Patents by Inventor David J. Mooney

David J. Mooney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN SITU ANTIGEN-GENERATING CANCER VACCINE
    Publication number: 20170182138
    Abstract: The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
    Type: Application
    Filed: November 7, 2016
    Publication date: June 29, 2017
    Inventors: Jaeyun Kim, David J. Mooney, Weiwei Aileen Li, Praveen Arany, Or Gadish
  • INTERPENETRATING NETWORK HYDROGELS WITH INDEPENDENTLY TUNABLE STIFFNESS
    Publication number: 20170182209
    Abstract: Interpenetrating network hydrogels with independently tunable stiffness enhance tissue regeneration and wound healing.
    Type: Application
    Filed: June 12, 2015
    Publication date: June 29, 2017
    Inventors: Cristiana Branco da Cunha, Ovijit Chaudhuri, David J. Mooney
  • Injectable cryogel vaccine devices and methods of use thereof
    Patent number: 9675561
    Abstract: The invention provides polymer compositions for cell and drug delivery.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: June 13, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Sidi A. Bencherif, Roger Warren Sands, Sandeep T. Koshy, David J. Mooney
  • REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
    Publication number: 20170119892
    Abstract: The present invention provides refillable drug delivery devices. The invention is based in part on the development of systemically administered drug payloads that home to and refill resident, e.g., previously administered/implanted, drug delivery systems, e.g., hydrogel drug delivery systems. In one aspect, the drug delivery depots of the invention are systemically administered, e.g., enterally administered or parenterally administered. The invention provides a method of nanotherapeutic drug delivery, e.g., a DNA nanotechnology-based approach for blood-based drug refilling of intra-tumor drug depots.
    Type: Application
    Filed: April 6, 2015
    Publication date: May 4, 2017
    Inventors: Yevgeny Brudno, Cathal J. Kearney, Eduardo Silva, Michael Aizenberg, Brian Kwee, Rajiv Desai, Neel S. Joshi, David J. Mooney
  • Enhancement of skeletal muscle stem cell engraftment by dual delivery of VEGF and IGF-1
    Patent number: 9610328
    Abstract: An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: April 4, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: David J. Mooney, Cristina Borselli, Herman Vandenburgh, Dimitry Shvartsman, Hannah Storrie, Jeff Lichtman
  • Materials presenting notch signaling molecules to control cell behavior
    Patent number: 9603894
    Abstract: The invention provides a solution to the problem of delivering molecules in a physiologically relevant manner to direct cell fate. For example, a Notch ligand molecule is presented in a microenvironment that mimics the environment encountered in vivo. Accordingly, the invention features a cell delivery vehicle comprising a biocompatible hydrogel or polymer and a composition that binds to a Notch receptor and methods of directing cell fate, e.g., stem cell differentiation, using such compositions.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: March 28, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Lan Cao, Kamal H. Bouhadir, David J. Mooney
  • Combination Vaccine Devices and Methods of Killing Cancer Cells
    Publication number: 20170042995
    Abstract: The present invention comprises compositions, methods, and devices for enhancing an endogenous immune response against a cancer. Devices and methods provide therapeutic immunity to subjects against cancer.
    Type: Application
    Filed: April 30, 2015
    Publication date: February 16, 2017
    Inventors: Omar Abdel-Rahman Ali, David J. Mooney, Glenn Dranoff
  • Mineralization and Biological Modification of Biomaterial Surfaces
    Publication number: 20170035941
    Abstract: Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
    Type: Application
    Filed: October 25, 2016
    Publication date: February 9, 2017
    Inventors: William L. Murphy, Martin C. Peters, David J. Mooney
  • Controlled release of growth factors and signaling molecules for promoting angiogenesis
    Patent number: 9539309
    Abstract: The present invention comprises compositions, methods, and devices for delivering angiogenic factors and signaling molecules to a target tissue, and controlling the release of these factors and signaling molecules to spatially and temporally restrict their release and dissemination, for the purpose of promoting angiogenesis in target tissues wherein increased blood supply is needed.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: January 10, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Lan Cao, David J. Mooney
  • INTERPENETRATING NETWORKS WITH COVALENT AND IONIC CROSSLINKS
    Publication number: 20160354520
    Abstract: The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 8, 2016
    Inventors: Jeong-Yun Sun, Xuanhe Zhao, Widusha R.K. Illeperuma, Kyu H. Oh, Joost J. Vlassak, Zhigang Suo, Jianyu Li, David J. Mooney
  • BIOMIMETIC ACTUATION DEVICE AND SYSTEM, AND METHODS FOR CONTROLLING A BIOMIMETIC ACTUATION DEVICE AND SYSTEM
    Publication number: 20160346449
    Abstract: A biomimetic actuation device includes a flexible substrate, conformable for disposition about an object, defining an apex and a base, bearing at least one soft actuator configured to change state from a first state to a second state upon introduction of a pressurized fluid to an internal volume of the at least one soft actuator.
    Type: Application
    Filed: October 6, 2014
    Publication date: December 1, 2016
    Inventors: Ellen T. Roche, Steven Obiajulu, Conor J. Walsh, David J. Mooney, Frank A. Pigula
  • In situ antigen-generating cancer vaccine
    Patent number: 9486512
    Abstract: The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: November 8, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Jaeyun Kim, David J. Mooney, Weiwei Aileen Li, Praveen Arany, Or Gadish
  • Programming of Cells for Tolerogenic Therapies
    Publication number: 20160317630
    Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
    Type: Application
    Filed: May 5, 2016
    Publication date: November 3, 2016
    Inventors: Roger Warren Sands, Eduardo Alexandre Barros E Silva, Toshihisa Kawai, David J. Mooney
  • Mineralization and biological modification of biomaterial surfaces
    Patent number: 9480773
    Abstract: Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: November 1, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: William L. Murphy, Martin C. Peters, David J. Mooney
  • Controlled Delivery of TLR Agonists in Structural Polymeric Devices
    Publication number: 20160296611
    Abstract: The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents.
    Type: Application
    Filed: April 21, 2016
    Publication date: October 13, 2016
    Inventors: Omar Abdel-Rahman Ali, Glenn Dranoff, David J. Mooney
  • Scaffolds For Cell Transplantation
    Publication number: 20160279219
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: April 21, 2016
    Publication date: September 29, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds For Cell Transplantation
    Publication number: 20160279220
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: April 21, 2016
    Publication date: September 29, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • MICROPARTICLES, METHODS FOR THEIR PREPARATION AND USE
    Publication number: 20160279068
    Abstract: The invention relates to microparticles comprising a crosslinked gel and methods for making and using same.
    Type: Application
    Filed: November 4, 2014
    Publication date: September 29, 2016
    Inventors: Stefanie Utech, Radivoje Prodanovic, Esther Amstad, Raluca Ostafe, David A. Weitz, Angelo S. Mao, David J. Mooney, Connie Chang Wilking, Wang Huanan
  • SCAFFOLDS FOR CELL TRANSPLANTATION
    Publication number: 20160271298
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: March 30, 2016
    Publication date: September 22, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds for cell transplantation
    Patent number: 9446107
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: September 20, 2016
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul