Abstract: A method for obtaining diagnostic information about a region of a living being, the region having a medical device with a radiopaque portion disposed therein. An X-ray beam having a first energy level in excess of the K-absorption edge of the radiopaque portion of the medical device is directed at the region to obtain a first image information and radiographically locate the medical device within the living being and an X-ray beam having second energy level at or below the K-absorption edge is applied to the region to obtain a second image information.

Abstract: A digital list mode multichannel analyzer (MCA) built around a programmable FPGA device for onboard data analysis and on-the-fly modification of system detection/operating parameters, and capable of collecting and processing data in very small time bins (<1 millisecond) when used in histogramming mode, or in list mode as a list mode MCA,.

Abstract: A system for sensing light transmitted with reduced optical aberrations into the interior of an enclosure utilizing a liquid filled cavity. A window is disposed on the exterior surface of the enclosure for allowing light to pass into the enclosure. A lens is disposed on the interior side of the window, defining a cavity between the window and the lens. A fluid is disposed within that cavity. An optical sensor is disposed in the interior of the enclosure, and positioned to receive light through the window and the lens. The exterior surface of the window is shaped to conform to the exterior surface of the enclosure. The fluid is selected for having an index of refraction that minimizes the mismatch with the index of refraction of the window.

Abstract: A method for generating timing constraint systems, where the constrained object is a digital circuit., is provided, where the constraints are generated for the use of a digital logic optimization (synthesis) tool. The synthesis tool is used to optimize the circuit, under the applied constraints, so that the circuit exhibits certain desirable timing properties, while at the same time minimizing hardware cost and various other properties. The particular class of timing constraints generated by the disclosed invention is useful when the circuit is to be retimed after optimization. Typically, the joint use of the described invention and retiming results in improvements in the overall cost/performance tradeoff curve of the design.

Abstract: A communication system, clock recovery circuit, and method are provided for allowing data to be transmitted across a communication system and between clock recovery circuits absent a clock master specifically designed for one node of the communication system. Absent a clock master, the communication system is permitted to enter into an all slave mode, with periodic unlock conditions possibly rotating about the communication system ring topology. However, the unlock condition can be readily detected and if the received data bitstream formed into a recovered clock exceeds a threshold above or is less than a threshold below a reference clock generated during instances of unlock, then the clock recovery circuit will fix the synchronizing clock to the reference clock, and cause the bitstream to resynchronize to the reference clock before the reference clock is again disabled to allow the communication system to re-enter the all slave and rotating unlock condition.

Abstract: A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently mixing the solution (e.g., by vigorously stirring the solution) to produce the S-nitrosylated species; and (c) isolating the S-nitrosylated species. The nitrite-bearing species can be, for example, an inorganic nitrite, such as an alkali metal nitrite, or an organic nitrite, such as an alkyl nitrite (e.g., ethyl nitrite, amyl nitrite, isobutyl nitrite or t-butyl nitrite). The thiol is preferably a thiol-containing polysaccharide, a thiol-containing lipoprotein, a thiol-containing amino acid or a thiol-containing protein, and more preferably a thiol-containing polysaccharide such as thiolated cyclodextrin. In many preferred embodiments, the S-nitrosylated species is insoluble in the acidified solution, precipitating upon formation.

Abstract: An optical system includes a window having a nonspherically curved outer surface and a curved inner surface, and a transmission optical corrector adjacent to the curved inner surface of the window. The transmission optical corrector has a selectively nonuniform passive transmission optical property, such as a spatially varying index of refraction of the transmission optical corrector or a spatially varying diffractive property of the transmission optical corrector. The optical system further has an optical train positioned such that the transmission optical corrector lies between the curved window and the optical train. A sensor is disposed to receive the optical ray passing sequentially through the window, the transmission optical corrector, and the optical train.

Abstract: A portable radioactive-material detection system capable of detecting radioactive sources moving at high speeds. The system has at least one radiation detector capable of detecting gamma-radiation and coupled to an MCA capable of collecting spectral data in very small time bins of less than about 150 msec. A computer processor is connected to the MCA for determining from the spectral data if a triggering event has occurred. Spectral data is stored on a data storage device, and a power source supplies power to the detection system. Various configurations of the detection system may be adaptably arranged for various radiation detection scenarios. In a preferred embodiment, the computer processor operates as a server which receives spectral data from other networked detection systems, and communicates the collected data to a central data reporting system.

Abstract: This invention relates to devices and methods for the local, differential delivery of nitric oxide within the body. The devices include devices having at least two differing nitric oxide donor compounds, such as nitric oxide donor compounds having differing half-lives and nitric oxide donor compounds having different release mechanisms. The devices also include devices having at least two chemically distinct compositions to which nitric oxide donor compounds are adsorbed or attached or within which the donor compounds are disposed. The devices are typically used to increase local nitric oxide concentration in the body upon placement of the medical article at a delivery position on or within a patient.

