Abstract: Disclosed herein are engineered AAV VP capsid polypeptides with the ability to assemble into virus particles and having improved tissue tropism to, for example, CNS tissues. The capsids are engineered using the high throughput discovery system described herein. In certain embodiments, provided herein are recombinant adeno-associated virus (AAV) VP capsid polypeptides having at least one mutation in a residue corresponding to residue 581 to residue 589 in SEQ ID NO: 1.

Abstract: A water softener system includes a brine tank, an ion-exchange resin and a softener control valve fluidly coupling the brine tank and the ion-exchange resin. The softener control valve has an inlet configured to receive a flow of feed-water and an outlet configured to deliver a flow of product water. A flow meter is configured to monitor a flow rate of water to or from the control valve, and a sensor is arranged upstream of the inlet of the softener control valve to measure a fluid property of the flow of feed-water. A controller is configured to calculate an available exchange capacity of the ion-exchange resin using flow rate data from the flow meter and a hardness value of the feed-water, which the controller calculates using a fluid property value from the sensor and a predetermined coefficient.

Abstract: A coaxial cable connector assembly includes a coupler, a rear body assembly rotatably engaged with the coupler, the rear body assembly including a stationary retention member defining an stationary retention member inner channel surface and one or more stationary retention member grooves extending inwardly from the stationary retention member inner channel surface, a movable retention member that is movable with respect to the stationary retention member in an axial direction, the movable retention member defining a movable retention member inner channel surface and one or more movable retention member grooves extending inwardly from the movable retention member inner channel surface, the one or more movable retention member grooves defining a movable retention member groove surface, and one or more compression rings positioned at least partially within the one or more stationary retention member grooves.

Abstract: Provided herein are binding molecules, such as those that recognize or bind a peptide epitope of a cancer antigen, such as expressed on a cancer cell, including cells infected with human papilloma virus (HPV) or that contain HPV DNA sequences and/or those that recognize or bind a peptide epitope of HPV 16 E6 or E7, in the context of a major histocompatibility complex (MHC) molecule. Among the provided binding molecules are T cell receptors (TCRs) or antibodies, including antigen-binding fragments thereof, that bind or recognize such peptide epitopes. The present disclosure further relates to engineered cells comprising such binding molecules, e.g., TCRs or antibodies (and chimeric antigen receptors containing the antibodies), and uses thereof in adoptive cell therapy.

Abstract: A coaxial cable connector assembly comprising a rear body comprising an outer body member and an inner body member, wherein the rear body is positionable in a disengaged position and an engaged position, and a coupler rotatably engaged with and positioned forward of the rear body, wherein the coupler defines an inner channel extending through the coupler between a front portion of the coupler and a rear portion of the coupler positioned opposite the front portion, a thread at the front portion of the coupler, a nominal portion defining a nominal inner span along the inner channel, and an outer conductor engagement portion that tapers inwardly from the nominal portion that extends forwardly along the inner channel to the front portion of the coupler, wherein the outer conductor engagement portion is structurally configured to contact an outer conductor of the coaxial cable.

Abstract: A method for coupling a coaxial cable to a coaxial cable connector assembly includes inserting a coaxial cable into a cable channel of a rear body of a coaxial cable connector assembly, where the coaxial cable connector assembly includes an adhesive reservoir positioned at least partially within the cable channel of the rear body, the adhesive reservoir comprising an adhesive and an adhesive reservoir seal material that at least partially encapsulates the adhesive, inserting at least a portion of the coaxial cable into the adhesive reservoir, and exposing the adhesive to electromagnetic energy thereby curing the adhesive, by at least one of directing electromagnetic energy from an energy source on the adhesive, and removing an outer jacket from an outer wall of the rear body.

Abstract: A coaxial cable connector assembly including a rear body, a coupler rotatably engaged with the rear body, where the coupler defines an inner channel extending through the coupler between a front portion of the coupler and a rear portion of the coupler, and a nominal portion defining a nominal inner span along the inner channel, and a retainer engaged with the coupler and the rear body, where the retainer couples the coupler to the rear body, where at least one of the retainer and the coupler defines an engagement passage having a non-uniform span, where at least a portion of the engagement passage extends inwardly from the nominal portion of the coupler and is structurally configured to contact an outer conductor of the coaxial cable forming an electrical pathway between the thread of the coupler and the outer conductor of the coaxial cable.

Abstract: A coaxial cable connector assembly includes a coupler defining an inner channel extending through the coupler and an outer conductor engagement feature extending inwardly from the inner channel, a rear body, positioned rearward of the coupler, defining a cable channel extending through the rear body, and structurally configured to receive the coaxial cable, and an adhesive reservoir positioned at least partially within the cable channel of the rear body, the adhesive reservoir including an adhesive and an adhesive reservoir breakable material that encapsulates the adhesive, where the adhesive reservoir breakable material is structurally configured to fracture upon the application of force exceeding a predetermined threshold, thereby releasing the adhesive from the adhesive reservoir to adhesively couple the coaxial cable to the rear body.

