Abstract: The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

Abstract: A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.

Abstract: A thermal management system for an aircraft includes a first gas turbine engine, first thermal bus, first heat exchanger, one or more first ancillary systems, vapour compression system, one or more second ancillary systems and second heat exchanger. A waste heat energy generated by a first gas turbine engine, and a first ancillary system, transfers to the first heat transfer fluid. A waste heat energy generated by a second ancillary system transfers to a second heat transfer fluid, and the second heat exchanger transfers the waste heat energy from the second heat transfer fluid to the first heat transfer fluid. The waste heat energy generated by a second ancillary system transfers to the first heat transfer fluid, and the first heat exchanger transfers the waste heat energy to a dissipation medium. The waste heat energy transferred to the second heat transfer fluid ranges from 20 kW to 300 kW.

Abstract: This disclosure describes techniques that enable a carrier aggregation of two or more carrier available carriers for uplink transmissions at a base station node. More specifically, a carrier aggregation controller may receive a resource allocation request from a base station node that is associated with an uplink transmission of user plane data from a client device. The carrier aggregation controller may determine a carrier aggregation for the uplink transmission and generate scheduling information for delivery to the base station node that is based at least in part on the carrier aggregation.

Abstract: A data processing system implements obtaining, at a file services platform, first mapping information by mapping files, folders, or a combination thereof stored on each of a plurality of client devices associated with a first user. The data processing system further implements synchronizing the first mapping information with the plurality of client devices, receiving a first request for a first file from a first client device of the plurality of client devices, where the first file stored locally on a second client device of the plurality of client devices. The data processing system further implements requesting that the second client device upload an instance of the first file to the file services platform; receiving the instance of the first file from the second client device; and causing the first client device to download the instance of the first file from the file services platform to the first client device.

Abstract: A recyclable, laminated polyolefin-based film structure comprises two or more film plies laminated to each other. Each of the laminated film plies comprises one or more polyolefin-based films. The film structure has an energy-cured coating layer disposed on the outermost outward facing surface of the film structure and a printed ink layer on an interior surface of one of the polyolefin-based polyolefin layers. In certain embodiments, the outermost surface of the laminated polyolefin-based film structure has a melting temperature which is at least 100 degrees Celsius, and more preferably 180 degrees Celsius, higher than a melting temperature of the innermost surface of the laminated polyolefin-based film structure.

Abstract: The present disclosure relates to various solid-state forms of N-hydroxy 2-{6-[(6-fluoro-quinolin-2-ylmethyl)-amino]-3-aza-bicyclo[3.1.0]hex-3-yl}pyrimidine-5-carboxamide and methods of making the same. Such forms of N-hydroxy 2-{6-[(6-fluoro-quinolin-2-ylmethyl)-amino]-3-aza-bicyclo[3.1.

Abstract: In a method for advanced identification of a customer, a customer may remotely place an order, intending to later go to a store to pick up the ordered item. The store may have a pick-up area (e.g., at the back of the store) where the customer can go to pick up the ordered item. To save the customer time, the customer may be identified when she enters the store so that an employee can obtain her ordered item and have it ready to pick up by the time the customer walks through the store and arrives at the pick-up area.

Abstract: A steering wheel control interface module that can automatically detect the type of vehicle it is installed in and automatically detect the type of aftermarket radio it is sending messages to. In addition, the interface module can retain certain user pre-selects and use those to properly set the state of an aftermarket radio.

Abstract: Provided are methods and compositions comprising antibodies capable of specific binding to human CEACAM1 molecules, for treating and diagnosing cancer as well as assessing CEACAM1 expression in tumor infiltrating immune cells (TILs) in a biological sample obtained from a [cancer] subject.

Abstract: An analysis of the scans is performed to determine whether the selected item was moved from the back room to the shelf, then returned from the shelf to the back room. The analysis also determines a re-bin time when the selected product was returned to the back room. An adjustment to the PI is blocked when last PI adjustment time is later than the re-bin time. An adjustment to the PI is also blocked when an audit indicator is received at the interface indicating that the retail store is under an audit. An adjusted PI value is determined when the analysis indicates that the selected item was moved from the back room to the shelf, then returned from the shelf, the adjusted PI value being at least one more than the shelf capacity value.

Abstract: A vehicle includes a cabin interior, a dashboard located in the cabin interior, and a desk supported on the dashboard and movable between a stowed position on the dashboard and a deployed position extending outward from the dashboard, the desk comprising a plurality of interconnected panels having arms configured to engage a track to bend around at least a portion of the dashboard, and wherein the desk operably moves along the track when moved between the stowed position and the deployed position.

Abstract: A vehicle includes a body defining a cabin having an interior and a passenger door, an interior panel located in the interior, a track located in the passenger door within the interior, and a desk operably housed in a slot in the interior panel and slidably coupled to the slot in the interior panel and the track to move between a stowed position within the interior panel and a use position extending outward from the interior panel.

Abstract: A fuel management system includes: a fuel tank; a fuel supply line that supply fuel from the fuel tank to a combustor of the gas turbine engine; a reheat fuel supply line that supply fuel from fuel tank to a reheat of the gas turbine engine, the reheat fuel supply line extending from a reheat branching point on the fuel supply line to the reheat; a fuel supply pump disposed along fuel supply line upstream of the reheat branching point; a reheat pump disposed along reheat fuel supply line, the reheat pump that pressurise fuel to a reheat delivery pressure for delivery to the reheat; and a reheat recirculation line that recirculate fuel from the reheat fuel supply line to a location upstream of fuel supply pump, the reheat recirculation line extending from a reheat recirculation branching point on the reheat fuel supply line downstream of the reheat pump.

Abstract: The invention provides an ocular composition comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent. The composition can be used to form an ocular implant and an in situ ocular implant.

Abstract: A thermal management system for an aircraft includes a first gas turbine engine, one or more first electric machines, first thermal bus and heat exchanger. The first thermal bus includes a first heat transfer fluid in a closed loop flow sequence, between the first gas turbine engine, or each first electric machine, and the first heat exchanger. Waste heat energy transfers to the first heat transfer fluid. The first heat exchanger configures to transfer waste heat energy from the first heat transfer fluid to a dissipation medium. During steady-state operation of the first gas turbine engine, the first heat transfer fluid entering the first heat exchanger has a temperature of TFLUID(° C.), and a temperature of an inlet air flow entering the first gas turbine engine has a temperature TAIR(° C.) and a ratio B is in a range of between 5.0-18.0.

Abstract: A milling device for machining a slot into an inner surface of a casing for a gas turbine engine. The milling device includes a frame assembly including multiple structural guides configured to engage structural features on the inner surface of the casing to maintain an axial position of the milling device relative to a longitudinal axis of the casing. The milling device also includes a milling cutter coupled to the frame assembly. The milling device is configured to be displaced in a circumferential direction relative to the longitudinal axis to machine the slot, via the milling cutter, along the inner surface of the casing in the circumferential direction.

Abstract: Techniques for standardizing a catalog of data and for using the standardized data to implement various APIs are disclosed. Non-standardized data is received. This data includes information describing items, customer information, and unstructured review data. The non-standardized data is converted to a standardized format, resulting in the generation of standardized data. The standardized data includes a hierarchy of defined categories. Each category is associated with a set of attribute types. The standardized data also includes anonymized profiles. The unstructured review data is also provided structure. A data model is generated based on the standardized data. Various APIs can then use the data model to perform operations.