Abstract: Novel fully human anti-VAP-1 antibodies and fragments thereof are disclosed. Nucleic acids encoding anti-VAP-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-VAP-1 antibodies are also given. Pharmaceutical compositions comprising said antibodies and therapeutic uses thereof are also disclosed.

Abstract: Capsules, for example for the delivery of pharmaceuticals, are produced from two films (18) of a water-soluble polymeric material, by deforming the films to form a multiplicity of recesses, and filling the recesses, using two adjacent rotary dies (14, 15; 42) with recesses (16) into which the films (18) are deformed. The dies (14, 15; 42) act as electrodes for welding the films together by dielectric welding to form filled capsules (30). The capsules (30) can be separated from the resulting web either by coating at least one of the dies (14) with an electrical insulator (21), or by transferring the web from the dies (14, 15; 42) to a second pair of dies which cut the capsules (30) free. The polymeric material may be gelatin, or a water-soluble cellulose derivative such as hydroxypropyl methyl cellulose, and may also contain a plasticiser.

Abstract: A radiation source is presented, the source comprising an ionizable mercury-free composition that comprises tin halide such that the halide to tin ratio is greater than 2.

Abstract: Delivery devices for delivering an ophthalmic device into an eye. In some embodiments the delivery devices are adapted to deliver an intraocular lens into an eye.

Abstract: Post-implant modifications to an intraocular lens. In some embodiments the lens is an accommodating intraocular lens.

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: A water-soluble pouch suitable for use in machine dishwashing and which comprises a plurality of compartments in generally superposed or superposable relationship, each containing one or more detergent active or auxiliary components, and wherein the pouch has a volume of from about 5 to about 70 ml and a longitudinal/transverse aspect ratio in the range from about 2:1 to about 1:8, preferably from about 1:1 to about 1:4. The water-soluble pouch allows for optimum delivery of dishwashing detergent. A process for the manufacture of multi-compartment pouches and a pack to contain the pouches are also disclosed.

Abstract: A water-soluble pouch suitable for use in machine dishwashing and which comprises a plurality of compartments in generally superposed or superposable relationship, each containing one or more detergent active or auxiliary components, and wherein the pouch has a volume of from about 5 to about 70 ml and a longitudinal/transverse aspect ratio in the range from about 2:1 to about 1:8, preferably from about 1:1 to about 1:4. The water-soluble pouch allows for optimum delivery of dishwashing detergent. A process for the manufacture of multi-compartment pouches and a pack to contain the pouches are also disclosed.

Abstract: A water-soluble pouch suitable for use in machine dishwashing and which comprises a plurality of compartments in generally superposed or superposable relationship, each containing one or more detergent active or auxiliary components, and wherein the pouch has a volume of from about 5 to about 70 ml and a longitudinal/transverse aspect ratio in the range from about 2:1 to about 1:8, preferably from about 1:1 to about 1:4. The water-soluble pouch allows for optimum delivery of dishwashing detergent. A process for the manufacture of multi-compartment pouches and a pack to contain the pouches are also disclosed.

Abstract: A radiation source with an ionizable mercury-free composition. The ionizable composition including at least zinc or at least one zinc compound or both.

Abstract: Process for treating or recycling a waste single or multi-compartment detergent pouch containing one or more detergent or detergent auxiliary compositions enclosed within a water-soluble enveloping material.

Abstract: A water-soluble pouch suitable for use in machine dishwashing and which comprises a plurality of compartments in generally superposed or superposable relationship, each containing one or more detergent active or auxiliary components, and wherein the pouch has a volume of from about 5 to about 70 ml and a longitudinal/transverse aspect ratio in the range from about 2:1 to about 1:8, preferably from about 1:1 to about 1:4. The water-soluble pouch allows for optimum delivery of dishwashing detergent. A process for the manufacture of multi-compartment pouches and a pack to contain the pouches are also disclosed.

Abstract: A half wave dielectric resonator assembly including a resonator cavity having a top surface and a bottom surface, an elongated cylindrical dielectric resonator positioned within said resonator cavity and first and second insulative supports to couple and insulate the ends of the cylindrical dielectric resonator from the resonator cavity. The dielectric resonator has a substantially small diameter to length ratio. The resonator assembly provides improved spurious performance and quality factor (Q) at a lower mass. A resonator filter is constructed using a plurality of these resonator assemblies, where adjacent pairs of said resonator cavities are separated from each other by a common cavity wall. By forming a first iris opening formed within a first common cavity wall and forming a second iris opening formed within a second common cavity wall having a position that is vertically offset from the position of the first iris, it is possible to reduce stray coupling.

Abstract: The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R1 to R11 are as defined herein.

Abstract: A method of washing dishware/tableware in an automatic dishwashing machine having a single or multi-compartment product dispenser which is normally closed and sealed after charging the machine and prior to delivery of the dishwashing product into the wash liquor and wherein the dishwashing product comprises one or more dishwashing compositions in a unit dose form having a degree of deformability greater than about 10% and a shape and size such that the dishwashing product occupies more than about 40% of the volume of the corresponding compartment of the product dispenser in its closed state. The method allows for optimum delivery of active components across different washing machine types.

Abstract: The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases.

Abstract: Process for treating or recycling a waste single or multi-compartment detergent pouch containing one or more detergent or detergent auxiliary compositions enclosed within a water-soluble enveloping material.

Abstract: A drain cleaner with soy methyl ester (SME) CAS #66784-80-9 utilized at 92.8% by weight, the emulsifier system composed of combination of lauramide DEA and secondary alcohol ethoxylate CAS #'s 120-40-1 and 68131-40-8 utilized at 7% and a butylated hydroxytoluene CAS #128-37-1 used as an anti-oxidant at 0.2%.

Abstract: A vacuum-assisted process for making a fluid-containing water-soluble pouch. The pouches obtained according to the process of the invention have a reduce air content. The use of the pouches containing detergent composition for laundry and dishwashing is also disclosed.

Abstract: The present invention is directed to hydrazono compounds that function as inhibitors of copper-containg amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases.