Patents by Inventor David L. Brown

David L. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Publication number: 20020111368
    Abstract: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: April 18, 2001
    Publication date: August 15, 2002
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L. Brown, Joseph J. McDonald
  • Methods and compositions for forming permeable cement sand screens in well bores
    Publication number: 20020108535
    Abstract: Methods and compositions for forming permeable cement sand screens in well bores are provided. The compositions are basically comprised of a hydraulic cement, a particulate cross-linked gel containing an internal breaker which after time causes the gel to break into a liquid and water present in an amount sufficient to form a slurry.
    Type: Application
    Filed: February 19, 2002
    Publication date: August 15, 2002
    Inventors: Philip D. Nguyen, Ronald J. Crook, Johnny A. Barton, David L. Brown
  • Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
    Publication number: 20020086886
    Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lizoxygenase, such as inflammation.
    Type: Application
    Filed: December 4, 2001
    Publication date: July 4, 2002
    Applicant: G.D. Searle & Co.
    Inventors: John J. Talley, James A. Sikorski, Balekudru Devadas, Matthew J. Graneto, Jeffery S. Carter, Bryan H. Norman, Roland S. Rogers, Kathy L. Rogers, Hwang-Fun Lu, David L. Brown
  • Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 6407134
    Abstract: Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: June 18, 2002
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P Getman, Gary A DeCrescenzo, John N Freskos, Michael L Vazquez, James A Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L Brown, Joseph J McDonald
  • Method and apparatus for dispatch communications in a broadcast radio system
    Patent number: 6397076
    Abstract: A method and apparatus for receiving dispatch messages in a broadcast radio receiver. In one embodiment, audio dispatch messages can be received, in another embodiment, data dispatch messages can be received. In either embodiment, a previously selected broadcast channel is received until a dispatch alert message is simultaneously received. The dispatch alert message includes a dispatch ID codes which is compared by the receiver with a previously stored dispatch ID code. If equality is found, the receiver switches from the previously selected broadcast channel to a dispatch broadcast channel to receive the dispatch message. Upon completion of the dispatch message, the receiver automatically switches back to the previously selected broadcast channel.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: May 28, 2002
    Assignee: XM Satellite Radio, Inc.
    Inventors: David L. Brown, Craig Wadin
  • Methods and compositions for forming permeable cement sand screens in well bores
    Patent number: 6390195
    Abstract: Methods and compositions for forming permeable cement sand screens in well bores are provided. The compositions are basically comprised of a hydraulic cement, a particulate cross-linked gel containing an internal breaker which after time causes the gel to break into a liquid and water present in an amount sufficient to form a slurry.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: May 21, 2002
    Assignee: Halliburton Energy Service,s Inc.
    Inventors: Philip D. Nguyen, Ronald J. Crook, Johnny A. Barton, David L. Brown
  • Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 6388132
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: May 14, 2002
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P Getman, Gary A DeCrescenzo, John N Freskos, Michael L Vazquez, James A Sikorski, Balekudru Devadas, Srinivasan Raj Nagarajan, David L Brown, Joseph J McDonald
  • Methods and compositions for forming permeable cement sand screens in well bores
    Patent number: 6364945
    Abstract: Methods and compositions for forming permeable cement sand screens in well bores are provided. The compositions are basically comprised of a hydraulic cement, an acid soluble particulate solid, a liquid hydrocarbon solvent soluble particulate solid, a particulate cross-linked gel containing an internal breaker which after time causes the gel to break into a liquid, water present in an amount sufficient to form a slurry, a gas present in an amount sufficient to form a foam and a mixture of foaming and foamed stabilizing surfactants.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: April 2, 2002
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Jiten Chatterji, Roger S. Cromwell, Baireddy R. Reddy, Bobby J. King, Philip D. Nguyen, David L. Brown
  • Methods of reducing the water permeability of subterranean formations
    Patent number: 6364016
    Abstract: Improved methods of treating water and hydrocarbons producing subterranean formations to reduce the water permeabilities of the formations without substantially reducing the hydrocarbons permeabilities thereof are provided. The methods basically comprise introducing into the formation a chemical which does not resist water flow and attaches to adsorption sites on surfaces within the porosity of the formation but slowly washes off the sites as another fluid flows through the treated formation. Thereafter, a water flow resisting polymer is introduced into the formation so that it flows deeply into the porosity of the formation before the previously introduced chemical washes off and attaches to the adsorption sites as the chemical washes off.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: April 2, 2002
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Eldon D. Dalrymple, Larry S. Eoff, Baireddy R. Reddy, David L. Brown, Paul S. Brown
  • Methods and compositions for forming permeable cement sand screens in well bores
    Publication number: 20020035951
    Abstract: Methods and compositions for forming permeable cement sand screens in well bores are provided. The compositions are basically comprised of a hydraulic cement, an acid soluble particulate solid, a liquid hydrocarbon solvent soluble particulate solid, a particulate cross-linked gel containing an internal breaker which after time causes the gel to break into a liquid, water present in an amount sufficient to form a slurry, a gas present in an amount sufficient to form a foam and a mixture of foaming and foamed stabilizing surfactants.
