Abstract: The present invention is directed to hydrazono compounds that function as inhibitors of copper-containg amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases.

Abstract: A method of washing dishware/tableware in an automatic dishwashing machine having a single or multi-compartment product dispenser which is normally closed and sealed after charging the machine and prior to delivery of the dishwashing product into the wash liquor and wherein the dishwashing product comprises one or more dishwashing compositions in a unit dose form having a degree of deformability greater than about 10% and a shape and size such that the dishwashing product occupies more than about 60%, preferably more than about 85% of the volume of the corresponding compartment of the product dispenser in its closed state. The method allows for optimum delivery of active components across different washing machine types.

Abstract: The present invention relates to a detergent system comprising a plurality of pre-formed subunits wherein at least one of the subunits is a liquid, paste or gel-filled water-soluble capsule or pouch and wherein the subunits are packaged together in a water-soluble film wrap.

Abstract: A method of preparing a contact mass is provided comprising reacting silicon and a cuprous chloride to form a concentrated, catalytic contact mass. Furthermore, a method for making an alkylhalosilane using the aforementioned contact mass is provided comprising effecting reaction between an alkyl halide and silicon in the presence of said concentrated contact mass to produce alkylhalosilane.

Abstract: The present invention is directed to hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R1 to R8 and X are as defined herein.

Abstract: A detergent tablet containing a nonionic surfactant having a melting point above ambient temperature is suitable for use in an automatic dishwasher or laundry washing machine. Additionally, a process for making a detergent tablet containing such a nonionic surfactant is described.

Abstract: The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containg amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases.

Abstract: The present invention is directed to hydrazono compounds that function as inhibitors of copper-containg amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases.

Abstract: A water-soluble pouch suitable for use in machine dishwashing and which comprises a plurality of compartments in generally superposed or superposable relationship, each containing one or more detergent active or auxiliary components, and wherein the pouch has a volume of from about 5 to about 70 ml and a longitudinal/transverse aspect ratio in the range from about 2:1 to about 1:8, preferably from about 1:1 to about 1:4. The water-soluble pouch allows for optimum delivery of dishwashing detergent. A process for the manufacture of multi-compartment pouches and a pack to contain the pouches are also disclosed.

Abstract: A method of washing dishware/tableware in an automatic dishwashing machine having a single or multi-compartment product dispenser which is normally closed and sealed after charging the machine and prior to delivery of the dishwashing product into the wash liquor and wherein the dishwashing product comprises one or more dishwashing compositions in a unit dose form having a degree of deformability greater than about 10% and a shape and size such that the dishwashing product occupies more than about 60%, preferably more than about 85% of the volume of the corresponding compartment of the product dispenser in its closed state. The method allows for optimum delivery of active components across different washing machine types.

Abstract: A process for preparing a multi-phase detergent tablet comprising the steps of: a) forming a tablet body by compressing a granular detergent mixture, said tablet body having a first surface, said first surface having at least one mold therein and said granular detergent mixture comprises at least one detergent active agent; b) providing a gelatinous mixture under constant agitation, and delivering said gelatinous mixture to said at least one mold in said tablet body to form a gelatinous portion, said gelatinous mixture comprises at least one detergent active agent; and c) hardening or curing said gelatinous portion to form a multi-phase detergent tablet.

Abstract: The present invention provides a detergent tablet comprising a nonionic surfactant having a melting point above ambient temperature suitable for use in an automatic dishwasher or laundry washing machine.

Abstract: Methods and systems are provided for communicating to multiple functions on a single adapter device over an external communications bus, where the external communications bus is configured so as to allow only a single access point to the external communications bus for each adapter device. Communications on the external communications bus are provided through the single access point to functions of a first type in the adapter device utilizing a function specific communications interface configured for communicating with functions of the first type. Communications on the external communications bus are also provided through the single access point to functions in the adapter device other than functions of the first type utilizing management capabilities of the function specific communications interface so as to provide communications with the functions of the second type without modifying the configuration of the function specific communications interface.

Abstract: DNA encoding the gene for the synthetase enzyme capable of generating &dgr; (L-a-aminoadipyl)-L-crysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and cephalosporin producing organisms, e.g. Penicillium chrysogenum, cephalosporium and a Flavobacterium species. The DNA was used to prepare recombinant vectors comprising the ACV synthetase gene and hosts transformed with such vectors. The ACV synthetase gene can form part of a gene cluster comprising other genes involved in -&bgr;-lactam biosynthesis and the production of penicillin by expression of the entire biosynthetic gene cluster for the synthesis of penicillin from primary amino acids is described. Suitable hosts in which expression can take place include heterologous hosts which are naturally non-producers of penicillin.

Abstract: A process for the manufacture of detergent compositions from a surfactant paste which is substantially in the solid phase at temperatures of 25.degree. C. and below comprises the steps of: (i) mixing the surfactant paste at a temperature above its softening point, the surfactant paste comprising at least 50% by weight of nonionic surfactant; (ii) forming the molten surfactant paste into drops on a cooling surface; (iii) forming solid pastilles by cooling the drops of molten surfactant paste; and (iv) removing solidified pastilles from the cooling surface.