Abstract: The invention relates to a rail vehicle (1) comprising a first passenger car and a powerpack (2) having a longitudinal axis, the powerpack (2) and the passenger car being coupled together. The powerpack (2) comprises at least one fuel cell (20) and at least one fuel tank (21) having a fuel tank valve (33). The powerpack (2) is mounted on at least one bogie. The rail vehicle (1) comprises at least one driven bogie which can be supplied with electrical energy from the fuel cell (20).

Abstract: A 3D printing apparatus and method determines features based on design data of an object and at least one classification of a determined feature. The at least one classification includes a classification that the determined feature is a critical feature for the object. At least one print setting for forming the determined feature is modified based on the classification that the determined feature is a critical feature.

Abstract: Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-associated disorder or disease and methods of diagnosing a KIT-associated disorder or disease using the antibodies described herein.

Abstract: This disclosure describes techniques that enable a telecommunications network to share available bandwidth within a cell of base station node between different air-interface technologies, such as Long-Term Evolution (LTE) and 5G-New Radio (5G-NR). This disclosure further enables spectrum allocation to service segments of a base station node. A spectrum allocation controller is described that is configured to identify, within a service area of a base station node, available spectrum, and in doing so, allocate available spectrum to non-overlapping service segments.

Abstract: Provided herein are compositions, methods and uses involving antibodies that specifically bind to MET, a receptor tyrosine kinase, and modulate the expression and/or activity of MET. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. In one aspect, provided herein is a monoclonal antibody or antigen-binding fragment thereof that binds to the Sema/PSI domain of human MET. Also provided herein is a kit comprising an antibody or antigen-binding fragment provided herein. Also provided herein is a method of managing, protecting against, or treating cancer in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment provided herein.

Abstract: A software development infrastructure can enable user developers to select remote hardware devices to develop and test their software programs. For some tests and development activity, physical access to the remote device can be provided by the infrastructure administrator by replacing the internal calls of an application with mimic code, which can respond to application requests for sensor data, as if the user was physically handling the remote device at the same location.

Abstract: Humanized antibodies, capable of specific binding to human CEACAM1 molecules containing human-to-murine back-mutations in non-CDR variable regions, and their encoding polynucleotide sequences are provided. Pharmaceutical compositions comprising these antibodies as well as methods of their use in treating and diagnosing cancer and other conditions are also provided.

Abstract: The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

Abstract: Techniques are described for a video survey. One method includes providing a video survey to a customer or a potential customer of a service, sale, product, or system. The video survey may be provided before, during, or after a provided service. In some cases, the customer or the potential customer may provide one or more responses to one or more requests included in the video survey. The video survey may record the one or more responses to the one or more requests. In some examples, the provided responses may be a video response, an audio response, a tactile response, or any combination thereof. The video survey may proceed or conclude based on the response being a positive response or a negative response.

Abstract: A presaturated wiping product is disclosed well suited for destroying non-enveloped viruses, including the Norovirus. The wiping composition contains a first anti-microbial agent blended with a second agent, such as a preservative. Even at very low concentrations within the wiping composition, the wiping products can completely destroy and kill non-enveloped viruses at relatively short contact times.

Abstract: The invention comprises a seating plate including a concentric swivel leveler to be used for leveling a trailer on an uneven ground surface by inserting a connected trailer jack into the swivel and establishing a stationary position wherein the trailer is substantially level. In certain embodiments, a spacer is also provided with a receiving well for the swivel such that a height of the seating plate above the ground surface is increased such that the trailer jack need not be extended as far as it would but for the spacer. A spacer may be of durable material and includes reinforcing support members help support large loads. In certain embodiments, the swivel may be fastened to the spacer using nuts, bolts and the like so the swivel may swivel about the receiving well while the seating plate maintains a height above the space top to allow for the swiveling action.

Abstract: An aircraft includes a machine body that encloses a turbofan gas turbine engine and a plurality of ancillary systems. The turbofan gas turbine engine includes, in axial flow sequence, a first heat exchanger module, a fan assembly, a compressor module, a combustor module, a turbine module, and an exhaust module. The aircraft includes a second heat exchanger module. The machine body comprises a single fluid inlet aperture, with the fluid inlet aperture being configured to allow a fluid cooling flow to enter the machine body and to pass through the first heat exchanger module. When a temperature of the fluid cooling flow is less than a temperature of a fluid to be cooled, the fluid to be cooled is directed to the first heat exchanger module, and when a temperature of the fluid cooling flow is greater than a temperature of the fluid to be cooled, the fluid to be cooled is directed to the second heat exchanger module and cooled using a fuel supply for the gas turbine engine.

Abstract: Nucleic acid aptamers having a high binding affinity and specificity for malodorous molecules and the use of such aptamers to reduce the intensity of the undesirable smells in personal care compositions.

Abstract: Provided herein are compounds identified as inhibitors of KRAS protein activity that can be used to treat various diseases and disorders, such as cancer.

Abstract: In accordance with an embodiment, described herein is a system and method for delivery of content based on matching of user profiles with content metadata. The system enables delivery of personalized content, without the overhead of managing segment targeting rules, while providing content publishers or marketers with complete control over such personalization. A recommendation service or application program interface, provided by a computer, cloud computing environment, or other type of computer system, enables receipt and processing of requests, from client devices, for personalized content. A recommendation engine delivers content assets in response to a request from a client device. The recommendation engine determines a content channel and a user identity associated with the request, and then delivers content assets based on rules governing the matching of content asset metadata with the user profile. While content classification evolves over time, so also does the personalization of delivered content.

Abstract: A method for identifying documents that are similar in content to an input document includes receiving a request for identifying similar documents from among a plurality of candidate documents, retrieving document classification attributes for the input document and the candidate documents, where the document classification attributes are document level attributes.

Abstract: A fuel pump assembly comprises a plunger arranged to reciprocate within a plunger bore via a drive shaft, to perform a pumping cycle comprising a pumping stroke and a return stroke, the pumping stroke comprising movement of the plunger from a bottom dead centre (BDC) position to a top dead centre (TDC) position, and the return stroke comprising movement of the plunger from the TDC position to the BDC position. The fuel pump assembly comprises a spring assembly including a return spring that is cooperable, at a first end, with a first member coupled to the plunger and movable at a first speed dependent on the speed of rotation of the drive shaft and, at a second end, with a second member which is movable at a damped speed relative to the first speed.

Abstract: A software development infrastructure can enable user developers to select remote hardware devices to develop and test their software programs. For some tests and development activity, physical access to the remote device can be provided by the infrastructure administrator by replacing the internal calls of an application with mimic code, which can respond to application requests for sensor data, as if the user was physically handling the remote device at the same location.

Abstract: The present invention provides methods for predicting whether or not a test subject having primary biliary cholangitis (PBC) will benefit from advanced treatment in the form of a second-line agent used in addition to, or as an alternative to, ursodeoxycholic acid (UDCA). Associated methods for determining the therapeutic effect of a treatment regimen for PBC, methods for monitoring PBC progression, methods of PBC treatment, kits and assay devices are also provided.

Abstract: A turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, and a turbine module. The fan assembly comprises a plurality of fan blades defining a fan diameter (D). The heat exchanger module comprises a plurality of heat transfer elements. The heat exchanger module is in fluid communication with the fan assembly by an inlet duct. The inlet duct has a fluid path length along a central axis of the inlet duct between a downstream-most face of the heat transfer elements and an upstream-most face of the fan assembly. The fluid path length is less than 10.0*D.