Abstract: A business-to-business application service provider includes an Internet website and webserver with EDA-on-demand solutions for system-on-a-chip designers. Such website allows electronic designs in hardware description language to be uploaded into a front-end EDA design environment. A behavioral model simulation tool hosted privately on the webserver tests and validates the design. Such tool executes only in the secure environment of the business-to-business application service provider. The validated solution is then downloaded back over the Internet for a pay-per-use fee to the customer, and in a form ready to be placed and routed by a back-end EDA tool. Such validated design solutions are also downloadable to others in exchange for other designs, or available in technology libraries. The intellectual property created can be re-used, sold, shared, exchanged, and otherwise distributed efficiently and easily from a central for-profit clearinghouse.

Abstract: A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently mixing the solution (e.g., by vigorously stirring the solution) to produce the S-nitrosylated species; and (c) isolating the S-nitrosylated species. The nitrite-bearing species can be, for example, an inorganic nitrite, such as an alkali metal nitrite, or an organic nitrite, such as an alkyl nitrite (e.g., ethyl nitrite, amyl nitrite, isobutyl nitrite or t-butyl nitrite). The thiol is preferably a thiol-containing polysaccharide, a thiol-containing lipoprotein, a thiol-containing amino acid or a thiol-containing protein, and more preferably a thiol-containing polysaccharide such as thiolated cyclodextrin. In many preferred embodiments, the S-nitrosylated species is insoluble in the acidified solution, precipitating upon formation.

Abstract: This invention relates to devices and methods for the local, differential delivery of nitric oxide within the body. The devices include devices having at least two differing nitric oxide donor compounds, such as nitric oxide donor compounds having differing half-lives and nitric oxide donor compounds having different release mechanisms. The devices also include devices having at least two chemically distinct compositions to which nitric oxide donor compounds are adsorbed or attached or within which the donor compounds are disposed. The devices are typically used to increase local nitric oxide concentration in the body upon placement of the medical article at a delivery position on or within a patient.

Abstract: A method for obtaining diagnostic information about a region of a living being, the region having a medical device with a radiopaque portion disposed therein. An X-ray beam having a first energy level in excess of the K-absorption edge of the radiopaque portion of the medical device is directed at the region to obtain a first image information and radiographically locate the medical device within the living being and an X-ray beam having second energy level at or below the K-absorption edge is applied to the region to obtain a second image information.

Abstract: A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently mixing the solution (e.g., by vigorously stirring the solution) to produce the S-nitrosylated species; and (c) isolating the S-nitrosylated species. The nitrite-bearing species can be, for example, an inorganic nitrite, such as an alkali metal nitrite, or an organic nitrite, such as an alkyl nitrite (e.g., ethyl nitrite, amyl nitrite, isobutyl nitrite or t-butyl nitrite). The thiol is preferably a thiol-containing polysaccharide, a thiol-containing lipoprotein, a thiol-containing amino acid or a thiol-containing protein, and more preferably a thiol-containing polysaccharide such as thiolated cyclodextrin. In many preferred embodiments, the S-nitrosylated species is insoluble in the acidified solution, precipitating upon formation.

Abstract: Embolic polymer particles are described.

Abstract: A wall mountable assembly such as a wall mountable towel ring or the like includes a base part and an object support part extending from the base part. The base part is formed from a wall attachment member and a cover member which fits over the wall attachment member. The wall attachment member has an arm which extends through the cover member and which secures by a pivot connection to a cam member at the inner end of the object support part of the assembly. The object support part is swingable from a non-use to a use position relative to the base part to cause the cam member to move between a loose and a tight fitting with respect to the cover of the base part. The assembly further includes a locking member which releasably secures to the cam member and which blocks the cam member from moving away from the tight fitting holding all of the components of the assembly tightly secured to one another.

Abstract: A blanket of fibrous building insulation is provided, for in situ cutting to correspond to spacings between studs or like building members between which the insulation is to be applied. The blanket includes a layer of fibrous insulation material and a facing material adhered thereto. An adhesive provides the adhesion between the two layers. Perforations in the facing material provide openings allowing some of the adhesive to bleed into the perforations to be visible from the opposite side whereby a plurality of perforations provide guidelines for cutting the blanket to desired sizes for installation between structural building members.

Abstract: A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the activator compound interacts with the precursor compound and converts the precursor compound into activated form for local delivery. Specific examples of precursor and activator compound pairs include: (a) a nitrosothiol precursor and a nitric oxide donor, (b) plasminogen and plasminogen activator, and (c) fibrinogen and thrombin.