Patents by Inventor David L. Brown

David L. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for mitigating the production of water from subterranean formations
    Patent number: 7345011
    Abstract: The present invention relates to treatment operations in subterranean zones, and more particularly, to consolidation compositions and methods of using these consolidation compositions to mitigate water production from subterranean formations. The present invention provides methods for mitigating the production of water from a subterranean formation by injecting consolidation compositions comprising a furan-based resin into an interval in the subterranean formation.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: March 18, 2008
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Philip D. Nguyen, David L. Brown, Bhadra D. Desai
  • 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines
    Patent number: 7338965
    Abstract: The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. One embodiment of the invention relates to compounds having the structure: where Z is CR or N, and R1, R2 and R3 are as described in the specification.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: March 4, 2008
    Assignees: Pharmacia & Upjohn Company, Elan Pharmaceuticals, Inc.
    Inventors: Joseph B. Moon, Shon R. Pulley, Daniel H. Rich, David L. Brown, Barbara Jagodzinska, Varghese John, John Jacobs
  • Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 7339078
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: March 4, 2008
    Assignee: G.D. Searle LLC
    Inventors: Daniel P Getman, Gary A DeCrescenzo, John N Freskos, Michael L Vazquez, James A Sikorski, Balekudru Devadas, Srinivasan Raj Nagarajan, David L Brown, Joseph J McDonald
  • Power generation utilizing tire pressure changes
    Patent number: 7260984
    Abstract: A method of powering one or more electronic devices in a tire monitoring system using a tire pressure based energy scavenger is provided. With this method, a tire is rotated on a surface to generate pressure changes within the tire. These pressure changes are then converted into electrical energy with a transducer and the energy is stored. The electrical energy or stored electrical energy can then be used to power one or more electronic devices in a tire monitoring system, such as a tire pressure sensor, temperature sensor, acceleration profile sensor, and/or a tire wear monitor. A tire monitoring system with a tire pressure based energy scavenger is also provided.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: August 28, 2007
    Assignee: LV Sensors, Inc.
    Inventors: Shad Roundy, Janusz Bryzek, Curtis Ray, Michael Malaga, David L. Brown
  • Automatic on/off switch for vehicle power outlets
    Patent number: 7248152
    Abstract: A vehicle power outlet switch (10) can include a threshold detector (14) for comparing a predetermined threshold with a vehicle battery characteristic and a power switch (18) controlled by the output of the threshold detector. Note, the vehicle battery characteristic differs while the vehicle engine is turned on or turned off and the threshold detector provides an enabling signal to the power switch when the vehicle engine is detected as being on. The threshold detector can also provide a disabling signal to the power switch when the vehicle engine is off. The power outlet switch can further include a timer (16) coupled to an output of the threshold detector that continues to provide an enabling signal to the power switch for a predetermined time after the threshold detector detects that the vehicle engine is turned off. The timer can include or be a one shot timer.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: July 24, 2007
    Assignee: XM Satellite Radio, Inc.
    Inventors: Jason Gilbert, David L. Brown
  • Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 7161033
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: January 9, 2007
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Raj Nagarajan, David L. Brown, Joseph J. McDonald
  • Hydroxy alkyl amines
    Patent number: 7144897
    Abstract: Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compounds of formula X are also disclosed.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: December 5, 2006
    Assignees: Elan Oharmaceuticals, Inc., Pharmacia & Upjohn, Co.
    Inventors: John Freskos, David L. Brown, Yvette M. Fobian, Larry Fang, Arthur Glenn Romero, Varghese John
  • Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 7141594
    Abstract: Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: November 28, 2006
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L. Brown, Joseph J. McDonald
  • Substituted benzopyran derivatives for the treatment of inflammation
    Patent number: 7138411
    Abstract: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I? wherein X, A1, A2, A3, A4, R, R?, R1 and R2 are as described in the specification.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: November 21, 2006
    Assignee: G.D. Searle & Co.
    Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier, Jr., Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte
  • Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
    Patent number: 7119203
    Abstract: This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: October 10, 2006
    Assignee: Pharmacia Corporation
    Inventors: Thomas E. Barta, Daniel P. Becker, Louis J. Bedell, Terri L. Boehm, David L. Brown, Jeffery N. Carroll, Yiyuan Chen, Yvette M. Fobian, John N. Freskos, Alan F. Gasiecki, Margaret L. Grapperhaus, Robert M. Heintz, Susan L. Hockerman, Darren J. Kassab, Ish K. Khanna, Stephen A. Kolodziej, Mark A. Massa, Joseph J. McDonald, Brent V. Mischke, Deborah A. Mischke, Patrick B. Mullins, Mark A. Nagy, Monica B. Norton, Joseph G. Rico, Michelle A. Schmidt, Nathan W. Stehle, John J. Talley, William F. Vernier, Clara I. Villamil, Lijuan J. Wang, Thomas A. Wynn
  • Substituted benzopyran derivatives for the treatment of inflammation
    Patent number: 7109211
    Abstract: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I? wherein X, A1, A2, A3, A4, R, R?, R1 and R2 are as described in the specification.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: September 19, 2006
    Assignee: Pharmacia Corporation (of Pfizer, Inc.)
    Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J. Rogier, Jr., Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte
  • Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 7098202
    Abstract: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: August 29, 2006
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L. Brown, Joseph J. McDonald
  • Methods for controlling water and particulate production
    Patent number: 7028774
    Abstract: The present invention provides methods of reducing the production of both water and particulates from subterranean formations; the methods are particularly useful in conjunction with subterranean formations surrounding wellbores and fractures. The methods comprise the steps of applying to a subterranean formation a pre-flush fluid, applying aqueous surfactant fluid, applying a low-viscosity consolidating fluid, and applying an after-flush fluid.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: April 18, 2006
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Philip D. Nguyen, David L. Brown
  • Methods and compositions for sealing oil containing subterranean zones
    Patent number: 7026272
    Abstract: The present invention provides methods and compositions for sealing subterranean zones containing oil to prevent the uncontrolled flow of fluids into or from the zones. The compositions basically comprise water, a phosphonic acid ester, a multivalent metal ion releasing compound and an organophilic clay.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: April 11, 2006
    Assignee: Halliburton Energy Services, Inc.
    Inventors: B. Raghava Reddy, Gary P. Funkhouser, David L. Brown
  • Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
    Patent number: 6998415
    Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: February 14, 2006
    Assignee: Pharmacia Corporation
    Inventors: John J. Talley, James A. Sikorski, Balekudru Devadas, Matthew J. Graneto, Jeffery S. Carter, Bryan H. Norman, Kathy L. Rogers, legal representative, Hwang-Fun Lu, David L. Brown, Roland S. Rogers, deceased
  • Methods for controlling water and particulate production
    Patent number: 6978836
    Abstract: The present invention provides methods of reducing the production of both water and particulates from subterranean formations; the methods are particularly useful in conjunction with subterranean formations surrounding wellbores and fractures. The methods comprise the steps of applying to a subterranean formation a pre-flush fluid, applying aqueous surfactant fluid, applying a low-viscosity consolidating fluid, and applying an after-flush fluid.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: December 27, 2005
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Philip D. Nguyen, David L. Brown
  • Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 6861539
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: March 1, 2005
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P Getman, Gary A DeCrescenzo, John N Freskos, Michael L Vazquez, James A Sikorski, Balekudru Devadas, Srinivasan Raj Nagarajan, David L Brown, Joseph J McDonald
  • Wound stator core and method of making
    Patent number: 6851175
    Abstract: A method of inserting coils in slots of a stator is provided. The method includes interleaving a first set of first phase windings and a first set of second phase windings on an insertion tool. The method also includes activating the insertion tool to radially insert the first set of first phase windings and the first set of second phase windings in the slots of the stator. In one embodiment, interleaving the first set of first phase windings and the first set of second phase windings on the insertion tool includes forming the first set of first phase windings in first phase openings defined in the insertion tool, and forming the first set of second phase windings in second phase openings defined in the insertion tool.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: February 8, 2005
    Assignee: Delphi Technologies, Inc.
    Inventors: David L Brown, Gerald R Stabel, Robert Anthony Lawrence
  • Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Publication number: 20040260095
    Abstract: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: January 20, 2004
    Publication date: December 23, 2004
    Applicant: G. D. Searle & Co.
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L. Brown, Joseph J. McDonald
  • Methods for controlling water and particulate production
    Publication number: 20040231847
    Abstract: The present invention provides methods of reducing the production of both water and particulates from subterranean formations; the methods are particularly useful in conjunction with subterranean formations surrounding wellbores and fractures. The methods comprise the steps of applying to a subterranean formation a pre-flush fluid, applying aqueous surfactant fluid, applying a low-viscosity consolidating fluid, and applying an after-flush fluid.
    Type: Application
    Filed: May 23, 2003
    Publication date: November 25, 2004
    Inventors: Philip D. Nguyen, David L. Brown