Patents by Inventor David J. Evans

David J. Evans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210130533
    Abstract: This invention provides a polymer, which is preferably a polyether polymer. The polymer may be uses in coating compositions. Containers and other articles comprising the polymer and methods of making such containers and other articles are also provided. The invention further provides compositions including the polymer (e.g., powder coatings), which have utility in a variety of coating end uses, including, for example, valve and pipe coatings.
    Type: Application
    Filed: August 16, 2020
    Publication date: May 6, 2021
    Inventors: Jeffrey Niederst, Robert M. O'Brien, Kevin Romagnoli, Mark S. Von Maier, Lan Deng, Richard H. Evans, David J. Santure, Benoit Prouvost
  • Publication number: 20210085458
    Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.
    Type: Application
    Filed: December 3, 2020
    Publication date: March 25, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: Tri D. Tran, Ronaldo C. Cayabyab, David J. Evans, Sean Chow, Christopher Chia, Tamir S. Levi
  • Publication number: 20210030540
    Abstract: Embodiments of the present disclosure provide an introducer device and method for introducing a delivery apparatus into a patient's vasculature. Disclosed methods can include positioning a sleeve of an introducer sheath in a blood vessel of a patient, the sleeve having a lattice layer with a lumen therethrough, inserting a distal end portion of the delivery apparatus and a prosthetic heart valve into the lumen, and advancing the distal end portion of the delivery apparatus through the lumen from the proximal end to the distal end. The method can then include expanding the lumen from a first diameter smaller to a second diameter at least equal to the diameter of the prosthetic heart valve to allow passage of the prosthetic heart valve through the lumen, and returning the lumen of the sleeve to a diameter smaller than the second diameter after advancing the prosthetic heart valve through the lumen.
    Type: Application
    Filed: October 16, 2020
    Publication date: February 4, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Publication number: 20200397574
    Abstract: Embodiments of the present disclosure provide a delivery apparatus for a prosthetic heart valve. Disclosed delivery apparatuses can include a housing, a steerable shaft, a slide nut, and a threaded shaft disposed over the slide nut. The slide nut can have an external threaded surface and an internal surface comprising a slot. The threaded shaft can have an internal threaded surface engaging the external threaded surface of the slide nut. The delivery apparatus can further include an elongated nut guide extending into the slot of the nut to restrain the slide nut against rotation relative to the housing, and a pull wire having a proximal end portion extending into the housing and coupled to the slide nut, and a distal end portion coupled to a distal end portion of the steerable shaft. The threaded shaft can be rotatable relative to the housing to produce axial movement of the slide nut within the threaded shaft.
    Type: Application
    Filed: September 8, 2020
    Publication date: December 24, 2020
    Applicant: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Publication number: 20200390549
    Abstract: Embodiments of the present disclosure provide an introducer device and methods for introducing a medical device into a patient's vasculature. In one embodiment, a method of using an introducer device including a housing, a hemostatic seal mounted within the housing, and a tube extending into the housing and movable longitudinally relative to the hemostatic seal between a proximal position and a distal position, includes moving the tube to the distal position such that the distal end of the tube extends through the hemostatic seal. The method further includes inserting a distal end portion of the medical device through the tube and into the patient's vasculature without contacting the hemostatic seal.
    Type: Application
    Filed: August 26, 2020
    Publication date: December 17, 2020
    Applicant: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Patent number: 10856977
    Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: December 8, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tri D. Tran, Ronaldo C. Cayabyab, David J. Evans, Sean Chow, Christopher Chia, Tamir S. Levi
  • Publication number: 20200375735
    Abstract: Embodiments of the present disclosure provide a delivery apparatus for a prosthetic heart valve. Disclosed steerable catheters can include a handle, a steerable shaft extending from the handle, and a pull wire. The shaft can include a main lumen, an inner polymeric layer surrounding the main lumen, a braided layer surrounding the inner polymeric layer, and an outer polymeric layer surrounding the braided layer, the outer polymeric layer defining a pull wire lumen. The pull wire can extend from the handle and through the pull wire lumen and can have a distal end portion coupled to a distal end portion of the shaft.
    Type: Application
    Filed: August 17, 2020
    Publication date: December 3, 2020
    Applicant: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Publication number: 20200368021
    Abstract: Embodiments of the present disclosure provide a delivery apparatus for a prosthetic heart valve. Disclosed delivery apparatuses can include a handle, a first shaft extending from the handle, a second shaft disposed around the first shaft, and a valve cover. The valve cover can be coupled to a distal end portion of the first shaft and can be configured to house a prosthetic heart valve in a radially compressed state. The valve cover can have an outer diameter greater than an outer diameter of the second shaft, and the first shaft and valve cover can be movable together in an axial direction relative to the second shaft.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Applicant: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Publication number: 20200237504
    Abstract: A valve catheter is advanced through a patient's vasculature while a prosthetic heart valve is attached to flexible extensions along a distal end thereof. The valve catheter is advanced through a tubular sleeve for exposing the prosthetic heart valve and allowing the prosthetic heart valve to self-expand while the extensions remain attached to the prosthetic heart valve. A release mechanism on a handle portion is actuated for releasing the prosthetic heart valve from the extensions, thereby implanting the prosthetic heart in a native heart valve. If the operator is not satisfied with the initial expansion, the prosthetic heart valve may be reoriented before release from the extensions by retracting the prosthetic heart valve back into the tubular sleeve, adjusting the orientation of the prosthetic heart valve and then re-advancing the valve catheter from the tubular sleeve for allowing the prosthetic heart valve to re-self-expand at a more desirable location.
