Patents by Inventor David J. Evans

David J. Evans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10010418
    Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: July 3, 2018
    Assignee: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo Cayabyab, Robert Bowes
  • Publication number: 20180125643
    Abstract: An assembly for treating a native valve in a human heart includes a prosthetic heart valve having an expandable frame and a valvular structure. The assembly also includes a tubular sleeve and a valve catheter disposed within the sleeve. A plurality of metal extension arms are coupled to the valve catheter for holding the prosthetic heart valve. The extension arms are configured to radially expand with the prosthetic heart valve during expansion of the prosthetic heart valve at a treatment site. A plurality of metal rods extend distally from the valve catheter. The rods are axially movable relative to the extension arms. A plurality of release members are provided for releasing the prosthetic heart valve from the extension arms upon movement of the metal rods.
    Type: Application
    Filed: December 6, 2017
    Publication date: May 10, 2018
    Applicant: Edwards Lifesciences Corporation
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario M. Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
  • Publication number: 20180036124
    Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.
    Type: Application
    Filed: October 20, 2017
    Publication date: February 8, 2018
    Applicant: Edwards Lifesciences Corporation
    Inventors: Tri D. Tran, Ronaldo C. Cayabyab, David J. Evans, Sean Chow, Christopher Chia, Tamir S. Levi
  • Publication number: 20170360560
    Abstract: An assembly includes a prosthetic heart valve and a delivery apparatus for implanting the prosthetic heart valve within the native aortic valve of a patient. The prosthetic heart valve has a radially compressible and expandable metallic stent and a flexible valvular structure mounted within the stent. The delivery apparatus has a handle, a first shaft having a proximal end portion and a distal end portion, a second shaft extending co-axially through the first shaft and having a proximal end portion and a distal end portion, the proximal end portions of the first and second shafts extending distally from the handle, a valve cover coupled to the distal end portion of the first shaft, and a nose piece coupled to the distal end portion of the second shaft.
    Type: Application
    Filed: August 14, 2017
    Publication date: December 21, 2017
    Applicant: Edwards Lifesciences Corporation
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo Cayabyab, Robert Bowes
  • Patent number: 9839514
    Abstract: An assembly for treating a native heart valve can include a prosthetic valve and a delivery apparatus. The prosthetic valve can include an expandable frame, a valve structure, a first end with apertures formed therein, and a second end. The delivery apparatus can include a valve catheter, flexible extension arms, slidable wires, and release members. First ends of the arms can be coupled to a cylindrical coupling element, second ends of the arms can be releasably coupled to the prosthetic valve, and the coupling element can be connected to the distal end of the valve catheter. The slidable wires can extend distally from the distal end of the valve catheter. The release members can be coupled to the distal end of the valve catheter and can extend through a respective aperture of the prosthetic valve, thereby forming a releasable connection between the prosthetic valve and the slidable wires.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: December 12, 2017
    Assignee: Edwards Lifesciences Corporation
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
  • Patent number: 9795477
    Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: October 24, 2017
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tri D. Tran, Ronaldo C. Cayabyab, David J. Evans, Sean Chow, Christopher Chia
  • Publication number: 20170056161
    Abstract: An assembly for treating a native heart valve can include a prosthetic valve and a delivery apparatus. The prosthetic valve can include an expandable frame, a valve structure, a first end with apertures formed therein, and a second end. The delivery apparatus can include a valve catheter, flexible extension arms, slidable wires, and release members. First ends of the arms can be coupled to a cylindrical coupling element, second ends of the arms can be releasably coupled to the prosthetic valve, and the coupling element can be connected to the distal end of the valve catheter. The slidable wires can extend distally from the distal end of the valve catheter. The release members can be coupled to the distal end of the valve catheter and can extend through a respective aperture of the prosthetic valve, thereby forming a releasable connection between the prosthetic valve and the slidable wires.
    Type: Application
    Filed: November 9, 2016
    Publication date: March 2, 2017
    Applicant: Edwards Lifesciences Corporation
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
  • Patent number: 9545461
    Abstract: The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: January 17, 2017
    Assignee: The Regents of the University of California
    Inventors: Suzanne M. J. Fleiszig, David J. Evans, Kwai Ping Tam, James J. Mun
  • Patent number: 9539092
    Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve. The prosthetic valve is preferably coupled to the valve catheter by a plurality of flexible extension arms which allow the prosthetic valve to be collapsed after initial deployment such that the prosthetic valve may be repositioned if necessary.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: January 10, 2017
    Assignee: Edwards Lifesciences Corporation
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
  • Publication number: 20160235532
    Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.