    Type: Application
    Filed: December 13, 2000
    Publication date: March 28, 2002
    Inventors: Jiten Chatterji, Roger S. Cromwell, Baireddy R. Reddy, Bobby J. King, Philip D. Nguyen, David L. Brown
  • Process for making substituted pyrazoles
    Patent number: 6342608
    Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: January 29, 2002
    Assignee: G.D. Searle & Company
    Inventors: Michael L. Vazquez, Susan J. Hartmann, Suzanne Metz, John J. Talley, David L. Brown, Richard M. Weier, Michael A. Stealey, Xiaodong Xu
  • Substituted benzopyran analogs for the treatment of inflammation
    Publication number: 20020010206
    Abstract: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders.
    Type: Application
    Filed: May 24, 2001
    Publication date: January 24, 2002
    Applicant: G.D. Searle & Co.
    Inventors: Jeffery S. Carter, Mark G. Obukowicz, Balekudru Devadas, John J. Talley, David L. Brown, Matthew J. Graneto, Stephen R. Bertenshaw, Donald J. Rogier,, Srinivasan Raj Nagarajan, Cathleen E. Hanau, Susan J. Hartmann, Cindy L. Ludwig, Suzanne Metz, Donald E. Korte
  • Jousting game
    Patent number: 6332616
    Abstract: Two playing pieces each include a body portion, a shield having at least two hinged segments attached to the body portion, a first control mechanism operable to select one of the hinged segments as a blocked segment, a projecting element attached to the body portion and having a raised position and at least two lowered positions, and a second control mechanism operable to select one of the lowered positions as an active position. The two playing pieces can be placed on a track structure at opposite respective ends for movement towards each other along respective paths of movement. In one possible outcome, the projecting element of one of the playing pieces strikes the blocked segment of the shield of the other playing piece and in another outcome the projecting element strikes an unblocked segment of the shield of the other playing piece.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: December 25, 2001
    Inventor: David L. Brown
  • Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 6316496
    Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: November 13, 2001
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P Getman, Gary A DeCrescenzo, John N Freskos, Michael L Vazquez, James A Sikorski, Balekudru Devadas, Srinivasan Raj Nagarajan, David L Brown, Joseph J McDonald
  • Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 6310080
    Abstract: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically inhibiting retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: October 30, 2001
    Assignee: G. D. Searle & Co.
    Inventors: Daniel P Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L. Brown, Joseph J. McDonald
  • Substituted benzopyran derivatives for the treatment of inflammation
    Patent number: 6271253
    Abstract: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: August 7, 2001
    Assignee: G.D. Searle & Co.
    Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier, Jr., Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte
  • Packaged synthetic absorbable surgical elements
    Patent number: 6260699
    Abstract: Synthetic absorbable sutures are filled with a stabilizing agent, preferably a mixture of glycerol and calcium lactate, and inserted into a retainer having a narrow convoluted passageway. The retainer is inserted into an open foil pouch with a package stabilizing element such as a paper sheet filled with stabilizing agent. The package containing the suture, retainer and package stabilizing element is sterilized, aerated, equilibrated to a relatively high moisture level, and sealed. Long lengths of suture and doubled-over and tripled-over suture may be withdrawn from the retainer with low force without damaging the suture. Bends and kinks in the suture are prevented so as to provide a synthetic absorbable suture having highly desirable out of package hand and feel. The suture an removed from the package exhibits improved tissue drag characteristics.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 17, 2001
    Assignee: United States Surgical Corporation
    Inventors: Donald S. Kaplan, Matthew E. Hermes, Ross R. Muth, David L. Brown, Henry A. Holzwarth
  • Process for making substituted pyrazoles
    Patent number: 6242612
    Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: June 5, 2001
    Assignee: G. D. Searle & Co.
    Inventors: Matthew J. Graneto, Michael L. Vazquez, Susan J. Hartmann, Suzanne Metz, John J. Talley, David L. Brown, Richard M. Weier, Michael A. Stealey, Xiangdong Xu
  • Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Patent number: 6214861
    Abstract: Selected heterocycle carbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Grant
    Filed: February 9, 2000
    Date of Patent: April 10, 2001
    Assignee: G.D. Searle & Co.
    Inventors: Daniel P Getman, Gary A DeCrescenzo, John N Freskos, Michael L Vazquez, James A Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L Brown, Joseph J McDonald
  • Methods and compositions for forming permeable cement sand screens in well bores
    Patent number: 6202751
    Abstract: Methods and compositions for forming permeable cement sand screens in well bores are provided. The compositions are basically comprised of a hydraulic cement, an acid soluble particulate solid, a liquid hydrocarbon solvent soluble particulate solid, a particulate cross-linked gel containing an internal breaker which after time causes the gel to break into a liquid, water present in an amount sufficient to form a slurry, a gas present in an amount sufficient to form a foam and a mixture of foaming and foamed stabilizing surfactants.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: March 20, 2001
    Assignee: Halliburton Energy Sevices, Inc.
    Inventors: Jiten Chatterji, Roger S. Cromwell, Baireddy R. Reddy, Bobby J. King, Philip D. Nguyen, David L. Brown