Abstract: The present disclosure relates to a positive pressure breathing circuit and a method for ventilating a patient. The breathing circuit can be used in any type of pressurized breathing therapy including, for example, continuous positive air (way) pressure (CPAP) therapy and bilevel positive air pressure therapy where the inspiratory and expiratory pressures differ.

Abstract: Described herein are compounds of Formula I: I and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R7, RF, t1, Y1, and Y2 are defined herein; their use as MC4R antagonists; pharmaceutical compositions containing such compounds and salts; the use of such compounds and salts to treat, for example, cachexia, anorexia, or anorexia nervosa; and intermediates and processes for preparing such compounds and salts.

Abstract: A conduit for a breathing circuit includes a heater associated, at least in part, with a hydrophilic layer. The purpose of the heater is to evaporate any condensed liquid collecting in the conduit, which is first sucked up by the hydrophilic layer. The heated wick reduces the risk of collected water being passed to the patient and causing choking fits or discomfit. It is preferred that the heated wick lies freely in the conduit to settle at low points in the conduit where condensation may collect.

Abstract: The various systems and methods disclosed herein provide an enhanced audio experience in a virtual environment. In some implementations of the system and method for enhancing audio, a user forms a group with one or more desired audio sources in a virtual environment, and audio coming from sources outside of the group are filtered to become less obtrusive. In some implementations, causing non-group audio to become less obtrusive is accomplished by lowering its perceived volume.

Abstract: Delivery devices for delivering an ophthalmic device into an eye. In some embodiments the delivery devices are adapted to deliver an intraocular lens into an eye.

Abstract: Delivery devices for delivering an ophthalmic device into an eye. In some embodiments the delivery devices are adapted to deliver an intraocular lens into an eye.

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: A system for uncertainty prediction is provided. The system includes at least one target system including at least one target device and configured to generate data corresponding to a plurality of parameters of the target device. The system further includes a computing device including a processor configured to receive, during a training phase, first data obtained from the at least one target system, perform a Monte Carlo simulation to generate a first plurality of uncertainty intervals based on the first data, and generate a machine learning model by training using the first plurality of uncertainty intervals and the first data. The processor is further configured to receive, during a prediction phase, second data from the at least one target system and generate, using the machine learning model, a second plurality of uncertainty intervals based on the second data.

Abstract: A bidirectional gas discharge tube (GDT) includes a discharge chamber, first and second cathodes, a gas disposed within the discharge chamber, and a control grid. The first and second cathodes are disposed within the discharge chamber and include first and second faces, respectively. The first face and the second face are plane-parallel. The gas is configured to insulate the first cathode from the second cathode. The control grid is disposed between the first and second cathodes within the discharge chamber. The control grid is configured to generate an electric field to initiate establishment of a conductive plasma between the first and second cathodes to close a conduction path extending between the first and second cathodes.

Abstract: A DC circuit breaker includes a gas discharge tube (GDT) coupled in parallel with an extinguishing path. The GDT conducts and interrupts a load current through a normal current path. The GDT includes a thermionic cathode, an anode, and a control grid. The control grid is configured to regulate opening and closing of the normal current path. The extinguishing path is configured to lengthen a break time for the DC circuit breaker.

Abstract: A DC circuit breaker includes a gas discharge tube (GDT) coupled in parallel with an extinguishing path. The GDT conducts and interrupts a load current through a normal current path. The GDT includes a thermionic cathode, an anode, and a control grid. The control grid is configured to regulate opening and closing of the normal current path. The extinguishing path is configured to lengthen a break time for the DC circuit breaker.

Abstract: A bidirectional gas discharge tube (GDT) includes a discharge chamber, first and second cathodes, a gas disposed within the discharge chamber, and a control grid. The first and second cathodes are disposed within the discharge chamber and include first and second faces, respectively. The first face and the second face are plane-parallel. The gas is configured to insulate the first cathode from the second cathode. The control grid is disposed between the first and second cathodes within the discharge chamber. The control grid is configured to generate an electric field to initiate establishment of a conductive plasma between the first and second cathodes to close a conduction path extending between the first and second cathodes.

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: A water-soluble pouch suitable for use in machine dishwashing and which comprises a plurality of compartments in generally superposed or superposable relationship, each containing one or more detergent active or auxiliary components, and wherein the pouch has a volume of from about 5 to about 70 ml and a longitudinal/transverse aspect ratio in the range from about 2:1 to about 1:8, preferably from about 1:1 to about 1:4. The water-soluble pouch allows for optimum delivery of dishwashing detergent. A process for the manufacture of multi-compartment pouches and a pack to contain the pouches are also disclosed.

Abstract: Disclosed is a system for assessing user interaction with a simulated reality environment. The system includes a user device, sensor(s), a computer readable instructions, and a processor. The sensor(s) detect user data associated a simulated real world task in the simulated reality environment related to at least one of biological indicator, user interactional input, and behavioral user activity. The processor is configured to cause display, on the user device, of the simulated reality environment configured for user interaction with the simulated real world task; receive, from the sensor(s), data related to the detected user data associated with the simulated real world task; determine, based on the received user data, a confidence grade for the user. The confidence grade is indicative of the user's confidence in performance of the simulated real world task within the simulated reality environment. The processor causes transmission of feedback related to the confidence grade.

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: A cold-cathode switching device is presented. The cold-cathode switching device includes a housing defining a chamber; an ionizable gas disposed in the chamber; and a plurality of electrodes disposed in the chamber. The plurality of electrodes includes a cathode and an anode defining a discharge gap, and wherein at least one of the cathode and anode comprises a material that is liquid at an operating temperature of the cathode or the anode.

Abstract: Delivery devices for delivering an ophthalmic device into an eye. In some embodiments the delivery devices are adapted to deliver an intraocular lens into an eye.

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.