Abstract: A coaxial cable connector assembly includes a coupler, a rear body assembly rotatably engaged with the coupler, the rear body assembly including a stationary retention member defining an stationary retention member inner channel surface and one or more stationary retention member grooves extending inwardly from the stationary retention member inner channel surface, a movable retention member that is movable with respect to the stationary retention member in an axial direction, the movable retention member defining a movable retention member inner channel surface and one or more movable retention member grooves extending inwardly from the movable retention member inner channel surface, the one or more movable retention member grooves defining a movable retention member groove surface, and one or more compression rings positioned at least partially within the one or more stationary retention member grooves

Abstract: An apparatus to remove ions including a plurality of capacitive electrode stacks. Each capacitive electrode stack may have: a plurality of first electrodes including a plurality of first current collectors; a plurality of second electrodes including a plurality of second current collectors; and a spacer between the first and second electrodes to allow water to flow in between the electrodes. The second current collectors of a first of the plurality of capacitive electrode stacks may be connected to the first current collectors of a second of the plurality of capacitive electrode stacks.

Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

Abstract: A massager providing massaging frequencies in the range of 75 to 250 hertz, and preferably 100 to 200 Hertz is provided. The massager includes a motor for generating rotational motion, an applicator head having multiple treatment surfaces, and a shaft attached to the motor and applicator head for translating the rotational motion to the applicator head. The massager also includes a restraining mechanism attached to the applicator head. The restraining mechanism is configured to prevent the applicator head from rotating, thereby generating a circular motion in each of the treatment surface. The circular motion has diameters in a range of 0.1 mm to 5 mm and a preferred frequency of 100-200 completed circular movements per second.

Abstract: The present invention describes a device and system for simulating normal and disease state cardiovascular functioning, including an anatomically accurate left cardiac simulator for training and medical device testing. The system and device uses pneumatically pressurized chambers to generate ventricle and atrium contractions. In conjunction with the interaction of synthetic valves, which simulate mitral and aortic valves, the system is designed to generate pumping action that produces accurate volume fractions and pressure gradients of pulsatile flow, duplicating that of a human heart.

Abstract: A system for lifting a wheelchair into and out of a vehicle is provided. The system includes a driver side and a passenger side wheelchair supports, a driver side and a passenger side extendable lift assemblies, and a control system. The driver side extendable lift assembly is arranged to move the driver side wheelchair support between a stowed position within the vehicle and a deployed position extended horizontally outside the vehicle and lowered towards the ground. The passenger side extendable lift assembly is arranged to move the passenger side wheelchair support between its stowed position and its deployed position. The control system is configured to independently operate the driver side extendable lift assembly and the passenger side extendable lift assembly to separately or simultaneously move the driver side wheelchair support and the passenger side wheelchair support between their respective stowed positions and their respective deployed positions.

Abstract: A method of immunising a human female subject to decrease the risk of Group B Streptococcus (GBS) disease in an infant born to the subject, by providing a priming dose of a GBS vaccine and, more than thirty days after the priming dose, providing a boosting dose of a GBS vaccine.

Abstract: The preparation of an oxidative dehydrogenation catalyst comprising Mo, V, Nb and Te using a hydrothermal step. In some embodiments, the activity and reproducibility of the catalyst is improved by conducting the hydrothermal step while permitting gaseous products to leave the reactor. In some instances a condenser may be upstream of the outlet of the reactor.

Abstract: A system for adjusting the fit of an article of clothing and to provide other benefits including, but not limited to, reduction and/or elimination of wind drag, reduction of loose clothing that can get caught or cause obstruction, regulation of blood circulation, movement, and swelling of the wearer of the article of clothing, adjustment of ventilation, general enhancement of the clothing for a desired activity, and general comfort and/or desired appearance. The system comprises one or more closures at various locations of the article of clothing to enable the wearer to adjust the fit of the clothing when desired.

Abstract: Oxidative dehydrogenation catalysts comprising MoVNbTeO having improved consistency of composition and a 25% conversion of ethylene at less than 420° C. and a selectivity to ethylene above 95% are prepared by treating the catalyst precursor with H2O2 in an amount equivalent to 0.30-2.8 mL H2O2 of a 30% solution per gram of catalyst precursor prior to calcining.

Abstract: A catalyst for oxidative dehydrogenation (ODH) of ethane with an empirical formula Mo—V—Te—Nb—Pd—O produced using a process comprising impregnation of the Pd component on the surface of the catalyst following a calcination step using a Pd compound free of halogens. The resulting catalyst can be used in both diluted and undiluted ODH processes and shows higher than expected activity without any loss of selectivity.

Abstract: A catalyst for oxidative dehydrogenation (ODH) of ethane with an empirical formula Mo—V—Te—Nb—Pd—O produced using a process comprising impregnation of the Pd component on the surface of the catalyst following a calcination step using a Pd compound free of halogens. The resulting catalyst can be used in both diluted and undiluted ODH processes and shows higher than expected activity without any loss of selectivity.