    Type: Application
    Filed: April 15, 2020
    Publication date: July 30, 2020
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Iobbi, David J. Evans, Rajesh A. Khanna
  • Patent number: 10624739
    Abstract: An assembly for treating a native valve in a human heart includes a prosthetic heart valve having an expandable frame and a valvular structure. The assembly also includes a tubular sleeve and a valve catheter disposed within the sleeve. A plurality of metal extension arms are coupled to the valve catheter for holding the prosthetic heart valve. The extension arms are configured to radially expand with the prosthetic heart valve during expansion of the prosthetic heart valve at a treatment site. A plurality of metal rods extend distally from the valve catheter. The rods are axially movable relative to the extension arms. A plurality of release members are provided for releasing the prosthetic heart valve from the extension arms upon movement of the metal rods.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: April 21, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario M. Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
  • Publication number: 20190216819
    Abstract: This invention relates to a solid phase method of synthesising biomolecule-drug-conjugates. In particular, this invention relates to a solid phase method of synthesising antibody-drug-conjugates (ADCs). This invention also relates to intermediate methods of producing immobilised, chemically modified biomolecules, e.g. antibodies. The invention also relates to various uses of capture resins and to biomolecule-drug-conjugates, intermediate products and compositions of the methods of the invention.
    Type: Application
    Filed: January 31, 2019
    Publication date: July 18, 2019
    Inventors: David J. Evans, Colin M. McKee
  • Patent number: 10278815
    Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: May 7, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Publication number: 20190110895
    Abstract: Embodiments of the present disclosure provide an introducer device for introducing a medical device into a patient's vasculature. In one embodiment, the introducer device comprises a housing, a distal sheath adapted to be inserted into a patient's vasculature with the housing positioned outside of the patient's vasculature, a hemostatic seal mounted within the housing, and a tube positioned within the housing and movable longitudinally relative to the hemostatic seal between a proximal position and a distal position. In the proximal position, a distal end of the tube is positioned proximal to the hemostatic seal with the hemostatic seal closed. In the distal position, the distal end of the tube extends through the hemostatic seal and permits the medical device to be inserted through the housing and into the patient's vasculature without contacting the hemostatic seal.
    Type: Application
    Filed: December 11, 2018
    Publication date: April 18, 2019
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Patent number: 10201544
    Abstract: This invention relates to a solid phase method of synthesizing biomolecule-drug conjugates. In particular, this invention relates to a solid phase method of synthesizing antibody-drug conjugates (ADCs). This invention also relates to intermediate methods of producing immobilized, chemically modified biomolecules, e.g. antibodies. The invention also relates to various uses of capture resins and to biomolecule-drug conjugates, intermediate products and compositions prepared by the methods of the invention.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: February 12, 2019
    Assignee: ADC Biotechnology Ltd.
    Inventors: David J. Evans, Colin M. McKee
  • Patent number: 10179048
    Abstract: Embodiments of the present disclosure provide a delivery apparatus for delivering a prosthetic heart valve to a native valve site via the human vasculature without the need for a separate introducer sheath. The delivery apparatus is particularly well-suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a stenotic aortic valve.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: January 15, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Publication number: 20180303608
    Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.
    Type: Application
    Filed: June 25, 2018
    Publication date: October 25, 2018
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Patent number: 10010418
    Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: July 3, 2018
    Assignee: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo Cayabyab, Robert Bowes
  • Publication number: 20180125643
    Abstract: An assembly for treating a native valve in a human heart includes a prosthetic heart valve having an expandable frame and a valvular structure. The assembly also includes a tubular sleeve and a valve catheter disposed within the sleeve. A plurality of metal extension arms are coupled to the valve catheter for holding the prosthetic heart valve. The extension arms are configured to radially expand with the prosthetic heart valve during expansion of the prosthetic heart valve at a treatment site. A plurality of metal rods extend distally from the valve catheter. The rods are axially movable relative to the extension arms. A plurality of release members are provided for releasing the prosthetic heart valve from the extension arms upon movement of the metal rods.
    Type: Application
    Filed: December 6, 2017
    Publication date: May 10, 2018
    Applicant: Edwards Lifesciences Corporation
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario M. Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
  • Publication number: 20180036124
    Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.
    Type: Application
    Filed: October 20, 2017
    Publication date: February 8, 2018
    Applicant: Edwards Lifesciences Corporation
    Inventors: Tri D. Tran, Ronaldo C. Cayabyab, David J. Evans, Sean Chow, Christopher Chia, Tamir S. Levi
  • Publication number: 20170360560
    Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.
    Type: Application
    Filed: August 14, 2017
    Publication date: December 21, 2017
    Applicant: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo Cayabyab, Robert Bowes