    Type: Application
    Filed: April 22, 2016
    Publication date: August 18, 2016
    Inventors: Tri D. Tran, Ronaldo C. Cayabyab, David J. Evans, Sean Chow, Christopher Chia
  • Publication number: 20160158009
    Abstract: Embodiments of the present disclosure provide a delivery apparatus for delivering a prosthetic heart valve to a native valve site via the human vasculature without the need for a separate introducer sheath. The delivery apparatus is particularly well-suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a stenotic aortic valve.
    Type: Application
    Filed: February 11, 2016
    Publication date: June 9, 2016
    Inventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
  • Publication number: 20160151534
    Abstract: The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.
    Type: Application
    Filed: October 21, 2015
    Publication date: June 2, 2016
    Inventors: Suzanne M.J. Fleiszig, David J. Evans, Kwai Ping Tam, James J. Mun
  • Patent number: 9339384
    Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: May 17, 2016
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tri D. Tran, Ronaldo Cayabyab, David J. Evans, Sean Chow, Christopher Chia
  • Publication number: 20160067352
    Abstract: This invention relates to a solid phase method of synthesizing biomolecule-drug conjugates. In particular, this invention relates to a solid phase method of synthesizing antibody-drug conjugates (ADCs). This invention also relates to intermediate methods of producing immobilized, chemically modified biomolecules, e.g. antibodies. The invention also relates to various uses of capture resins and to biomolecule-drug conjugates, intermediate products and compositions prepared by the methods of the invention.
    Type: Application
    Filed: April 25, 2014
    Publication date: March 10, 2016
    Inventors: David J. Evans, Colin M. McKee
  • Publication number: 20160032252
    Abstract: The invention is in the field of virology and relates to the deformed wing virus (DWV). A new strain of deformed wing virus (DWV) has been identified that is predominant in bees infested with Varroa mites. This particular strain of DWV can be used in diagnostics to identify at risk colonies. Also, inhibitors of the particular strain may be used in the treatment and/or prevention of DWV.
    Type: Application
    Filed: April 15, 2014
    Publication date: February 4, 2016
    Applicant: THE UNIVERSITY OF WARWICK
    Inventors: David J. EVANS, Eugene RYABOV
  • Patent number: 9187541
    Abstract: The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: November 17, 2015
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Suzanne M. J. Fleiszig, David J. Evans, Kwai Ping Tam, James J. Mun
  • Publication number: 20150182334
    Abstract: A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve. The prosthetic valve is preferably coupled to the valve catheter by a plurality of flexible extension arms which allow the prosthetic valve to be collapsed after initial deployment such that the prosthetic valve may be repositioned if necessary.
    Type: Application
    Filed: December 4, 2014
    Publication date: July 2, 2015
    Inventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
  • Publication number: 20140267525
    Abstract: An embodiment of an applicator wheel, which applies ink to embossed designs on gutters. This is accomplished during manufacturing process of gutter as gutters exit any gutter machine. The embodiment attaches to any gutter machine, and by a simple process applies ink or paint to any design that is raised/embossed. Ink is held in a well, which distributes through a roller to a transfer roller to applicator wheel pad. Two offset rims keep the pad at correct distance from un-embossed portion of gutter and applicator wheel pad paints only the embossed portion of a design. (FIG. 10). Between flexibility of pad and this offset rim distance, ink is applied only to raised/embossed portion of any design by application wheel roller, rolling along the gutter as it exits gutter machine. Another embodiment applies a design directly onto un-embossed gutters. Again, using the applicator wheel, except this embodiment uses a different applicator wheel pad with a design on the pad. (FIG. 11).
    Type: Application
    Filed: March 12, 2013
    Publication date: September 18, 2014
    Inventor: David J. Evans
  • Publication number: 20140221460
    Abstract: The invention relates to a method for identifying compounds that act as modulators of hepatitis C (HCV) translation and/or replication, and to compounds identified by this method, and their uses in medicine. The invention also relates to an RNA useful for identifying modulators of HCV translation and/or replication. The invention further relates to a method for producing a replication-competent HCV virus.
    Type: Application
    Filed: August 17, 2012
    Publication date: August 7, 2014
    Applicants: UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH, THE UNIVERSITY OF WARWICK
    Inventors: David J. Evans, Peter Simmonds
  • Publication number: 20140221273
    Abstract: The present disclosure provides antimicrobial peptides, and compositions comprising same. The present disclosure further provides methods of inhibiting microbial growth.
    Type: Application
    Filed: April 16, 2012
    Publication date: August 7, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Suzanne M.J. Fleiszig, David J. Evans, Kwai Ping Tam, James J. Mun