Patents by Inventor David J. Evans
David J. Evans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10624739Abstract: An assembly for treating a native valve in a human heart includes a prosthetic heart valve having an expandable frame and a valvular structure. The assembly also includes a tubular sleeve and a valve catheter disposed within the sleeve. A plurality of metal extension arms are coupled to the valve catheter for holding the prosthetic heart valve. The extension arms are configured to radially expand with the prosthetic heart valve during expansion of the prosthetic heart valve at a treatment site. A plurality of metal rods extend distally from the valve catheter. The rods are axially movable relative to the extension arms. A plurality of release members are provided for releasing the prosthetic heart valve from the extension arms upon movement of the metal rods.Type: GrantFiled: December 6, 2017Date of Patent: April 21, 2020Assignee: Edwards Lifesciences CorporationInventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario M. Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
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Publication number: 20190216819Abstract: This invention relates to a solid phase method of synthesising biomolecule-drug-conjugates. In particular, this invention relates to a solid phase method of synthesising antibody-drug-conjugates (ADCs). This invention also relates to intermediate methods of producing immobilised, chemically modified biomolecules, e.g. antibodies. The invention also relates to various uses of capture resins and to biomolecule-drug-conjugates, intermediate products and compositions of the methods of the invention.Type: ApplicationFiled: January 31, 2019Publication date: July 18, 2019Inventors: David J. Evans, Colin M. McKee
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Patent number: 10278815Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.Type: GrantFiled: June 25, 2018Date of Patent: May 7, 2019Assignee: Edwards Lifesciences CorporationInventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
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Publication number: 20190110895Abstract: Embodiments of the present disclosure provide an introducer device for introducing a medical device into a patient's vasculature. In one embodiment, the introducer device comprises a housing, a distal sheath adapted to be inserted into a patient's vasculature with the housing positioned outside of the patient's vasculature, a hemostatic seal mounted within the housing, and a tube positioned within the housing and movable longitudinally relative to the hemostatic seal between a proximal position and a distal position. In the proximal position, a distal end of the tube is positioned proximal to the hemostatic seal with the hemostatic seal closed. In the distal position, the distal end of the tube extends through the hemostatic seal and permits the medical device to be inserted through the housing and into the patient's vasculature without contacting the hemostatic seal.Type: ApplicationFiled: December 11, 2018Publication date: April 18, 2019Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
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Patent number: 10201544Abstract: This invention relates to a solid phase method of synthesizing biomolecule-drug conjugates. In particular, this invention relates to a solid phase method of synthesizing antibody-drug conjugates (ADCs). This invention also relates to intermediate methods of producing immobilized, chemically modified biomolecules, e.g. antibodies. The invention also relates to various uses of capture resins and to biomolecule-drug conjugates, intermediate products and compositions prepared by the methods of the invention.Type: GrantFiled: April 25, 2014Date of Patent: February 12, 2019Assignee: ADC Biotechnology Ltd.Inventors: David J. Evans, Colin M. McKee
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Patent number: 10179048Abstract: Embodiments of the present disclosure provide a delivery apparatus for delivering a prosthetic heart valve to a native valve site via the human vasculature without the need for a separate introducer sheath. The delivery apparatus is particularly well-suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a stenotic aortic valve.Type: GrantFiled: February 11, 2016Date of Patent: January 15, 2019Assignee: Edwards Lifesciences CorporationInventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
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Publication number: 20180303608Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.Type: ApplicationFiled: June 25, 2018Publication date: October 25, 2018Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
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Patent number: 10010418Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.Type: GrantFiled: August 14, 2017Date of Patent: July 3, 2018Assignee: Edwards Lifesciences CorporationInventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo Cayabyab, Robert Bowes
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Publication number: 20180125643Abstract: An assembly for treating a native valve in a human heart includes a prosthetic heart valve having an expandable frame and a valvular structure. The assembly also includes a tubular sleeve and a valve catheter disposed within the sleeve. A plurality of metal extension arms are coupled to the valve catheter for holding the prosthetic heart valve. The extension arms are configured to radially expand with the prosthetic heart valve during expansion of the prosthetic heart valve at a treatment site. A plurality of metal rods extend distally from the valve catheter. The rods are axially movable relative to the extension arms. A plurality of release members are provided for releasing the prosthetic heart valve from the extension arms upon movement of the metal rods.Type: ApplicationFiled: December 6, 2017Publication date: May 10, 2018Applicant: Edwards Lifesciences CorporationInventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario M. Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
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Publication number: 20180036124Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.Type: ApplicationFiled: October 20, 2017Publication date: February 8, 2018Applicant: Edwards Lifesciences CorporationInventors: Tri D. Tran, Ronaldo C. Cayabyab, David J. Evans, Sean Chow, Christopher Chia, Tamir S. Levi
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Publication number: 20170360560Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.Type: ApplicationFiled: August 14, 2017Publication date: December 21, 2017Applicant: Edwards Lifesciences CorporationInventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo Cayabyab, Robert Bowes
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Patent number: 9839514Abstract: An assembly for treating a native heart valve can include a prosthetic valve and a delivery apparatus. The prosthetic valve can include an expandable frame, a valve structure, a first end with apertures formed therein, and a second end. The delivery apparatus can include a valve catheter, flexible extension arms, slidable wires, and release members. First ends of the arms can be coupled to a cylindrical coupling element, second ends of the arms can be releasably coupled to the prosthetic valve, and the coupling element can be connected to the distal end of the valve catheter. The slidable wires can extend distally from the distal end of the valve catheter. The release members can be coupled to the distal end of the valve catheter and can extend through a respective aperture of the prosthetic valve, thereby forming a releasable connection between the prosthetic valve and the slidable wires.Type: GrantFiled: November 9, 2016Date of Patent: December 12, 2017Assignee: Edwards Lifesciences CorporationInventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
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Patent number: 9795477Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.Type: GrantFiled: April 22, 2016Date of Patent: October 24, 2017Assignee: Edwards Lifesciences CorporationInventors: Tri D. Tran, Ronaldo C. Cayabyab, David J. Evans, Sean Chow, Christopher Chia
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Publication number: 20170056161Abstract: An assembly for treating a native heart valve can include a prosthetic valve and a delivery apparatus. The prosthetic valve can include an expandable frame, a valve structure, a first end with apertures formed therein, and a second end. The delivery apparatus can include a valve catheter, flexible extension arms, slidable wires, and release members. First ends of the arms can be coupled to a cylindrical coupling element, second ends of the arms can be releasably coupled to the prosthetic valve, and the coupling element can be connected to the distal end of the valve catheter. The slidable wires can extend distally from the distal end of the valve catheter. The release members can be coupled to the distal end of the valve catheter and can extend through a respective aperture of the prosthetic valve, thereby forming a releasable connection between the prosthetic valve and the slidable wires.Type: ApplicationFiled: November 9, 2016Publication date: March 2, 2017Applicant: Edwards Lifesciences CorporationInventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
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Patent number: 9545461Abstract: The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.Type: GrantFiled: October 21, 2015Date of Patent: January 17, 2017Assignee: The Regents of the University of CaliforniaInventors: Suzanne M. J. Fleiszig, David J. Evans, Kwai Ping Tam, James J. Mun
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Patent number: 9539092Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve. The prosthetic valve is preferably coupled to the valve catheter by a plurality of flexible extension arms which allow the prosthetic valve to be collapsed after initial deployment such that the prosthetic valve may be repositioned if necessary.Type: GrantFiled: December 4, 2014Date of Patent: January 10, 2017Assignee: Edwards Lifesciences CorporationInventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
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Publication number: 20160235532Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.Type: ApplicationFiled: April 22, 2016Publication date: August 18, 2016Inventors: Tri D. Tran, Ronaldo C. Cayabyab, David J. Evans, Sean Chow, Christopher Chia
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Publication number: 20160158009Abstract: Embodiments of the present disclosure provide a delivery apparatus for delivering a prosthetic heart valve to a native valve site via the human vasculature without the need for a separate introducer sheath. The delivery apparatus is particularly well-suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a stenotic aortic valve.Type: ApplicationFiled: February 11, 2016Publication date: June 9, 2016Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
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Publication number: 20160151534Abstract: The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.Type: ApplicationFiled: October 21, 2015Publication date: June 2, 2016Inventors: Suzanne M.J. Fleiszig, David J. Evans, Kwai Ping Tam, James J. Mun
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Patent number: 9339384Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.Type: GrantFiled: July 26, 2012Date of Patent: May 17, 2016Assignee: Edwards Lifesciences CorporationInventors: Tri D. Tran, Ronaldo Cayabyab, David J. Evans, Sean Chow, Christopher Chia