Patents by Inventor David J. Mooney

David J. Mooney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Continuous Cell Programming Devices
    Publication number: 20160228543
    Abstract: The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
    Type: Application
    Filed: April 21, 2016
    Publication date: August 11, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Glenn Dranoff
  • CONTINUOUS CELL PROGRAMMING DEVICES
    Publication number: 20160220667
    Abstract: The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
    Type: Application
    Filed: April 21, 2016
    Publication date: August 4, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Glenn Dranoff
  • Continuous Cell Programming Devices
    Publication number: 20160220668
    Abstract: The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.
    Type: Application
    Filed: April 21, 2016
    Publication date: August 4, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Glenn Dranoff
  • REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
    Publication number: 20160220686
    Abstract: The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.
    Type: Application
    Filed: April 12, 2016
    Publication date: August 4, 2016
    Inventors: Yevgeny Brudno, Cathal J. Kearney, Eduardo Silva, Michael Aizenberg, Brian Kwee, Rajiv Desai, Neel S. Joshi, David J. Mooney
  • Interpenetrating networks with covalent and Ionic Crosslinks
    Patent number: 9387276
    Abstract: The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: July 12, 2016
    Assignees: President and Fellows of Harvard College, Seoul National University Industry Foundation
    Inventors: Jeong-Yun Sun, Xuanhe Zhao, Widusha R. K. Illeperuma, Kyu Hwan Oh, Joost J. Vlassak, Zhigang Suo, Jianyu Li, David J. Mooney
  • Programming of cells for tolerogenic therapies
    Patent number: 9381235
    Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: July 5, 2016
    Assignees: President and Fellows of Harvard College, Forsyth Dental Infirmary for Children
    Inventors: Roger Warren Sands, Eduardo Alexandre Barros e Silva, Toshihisa Kawai, David J. Mooney
  • Controlled delivery of TLR agonists in structural polymeric devices
    Patent number: 9370558
    Abstract: The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: June 21, 2016
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Omar Abdel-Rahman Ali, Glenn Dranoff, David J. Mooney
  • REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
    Publication number: 20160114046
    Abstract: The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.
    Type: Application
    Filed: October 8, 2015
    Publication date: April 28, 2016
    Inventors: Yevgeny Brudno, Cathal J. Kearney, Eduardo Silva, Michael Aizenberg, Brian Kwee, Rajiv Desai, Neel S. Joshi, David J. Mooney
  • Harnessing cell dynamics to engineer materials
    Patent number: 9297005
    Abstract: The invention features synthetic materials and methods for inducing cell behavior. Matrix materials induce cell differentiation and cell manipulation based on mechanical and physical characteristics of the materials rather than chemical characteristics.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: March 29, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Nathaniel D. Huebsch, David J. Mooney
  • PREFABRICATED ALGINATE-DRUG BANDAGES
    Publication number: 20160058903
    Abstract: The invention provides a solution to the drawbacks associated with conventional alginate dressings. This invention features improved alginate dressings or bandages as well as a fabrication process that results in an alginate sheet that is preloaded with drug, can be stored in a freeze-dried state, and is compliant and ready to use at the time of administration.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 3, 2016
    Inventors: Cathal J. Kearney, Uyanga Tsedev, David J. Mooney, Aristidis Veves, Thomas Michael Braschler, Sidi A. Bencherif
  • Scaffolds For Cell Transplantation
    Publication number: 20150366956
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 24, 2015
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • VISCOELASTIC HYDROGELS WITH FAST STRESS RELAXATION
    Publication number: 20150359928
    Abstract: Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration.
    Type: Application
    Filed: June 12, 2015
    Publication date: December 17, 2015
    Inventors: Luo Gu, Ovijit Chaudhuri, Nathaniel D. Huebsch, David J. Mooney, Max Carlton Darnell, Simon Young
  • POROUS ELECTROLYTIC POLYMER CRYOGELS FOR ENHANCED ELECTRICAL COLLAPSIBILITY
    Publication number: 20150299415
    Abstract: The invention provides cryogels whose porosity, pore size, pore connectivity, swelling agent concentration, and/or specific volume undergoes a change from a first value to a second value in response to an electrical stimulus. The cryogels have interconnected macropores which greatly enhance their ability to rapidly undergo volumetric collapse when subjected to moderate electric fields. The cryogels of the invention can be easily integrated into arrays capable of rapid configurational and chromatic optical modulations, and when loaded with drugs, are able to coordinate the delivery profile of multiple drugs. The cryogel can be prepared by polymerizing an aqueous solution of charged monomers and cross-linker monomers at a temperature below the freezing temperature of the solvent.
    Type: Application
    Filed: August 2, 2013
    Publication date: October 22, 2015
    Inventors: Stephen Michael KENNEDY, Sidi Ahmed BENCHERIF, David J. MOONEY
  • Controlled Release Of Growth Factors And Signaling Molecules For Promoting Angiogenesis
    Publication number: 20150283210
    Abstract: The present invention comprises compositions, methods, and devices for delivering angiogenic factors and signaling molecules to a target tissue, and controlling the release of these factors and signaling molecules to spatially and temporally restrict their release and dissemination, for the purpose of promoting angiogenesis in target tissues wherein increased blood supply is needed.
    Type: Application
    Filed: April 6, 2015
    Publication date: October 8, 2015
    Inventors: Lan Cao, David J. Mooney
  • Mineralization and Biological Modification of Biomaterial Surfaces
    Publication number: 20150258242
    Abstract: Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
    Type: Application
    Filed: May 28, 2015
    Publication date: September 17, 2015
    Inventors: William L. Murphy, Martin C. Peters, David J. Mooney
  • Scaffolds for cell transplantation
    Patent number: 9132210
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: September 15, 2015
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
  • Active scaffolds for on-demand drug and cell delivery
    Patent number: 9089512
    Abstract: The invention provides a composition whose porosity, pore size, pore connectivity, swelling agent concentration, and/or specific volume undergoes a change from a first value to a second value in response to an electromagnetic signal, the composition having a matrix material in which is distributed a magnetic material.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: July 28, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: David J. Mooney, Xuanhe Zhao
  • Mineralization and biological modification of biomaterial surfaces
    Patent number: 9072813
    Abstract: Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: July 7, 2015
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: William L. Murphy, Martin C. Peters, David J. Mooney, David H. Kohn
  • Controlled release of growth factors and signaling molecules for promoting angiogenesis
    Patent number: 9012399
    Abstract: The present invention comprises compositions, methods, and devices for delivering angiogenic factors and signaling molecules to a target tissue, and controlling the release of these factors and signaling molecules to spatially and temporally restrict their release and dissemination, for the purpose of promoting angiogenesis in target tissues.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: April 21, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Lan Cao, David J. Mooney
  • Mesoporous Silica Compositions for Modulating Immune Responses
    Publication number: 20150072009
    Abstract: A composition comprising mesoporous silica rods comprising an immune cell recruitment compound and an immune cell activation compound, and optionally comprising an antigen such as a tumor lysate. The composition is used to elicit an immune response to a vaccine antigen.
    Type: Application
    Filed: April 16, 2013
    Publication date: March 12, 2015
    Inventors: Jaeyun Kim, Weiwei Aileen Li, David J. Mooney