Abstract: The present invention describes recombinant antibody toxin fusion proteins which selectively kill cells bearing appropriate antigens or receptors.

Abstract: This invention relates to the production and use of recombinant Pseudomonas-derived toxins modified to increase their toxicity and potency in therapy. More particularly, the invention relates to certain deletions in domain II of the amino acid sequence of Pseudomonas exotoxin the domain which relates to the toxin's natural proteolytic processing.

Abstract: This invention relates to the production and use of recombinant Pseudomonas-derived toxins modified to increase their toxicity and potency in therapy. More particularly, the invention relates to certain deletions in domain II of the amino acid sequence of Pseudomonas exotoxin the domain which relates to the toxin's natural proteolytic processing.

Abstract: This invention relates to the production and use of recombinant Pseudomonas-derived toxins modified to increase their toxicity and potency in therapy. More particularly, the invention relates to certain deletions in domain II of the amino acid sequence of Pseudomonas exotoxin the domain which relates to the toxin's natural proteolytic processing.

Abstract: A retainer ring for wheel cover assemblies for heavy vehicle wheel rims which mount on lug bolts and are held in place by lug nuts including a universal retainer ring which has a multiplicity of adaptor openings to engage a variety of lug bolt and nut patterns and without removal of lug nuts and is secured in place by cam locks.

Abstract: A vehicle wheel lug nut cover comprises a dome shaped tube having an open end that is larger than the lug nut and a closed end with an internal jam nut that is threaded to the end of the lug bolt extending from the lug nut. Lug nut covers may be used to secure a wheel cover to the wheel of the vehicle without removing a lug nut.

Abstract: Proteins that are impermeable and foreign to the eukaryotic cells can now be delivered across cellular membranes into the cytosol of target cells by making a chimeric protein having specific attributes. A method of making such chimeric proteins is disclosed. As an example, a chimeric protein PE-Bar with dual enzymatic activity has been made. The chimeric proteins can be used for cytotoxic, diagnostic or therapeutic purposes, such as for compensating the deficiency or defect of an enzyme or a protein which may be causative of a disease or an abnormality.

Abstract: Apparatus for firmly and quickly mounting an ornamental wheel cover on a bus or truck wheel having handholds and exposed lug nuts by applying a mounting ring that overlies the wheel and has a portion that fits through at least two handholds and can be rotated in a bayonet-type connection to grasp the wheel. A wheel cover with lug nut clearance holes then may be firmly secured with a quarter-turn fastener to the mounting ring which is locked against rotation by the wheel cover hole engagement with the lug nuts.

Abstract: A combination of hot melt and water-based adhesives (solution resin or latex) is particularly advantageous for bonding fibers together to form a layer and for bonding that layer to an adjoining layer. The water-based adhesive, which need not be crosslinkable, provides fiber-to-fiber bonding through the layer of fibers, while the hot melt adhesive bonds the layer of fibers to the adjoining layer. In preferred embodiments, the layer of fibers is moisture absorbent and formed of wood pulp, cotton, rayon, or cellulose triacetate fibers (possibly with the addition of a small amount of thermoplastic fibers to increase bulk); the fibers can be reprocessed fibers of irregular lengths; the water-based adhesive is a latex, non-crosslinkable adhesive; the adjoining layer is permeable to moisture and made of a nonwoven polyolefin, rayon, polyester, or blend thereof; a moisture-barrier layer (e.g.

Abstract: A wheel cover for a vehicle utilizing a mounting member including a first surface and opposite second surface. The mounting member also includes a multiplicity of opening of two types. The first type of openings fits over an existing lug bolt and nut of the vehicle wheel, while the second type of smaller opening merely fits over the lug bolt. Thus, removal of only certain nuts is required to hold the mounting member to a vehicle wheel. A multiplicity of resilient projections at least partially surround the second group of openings. The resilient projections permit the normal seating of a lug nut with a lug bolt while employing the ramped portion of the lug nut to hold the mounting member and other wheel accessories to the vehicle wheel.

Abstract: Apparatus for attaching an ornamental wheel cover to a vehicle having an extending cylindrical wheel hub. A ring having several attached legs or claws is secured to the hub by overlying the legs on the hub and clamping them in place. In one embodiment the wheel cover is removably attached to the ring with an open circular spring having a plurality of outwardly extending points that engage aligned slits in the ring and a central cup in the wheel cover. In a second embodiment, outwardly bent tabs with threaded holes on the ring are aligned with screw holes in the face of the wheel cover so that ring and wheel cover are interconnected by screws.

Abstract: Immunotoxins comprising a cytotoxic moiety and monoclonal antibodies which bind to human ovarian cancer tissue having at least one of the following capabilities are claimed: cytotoxic ID.sub.50 of 10 nM or less against human ovarian cancer cells, retardation of human ovarian cancer tumor growth in mammals or extension of survival of a mammal carrying a human ovarian cancer tumor. Antigens to which the monoclonal antibody of the immunotoxin bind are identified and characterize the immunotoxins. Methods of killing human ovarian cancer cells, retarding the growth of human ovarian cancer tumors in mammals or extending the survival of mammals carrying human ovarian cancer tumors are claimed.

Abstract: Monoclonal antibodies are produced which specifically bind to human ovarian cancer cells. These antibodies are conjugated to Pseudomonas exotoxin in order to produce an immunotoxin suitable for the chemotherapeutic treatment of human ovarian cancer.

Abstract: A method of modifying Pseudomonas exotoxin (PE) with methyl-4-mercaptobutyrimidate is disclosed so that after conjugating the exotoxin to a monoclonal antibody (ab) such as the antibody to the transferrin receptor, the PE-ab conjugate becomes a highly potent immunotoxin suitable for use against human tumor cells. This same method has been used to conjugate PE to epidermal growth factor (EGF) to create a highly potent growth factor-toxin conjugate for use against cells having large numbers of EGF receptors. Also disclosed are the immunotoxin conjugates for Pseudomonas exotoxin coupled to anti-TFR (antibody to the transferrin receptor) and anti-TAC (antibody to the human T-cell growth factor receptor) and to EGF.