Patents by Inventor David Knaack
David Knaack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8771719Abstract: A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.Type: GrantFiled: August 12, 2003Date of Patent: July 8, 2014Assignee: Warsaw Orthopedic, Inc.Inventors: Lawrence A. Shimp, John M. Winterbottom, Todd M. Boyce, David Knaack
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Patent number: 8740987Abstract: An implant including a substantially cohesive aggregate comprising bone-derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.Type: GrantFiled: December 20, 2004Date of Patent: June 3, 2014Assignee: Warsaw Orthopedic, Inc.Inventors: Perry Geremakis, Jennifer Grasso, David Knaack, Jo-Wen Lin, Lawrence Shimp, Robert Waterman, John Winterbottom
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Publication number: 20140121781Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.Type: ApplicationFiled: August 21, 2013Publication date: May 1, 2014Applicant: WARSAW ORTHOPEDIC, INC.Inventors: Deger C. Tunc, John Winterbottom, David R. Kaes, Todd M. Boyce, David Knaack, James Russell, Subhabrata Bhattacharyya
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Patent number: 8686064Abstract: The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.Type: GrantFiled: September 18, 2007Date of Patent: April 1, 2014Assignee: Warsaw Orthopedic, Inc.Inventors: Lawrence A. Shimp, David Knaack
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Publication number: 20140066523Abstract: The invention provides moldable drug delivery carriers made up of a suspension of a solid phase and an organic liquid phase for the sustained release of a therapeutic agent. The invention also provides multiphase drug delivery systems made up of a granular hydrophobic solid phase, an organic liquid phase and a hydrogel, for sustained drug delivery at varying rates over the life of the composition.Type: ApplicationFiled: May 1, 2012Publication date: March 6, 2014Applicant: ABYRX, Inc.Inventors: David Knaack, Ankur Gandhi, Jordan Katz, Marci Wirtz, Richard L. Kronenthal
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Patent number: 8545864Abstract: The present invention provides a hemostatic bone graft product and method. Hemostatic bone grafts may include demineralized bone matrix in combination with additives. In one embodiment, the graft comprises demineralized bone and polyethylene glycol. Methods for producing the hemostatic bone graft may include mixing demineralized bone with additives to facilitate protein precipitation, surface tension reduction in blood, and/or a cytolytic effect on cells at a bleeding site.Type: GrantFiled: July 5, 2007Date of Patent: October 1, 2013Assignee: Warsaw Orthopedic, Inc.Inventors: John W. Morris, David A. Knaack, Lawrence A. Shimp, Keyvan Behnam, Robert P. Skinner, Randal R. Betz
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Publication number: 20130236547Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: ApplicationFiled: April 22, 2013Publication date: September 12, 2013Applicant: Warsaw Orthopedic, Inc. Orthopedic, Inc.Inventors: David A. Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
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Patent number: 8425893Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: GrantFiled: July 13, 2011Date of Patent: April 23, 2013Assignee: Warsaw Orthopedic, Inc.Inventors: David A. Knaack, John Winterbottom, David R. Kaes, Todd M. Boyce, Lawrence A. Shimp
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Patent number: 8333985Abstract: A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol or hydrogels.Type: GrantFiled: January 27, 2005Date of Patent: December 18, 2012Assignee: Warsaw Orthopedic, Inc.Inventors: David Knaack, Michele Diegmann, Albert Manrique, Keyvan Benham
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Publication number: 20110268782Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: ApplicationFiled: July 13, 2011Publication date: November 3, 2011Applicant: WARSAW ORTHOPEDIC, INC.Inventors: David Knaack, John Winterbottom, David Kaes, Todd Boyce, Lawrence A. Shimp
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Patent number: 8002843Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: GrantFiled: February 4, 2004Date of Patent: August 23, 2011Assignee: Warsaw Orthopedic, Inc.Inventors: David Knaack, John Winterbottom, David Kaes, Todd Boyce, Lawrence A. Shimp
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Patent number: 7985414Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: GrantFiled: January 19, 2006Date of Patent: July 26, 2011Assignee: Warsaw Orthopedic, Inc.Inventors: David Knaack, John Winterbottom, David Kaes, Todd Boyce, Larry Shimp
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Patent number: 7959941Abstract: An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-.beta., BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.Type: GrantFiled: January 12, 2007Date of Patent: June 14, 2011Assignee: Warsaw Orthopedic, Inc.Inventors: David Knaack, Kathy Traianedes, Michele Diegman, Nanette Forsyth, John Winterbottom
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Publication number: 20080145392Abstract: An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-.beta., BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells.Type: ApplicationFiled: January 12, 2007Publication date: June 19, 2008Inventors: David Knaack, Kathy Traianedes, Michele Diegman, Nanette Forsyth, John Winterbottom
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Publication number: 20080063671Abstract: The present invention provides a hemostatic bone graft product and method. Hemostatic bone grafts may include demineralized bone matrix in combination with additives. In one embodiment, the graft comprises demineralized bone and polyethylene glycol. Methods for producing the hemostatic bone graft may include mixing demineralized bone with additives to facilitate protein precipitation, surface tension reduction in blood, and/or a cytolytic effect on cells at a bleeding site.Type: ApplicationFiled: July 5, 2007Publication date: March 13, 2008Inventors: John Morris, David Knaack, Lawrence Shimp, Keyvan Behnam, Robert Skinner, Randal Betz
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Publication number: 20080009955Abstract: The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.Type: ApplicationFiled: September 18, 2007Publication date: January 10, 2008Applicant: Osteotech, Inc.Inventors: Lawrence Shimp, David Knaack
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Patent number: 7270813Abstract: The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.Type: GrantFiled: October 8, 2003Date of Patent: September 18, 2007Assignee: Osteotech, Inc.Inventors: Lawrence A. Shimp, David Knaack
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Publication number: 20070191963Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.Type: ApplicationFiled: January 19, 2007Publication date: August 16, 2007Inventors: John Winterbottom, David Kaes, Deger Tunc, Todd Boyce, David Knaack, James Russell, Subhabrata Bhattacharyya
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Publication number: 20070178158Abstract: A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol, hydrogels, etc. The invention also provides methods of preparing, testing, and using the inventive stabilized osteodinductive matrix compositions.Type: ApplicationFiled: January 27, 2005Publication date: August 2, 2007Inventors: David Knaack, Michele Diegmann, Albert Manrique
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Patent number: 7163691Abstract: An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-?, BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.Type: GrantFiled: October 15, 2002Date of Patent: January 16, 2007Assignee: Osteotech, Inc.Inventors: David Knaack, Kathy Traianedes, Michele Diegman, Nanette Forsyth, John Winterbottom