Patents by Inventor David J. Ecker

David J. Ecker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for rapid detection and identification of bioagents
    Patent number: 8017358
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: September 13, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Method for rapid detection and identification of bioagents
    Patent number: 8017322
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: September 13, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil
  • Compositions for use in identification of bacteria
    Patent number: 8013142
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: September 6, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, David J. Ecker, Lawrence Blyn
  • COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF OLIGONUCLEOTIDES
    Publication number: 20110213014
    Abstract: The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
    Type: Application
    Filed: May 13, 2011
    Publication date: September 1, 2011
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Rahul C. Mehta, Gregory E. Hardee, Phillip Dan Cook, David J. Ecker, Yali Jennifer Tsai, Michael V. Templin
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF HERPESVIRUSES
    Publication number: 20110200985
    Abstract: The present invention relates generally to identification of herpesviruses and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 29, 2009
    Publication date: August 18, 2011
    Inventors: Rangarajan Sampath, Rachael Kreft, Lawrence B. Blyn, Feng Li, Thomas A. Hall, David J. Ecker
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF ENTERIC BACTERIAL PATHOGENS
    Publication number: 20110200997
    Abstract: The present invention relates generally to identification of enteric bacterial pathogens, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: May 29, 2009
    Publication date: August 18, 2011
    Applicant: IBIS Biosciences, Inc.
    Inventors: Sherilynn Manalili Wheeler, James C. Hannis, Feng Li, Raymond Ranken, Lawrence B. Blyn, David J. Ecker, Rangarajian Sampath, Steven A. Hofstadler
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF ANTIBIOTIC-RESISTANT BACTERIA
    Publication number: 20110190170
    Abstract: The present invention relates generally to identification of antibiotic-resistant bacteria and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 30, 2009
    Publication date: August 4, 2011
    Inventors: Rangarajan Sampath, David J. Ecker, Robert J. Lovari, Feng Li, Lawrence B. Blyn, Thomas A. Hall
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF FUNGI
    Publication number: 20110189676
    Abstract: The present invention relates generally to identification of fungi pathogens, and provides methods, compositions, systems and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 30, 2009
    Publication date: August 4, 2011
    Inventors: Thomas A. Hall, Mark Frinder, Raymond Ranken, Miriam Reyes, Sherilynn Manalili Wheeler, Lawrence B. Blyn, Rangarajan Sampath, David J. Ecker
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF CLOSTRIDIUM DIFFICILE
    Publication number: 20110183344
    Abstract: The present invention relates generally to identification of strains of Clostridium difficile and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 30, 2009
    Publication date: July 28, 2011
    Inventors: Rangarajan Sampath, Feng Li, David J. Ecker, Robert J. Lovari, Lawrence B. Blyn, Thomas A. Hall
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF STREPTOCOCCUS PNEUMONIAE
    Publication number: 20110183345
    Abstract: The present invention relates generally to the identification of Streptococcus pneumoniae, such as antibiotic resistant Streptococcus pneumoniae, and provides methods, compositions, kits and systems useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 30, 2009
    Publication date: July 28, 2011
    Applicant: Ibis Biosciences, Inc.
    Inventors: Christian Massire, Rachael Kreft, Lawrence B. Blyn, David J. Ecker, Feng Li, Rangarajan Sampath
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF MEMBERS OF THE BACTERIAL CLASS ALPHAPROTEOBACTER
    Publication number: 20110183343
    Abstract: The present invention relates generally to identification of members of the bacterial class Alphaproteobacter and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 30, 2009
    Publication date: July 28, 2011
    Inventors: Rangarajan Sampath, Feng Li, Robert J. Lovari, Lawrence B. Blyn, David J. Ecker
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF FRANCISELLA
    Publication number: 20110177515
    Abstract: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of bacteria which are members of the Francisella genus by amplification of a segment of bacterial nucleic acid followed by molecular mass analysis.
    Type: Application
    Filed: May 29, 2009
    Publication date: July 21, 2011
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: Rangarajan Sampath, David J. Ecker, Mark W. Eshoo, David D. Duncan, Feng Li
  • Secondary Structure Defining Database And Methods For Determining Identity And Geographic Origin Of An Unknown Bioagent Thereby
    Publication number: 20110172925
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 14, 2011
    Applicant: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF STRAINS OF E. COLI O157:H7
    Publication number: 20110166040
    Abstract: The present invention relates generally to strain typing of Escherichia coli O157:H7, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: May 28, 2009
    Publication date: July 7, 2011
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: James C. Hannis, Feng Li, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, David J. Ecker, Mark W. Eshoo
  • Compositions and methods for topical delivery of oligonucleotides
    Patent number: 7964579
    Abstract: The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions include liposomes or penetration enhancers for the delivery of such moieties to dermal and/or epidermal tissue in an animal for investigative, therapeutic or prophylactic purposes.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: June 21, 2011
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rahul C. Mehta, Gregory E. Hardee, Phillip Dan Cook, David J. Ecker, Yali Jennifer Tsai, Michael V. Templin
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF TICK-BORNE PATHOGENS
    Publication number: 20110143358
    Abstract: The present invention relates generally to the field of genetic identification and quantification of tick borne pathogens and provides methods, compositions and kits useful for this purpose when combined with molecular mass or base composition analysis.
    Type: Application
    Filed: May 29, 2009
    Publication date: June 16, 2011
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: Rangarajan Sampath, David J. Ecker, Mark W. Eshoo, Heather E. Matthews, Christopher D. Crowder, Lawrence B. Blyn
  • Compositions for use in identification of bacteria
    Patent number: 7956175
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: June 7, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, David J. Ecker, Lawrence Blyn
  • Antiviral Oligonucleotides Having a Conserved G4 Core Sequence
    Publication number: 20110124715
    Abstract: Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases are also provided.
    Type: Application
    Filed: August 4, 2010
    Publication date: May 26, 2011
    Inventors: Ronnie C. Hanecak, Kevin P. Anderson, C. Frank Bennett, Ming-Yi Chiang, Vickie L. Brown-Driver, David J. Ecker, Timothy Vickers, Jacqueline R. Wyatt
  • COMPOSITIONS AND METHODS FOR IDENTIFICATION OF SUBSPECIES CHARACTERISTICS OF MYCOBACTERIUM TUBERCULOSIS
    Publication number: 20110105531
    Abstract: The present invention provides compositions, kits and methods for rapid genotyping of strains of Mycobacterium tuberculosis by molecular mass and base composition analysis. Drug-resistant strains of Mycobacterium tuberculosis may be identified in human clinical samples and as such, provide for methods of treatment of humans infected with drug resistant strains of Mycobacterium tuberculosis.
    Type: Application
    Filed: June 23, 2008
    Publication date: May 5, 2011
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: Christian Massire, Rangarajan Sampath, Lawrence B. Blyn, David J. Ecker
  • Methods for rapid identification of pathogens in humans and animals
    Patent number: 7781162
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: August 24, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke