Abstract: This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a MEP precursor cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) modulator. In some embodiments the AhR modulator is an AhR antagonist. In some embodiments the AhR modulator is an AhR agonist. In some embodiments the methods comprise culturing MEP precursor cells in the presence of an AHR antagonist and then culturing MEP precursor cells in the presence of an AHR agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR modulator are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided.

Abstract: An electrified vehicle include a chassis, a front axle coupled to the chassis, a rear axle coupled to the chassis, an electric motor supported by the chassis, and a trailer coupled to a rear end of the chassis and configured to be towed by the electrified vehicle. The electric motor is configured to drive at least one of the front axle, the rear axle, or a component of the electrified vehicle. The trailer includes a trailer frame, a trailer axle coupled to the trailer frame, and an energy storage device supported by the trailer frame. The energy storage device includes a plurality of batteries. The energy storage device configured to power the electric motor.

Abstract: An antenna comprises first and second substrates with one or more spacers disposed therebetween so as to provide a substantially uniform an air gap between the substrates. Disposed on the first and second substrates are one or more antenna elements and disposed on at least one of the substrates is a feed circuit.

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

Abstract: Methods and devices for manipulating the temperature of a surface are generally provided. The present disclosure relates to a device including one or more heating and/or cooling elements, or other suitable thermal adjustment apparatus(es), placed near a surface, such as the skin of a user. The device may be configured to generate one or more (optionally alternating) thermal profiles at the surface, which may include a series of thermal pulses and/or essentially continuous or semi-continuous thermal input, which may vary over time. Such thermal profiles, when suitably applied, may provide enhanced thermal sensations for a user which, in some cases, may provide the user with a more pleasurable thermal experience than would otherwise be the case without the generation of the thermal profiles. In some embodiments, an alternating thermal profile may include an average frequency, an oscillation window, and/or an average temperature, each of which may be adjustable.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for allocating computing resources. In one aspect, a method includes receiving intent data specifying one or more computing services to be hosted by a computing network, requested characteristics of computing resources for use in hosting the computing service, and a priority value for each requested characteristic. A budget constraint is identified for each computing service. Available resources data is identified that specifies a set of available computing resources. A resource allocation problem for allocating computing resources for the one or more computing resources is generated based on the intent data, each budget constraint, and the available resources data. At least a portion of the set of computing resources is allocated for the one or more computing services based on results of evaluating the resource allocation problem to meet a particular resource allocation objective.

Abstract: A mobile phone may include a housing, a battery at least partially within the housing, and a circuit board assembly at least partially within the housing and positioned along a side of the battery. The circuit board assembly may include a first circuit board defining a first hole, a second circuit board defining a second hole, a wall structure between the first circuit board and the second circuit board and attached to an inner surface of the first circuit board and an inner surface of the second circuit board, and a fastener assembly configured to retain the first circuit board to the second circuit board.

Abstract: An ultrasonic instrument includes a body, an actuation assembly, a shaft assembly, and an end effector. The actuation assembly includes an activation member that is operable to move in a first direction to select a mode of operation. The shaft assembly extends distally from the body and includes an acoustic waveguide. The end effector includes an ultrasonic blade that is in acoustic communication with the acoustic waveguide. The activation member is operable to move in a second direction to activate the end effector in a mode of operation selected by movement of the activation member in the first direction.

Abstract: A bone plate can be used to fixate one or more bones. In some examples, the bone plate defines an elongated body having a plurality of fixation holes arrayed at different points along the length of the body. For example, the bone plate may have opposed fixation holes separated by a bridge. The bone plate may be bent or shaped along a central longitudinal axis extending through the elongated body and also twisted around the central longitudinal axis. The bending and twisting can position each fixation hole of the elongated body in a different plane in three-dimensional space.

Abstract: A vehicle includes a chassis including a frame rail extending longitudinally, a tractive element coupled to the chassis, an electric motor coupled to the chassis, a shaft coupling the electric motor to the tractive element such that the electric motor is configured to drive the tractive element to propel the vehicle, the shaft extending longitudinally, and a water pump configured to provide a flow of water in response to receiving mechanical energy provided by the electric motor.

Abstract: The technology disclosed herein enables automation of component sourcing when designing a process system in an industrial environment. In a particular embodiment, a method includes receiving design specifications of a process system in an industrial environment via a system design application. The method further includes determining components to implement the process system from the design specifications and identifying a first subset of the components for sourcing from an external provider. The method also includes populating the first subset into a component sourcing application.

Abstract: A method and apparatus for generating light includes a chamber having a high voltage region, a low voltage region, and a plasma generation region that defines a plasma confinement region. A magnetic core is positioned around the chamber and is configured to generate a plasma in the plasma confinement region. A switched power supply includes a DC power supply and a switched resonant charging circuit that together generate a plurality of voltage pulses at the output causing a plurality of current pulses to be applied to the power delivery section around the magnetic core so that at least one plasma loop is established around the magnetic core that confines plasma in the plasma confinement region, thereby forming a magnetically confined Z-pinch plasma. Light generated by the Z-pinch plasma propagates out of a port in the light source.

Abstract: Methods and systems for managing and/or processing a blockchain to maintain data security for confidential and/or personal data are provided. According to certain aspects, the disclosed data security techniques may enable access sharing functionality utilizing the blockchain. The data security techniques disclosed herein also enable the use of smart contracts to transfer funds associated with payment obligations. A node may receive a transaction indicative of a settlement condition of a smart contract being satisfied. Accordingly, the transaction may be compiled into a block of a blockchain and routed to the smart contract. The smart contract may direct a node to transfer funds in accordance with the payment obligations.

Abstract: Three dimensional nonwoven materials and methods of manufacturing such materials are disclosed. An absorbent article can include an absorbent body and an outer cover. The absorbent article can also include a fluid-entangled nonwoven material. The absorbent body can be disposed between the fluid-entangled nonwoven material and the outer cover. The fluid-entangled nonwoven can include a first surface and a second surface. The nonwoven material can also include a plurality of nodes extending away from abase plane on the first surface towards the absorbent body. The nonwoven material can further include a plurality of openings extending from the first surface to the second surface through the fluid-entangled nonwoven material. Individual openings of the plurality of openings can be disposed between adjacent nodes of the plurality of nodes.

Abstract: An electric brushless DC motor is provided including a rotor assembly having a substantially-cylindrical metallic rotor body and at least one rotor magnet mounted on a surface of the rotor body, a stator assembly rotatably disposed relative to the rotor assembly, and a molded structure formed in contact with the rotor body. The molded structure includes a first mold portion in engagement with the rotor body that integrally forms a fan at or adjacent an axial end of the rotor body, and a second mold portion extending integrally from the first mold portion at least partially in engagement with an inner surface of the rotor body. The second mold portion engages two axial ends of the at least one magnet to axially support and retain the at least one magnet relative to the rotor body.

Abstract: A brushless direct-current (BLDC) motor is provided. The motor includes a stator including a stator core, stator teeth, and windings; a rotor shaft disposed within the stator and extending along a longitudinal axis; and a rotor. The rotor includes a rotor core including a body extending around the longitudinal axis, a permanent magnet mounted on the body of the rotor core, and a mold structure formed at least partially through the rotor core. In an embodiment, the mold structure engages two axial ends of the permanent magnet to axially retain the permanent magnet relative to the rotor core and integrally forms a fan adjacent the rotor core. In an embodiment, the permanent magnet includes at least one tooth extending from an axial end thereof and having angled side edges, and the mold structure engages the at least one tooth to fixedly secure the permanent magnet to the rotor core.

Abstract: Described herein are methods of modulating OTC gene transcription using antisense oligonucleotides (ASOs) targeting regulatory RNAs, such as promoter-associated RNAs and enhancer RNAs. These methods are useful for increasing expression of Ornithine transcarbamylase (OTC), thereby treating diseases associated with aberrant gene expression.

Abstract: A rotary tool assembly includes a rotary tool having a body with a working end and a rear end, a motor disposed within the body, and a drive shaft rotatably driven by the motor. A base of the rotary tool assembly includes a battery receptacle configured to receive a battery pack and a stand for supporting the rotary tool when the rotary tool is not in use. The stand includes two arms defining a tool receptacle therebetween in which the rotary tool is supported. A power cord extends between the base and the rotary tool to transfer electric power from the base to the rotary tool to selectively power the motor. The battery pack is received in the battery receptacle for form a foot of the base.

Abstract: A stator assembly for a BLDC motor includes a stator core, at least one magnet wire wound on poles of the stator core, an end insulator mounted on an end surface of the stator core, a non-conductive mount member mounted on the outer circumferential surface of the stator core, and conductive terminals mounted on the non-conductive mount member. Each conductive terminal includes: a main portion mounted on the non-conductive mount, a tang portion extending from a first longitudinal end adjacent the end insulator and folded over the main portion, and a connection tab extending angularly from a second longitudinal end. A contact portion of the magnet wire is wrapped around the tang portion and fused to make an electric connection to the conductive terminal.

Abstract: A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.