey Huff, Graham Davis, Mark Hayden, David J. Ecker, Dan Wang, Gordon Bruce Collier
  • Patent number: 9605260
    Abstract: Provided herein are compositions and methods for the alteration of neuronal methylation by synthetic piRNAs or by alteration of piRNA function. Such alterations find use in the regulation and control of neural gene expression and concomitant neural functions. Further provided herein are systems and methods for the identification of target sites for regulation by piRNAs.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 28, 2017
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Todd P. Michael, Lendell L. Cummins, Mark W. Eshoo, Stanley T. Motley, Danny M. Chou
  • Publication number: 20170044630
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Application
    Filed: August 15, 2016
    Publication date: February 16, 2017
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall
  • Publication number: 20160325283
    Abstract: The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.
    Type: Application
    Filed: July 18, 2016
    Publication date: November 10, 2016
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Patent number: 9447462
    Abstract: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: September 20, 2016
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, Thomas A. Hall
  • Patent number: 9416424
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: August 16, 2016
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence Blyn, Ray Ranken, Thomas A. Hall
  • Patent number: 9393564
    Abstract: The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: July 19, 2016
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Publication number: 20160180020
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: December 30, 2014
    Publication date: June 23, 2016
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Publication number: 20160108461
    Abstract: The methods disclosed herein relate to methods and compositions for amplifying nucleic acid sequences, more specifically, from nucleic acid sequences of pathogens by targeted whole genome amplification.
    Type: Application
    Filed: October 5, 2015
    Publication date: April 21, 2016
    Inventors: David J. Ecker, Mark W. Eshoo
  • Publication number: 20150284778
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 8, 2015
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence Blyn, Ray Ranken, Thomas A. Hall
  • Patent number: 9149473
    Abstract: The methods disclosed herein relate to methods and compositions for amplifying nucleic acid sequences, more specifically, from nucleic acid sequences of pathogens by targeted whole genome amplification.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: October 6, 2015
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Mark W. Eshoo
  • Publication number: 20150225780
    Abstract: The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
    Type: Application
    Filed: October 21, 2013
    Publication date: August 13, 2015
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, James C. Hannis