Patents by Inventor David Knaack
David Knaack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11642435Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.Type: GrantFiled: October 30, 2019Date of Patent: May 9, 2023Assignee: Abyrx, Inc.Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
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Publication number: 20200061233Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.Type: ApplicationFiled: October 30, 2019Publication date: February 27, 2020Inventors: David KNAACK, John PACIFICO, Marci WIRTZ, Richard L. KRONENTHAL, Frank DO, Aniq DARR
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Patent number: 10549009Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.Type: GrantFiled: August 7, 2018Date of Patent: February 4, 2020Assignee: Abyrx, Inc.Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
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Patent number: 10517985Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.Type: GrantFiled: August 7, 2018Date of Patent: December 31, 2019Assignee: Abyrx, Inc.Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
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Patent number: 10328179Abstract: An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.Type: GrantFiled: March 18, 2015Date of Patent: June 25, 2019Assignee: Warsaw Orthopedic, Inc.Inventors: Keyvan Behnam, David Knaack
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Patent number: 10322209Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: GrantFiled: May 8, 2018Date of Patent: June 18, 2019Assignee: Warsaw Orthopedic, Inc.Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd Boyce, Lawrence A. Shimp
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Publication number: 20180361014Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.Type: ApplicationFiled: August 7, 2018Publication date: December 20, 2018Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
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Publication number: 20180344893Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.Type: ApplicationFiled: August 7, 2018Publication date: December 6, 2018Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
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Patent number: 10080661Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.Type: GrantFiled: May 9, 2016Date of Patent: September 25, 2018Assignee: Warsaw Orthopedic, Inc.Inventors: Deger C. Tunc, John Winterbottom, David R. Kaes, Todd Boyce, David Knaack, James Russell, Subhabrata Bhattacharyya
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Publication number: 20180250442Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: ApplicationFiled: May 8, 2018Publication date: September 6, 2018Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd Boyce, Lawrence A. Shimp
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Patent number: 9993579Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: GrantFiled: July 6, 2017Date of Patent: June 12, 2018Assignee: Warsaw Orthopedic, Inc.Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
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Publication number: 20170304496Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: ApplicationFiled: July 6, 2017Publication date: October 26, 2017Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
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Patent number: 9789223Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: GrantFiled: May 2, 2016Date of Patent: October 17, 2017Assignee: Warsaw Orthopedic, Inc.Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
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Publication number: 20160250025Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.Type: ApplicationFiled: May 9, 2016Publication date: September 1, 2016Inventors: Deger C. Tunc, John Winterbottom, David R. Kaes, Todd Boyce, David Knaack, James Russell, Subhabrata Bhattacharyya
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Publication number: 20160243284Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: ApplicationFiled: May 2, 2016Publication date: August 25, 2016Inventors: David Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
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Patent number: 9333080Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.Type: GrantFiled: August 21, 2013Date of Patent: May 10, 2016Assignee: Warsaw Orthopedic, Inc.Inventors: Deger C. Tunc, John Winterbottom, David R. Kaes, Todd M. Boyce, David Knaack, James Russell, Subhabrata Bhattacharyya
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Patent number: 9327052Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: GrantFiled: April 22, 2013Date of Patent: May 3, 2016Assignee: Warsaw Orthopedic, Inc.Inventors: David A. Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
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Patent number: 9107751Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.Type: GrantFiled: January 19, 2007Date of Patent: August 18, 2015Assignee: Warsaw Orthopedic, Inc.Inventors: John Winterbottom, David R. Kaes, Deger C. Tunc, Todd M. Boyce, David Knaack, James Russell, Subhabrata Bhattacharyya
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Publication number: 20150190547Abstract: An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.Type: ApplicationFiled: March 18, 2015Publication date: July 9, 2015Inventors: Keyvan Behnam, David Knaack
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Publication number: 20140275287Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for use in tamponade hemostasis of bone or cartilage.Type: ApplicationFiled: November 1, 2012Publication date: September 18, 2014Applicant: ABYRX, INC.Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr