Patents by Inventor David Largaespada

David Largaespada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intracellular genomic transplant and methods of therapy
    Patent number: 11925664
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: March 12, 2024
    Assignees: INTIMA BIOSCIENCE, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Branden Moriarity, Beau Webber, David Largaespada, Modassir Choudhry, Steven A. Rosenberg
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
    Patent number: 11760983
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: September 19, 2023
    Assignee: B-Mogen Biotechnologies, Inc.
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • ENHANCED hAT FAMILY MEMBER SPIN TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
    Publication number: 20230272355
    Abstract: This disclosure provides various SPIN transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: June 4, 2021
    Publication date: August 31, 2023
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Bryan Jones
  • Modified cells and methods of therapy
    Patent number: 11583556
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: February 21, 2023
    Assignees: Regents of the University of Minnesota, Intima Bioscience, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, R. Scott McIvor, David Largaespada, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
    Publication number: 20220280569
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: March 10, 2022
    Publication date: September 8, 2022
    Inventors: David LARGAESPADA, Branden MORIARITY, Beau WEBBER, Neil OTTO, Sandeep KUMAR, Leah HOGDAL
  • MODIFIED CELLS AND METHODS OF THERAPY
    Publication number: 20220125843
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: September 17, 2021
    Publication date: April 28, 2022
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, R. Scott McIvor, David Largaespada, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • Enhanced hAT Family Transposon-Mediated Gene Transfer and Associated Compositions, Systems, and Methods
    Publication number: 20220112472
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: October 22, 2021
    Publication date: April 14, 2022
    Applicant: B-MoGen Biotechnologies, Inc.
    Inventors: David LARGAESPADA, Branden MORIARITY, Beau WEBBER, Neil OTTO, Sandeep KUMAR, Leah HOGDAL
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
    Patent number: 11278570
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: March 22, 2022
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
    Patent number: 11162084
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: November 2, 2021
    Assignee: B-MOGEN BIOTECHNOLOGIES, INC.
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • Modified cells and methods of therapy
    Patent number: 11147837
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: October 19, 2021
    Assignees: Regents of the University of Minnesota, Intima Bioscience, Inc., The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, R. Scott McIvor, David Largaespada, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
    Publication number: 20210277366
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: June 21, 2019
    Publication date: September 9, 2021
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems and methods
    Patent number: 11111483
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: September 7, 2021
    Assignee: B-MoGen Biotechnologies, Inc.
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • MODIFIED CELLS AND METHODS OF THERAPY
    Publication number: 20210260117
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: August 26, 2020
    Publication date: August 26, 2021
    Inventors: Branden MORIARITY, Beau WEBBER, Modassir CHOUDHRY, R. Scott MCIVOR, David LARGAESPADA, Steven A. ROSENBERG, Douglas C. PALMER, Nicholas P. RESTIFO
  • INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
    Publication number: 20200353001
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: June 12, 2020
    Publication date: November 12, 2020
    Inventors: Branden Moriarity, Beau Webber, David Largaespada, Modassir Choudhry, Steven A. Rosenberg
  • Enhanced hAT Family Transposon-Mediated Gene Transfer and Associated Compositions, Systems, and Methods
    Publication number: 20200339965
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: February 12, 2020
    Publication date: October 29, 2020
    Inventors: David LARGAESPADA, Branden MORIARITY, Beau WEBBER, Neil OTTO, Sandeep KUMAR, Leah HOGDAL
  • ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
    Publication number: 20200323902
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 15, 2020
    Inventors: David LARGAESPADA, Branden MORIARITY, Beau WEBBER, Neil OTTO, Sandeep KUMAR, Leah HOGDAL
  • INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
    Publication number: 20200306309
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Inventors: Branden Moriarity, Beau Webber, David Largaespada, Modassir Choudhry, Steven A. Rosenberg
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
    Patent number: 10227574
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: March 12, 2019
    Assignee: B-Mogen Biotechnologies, Inc.
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • VECTORS AND SYSTEM FOR MODULATING GENE EXPRESSION
    Publication number: 20190038780
    Abstract: A polynucleotide that modulates transcription from a plurality of genomic targets can include, generally, a polynucleotide encoding a gRNA array and a polynucleotide sequence encoding a nuclease-deficient Cas9 polypeptide. The polynucleotide encoding a gRNA array generally includes polynucleotides encoding at least two gRNAs operably linked to an inducible regulatory sequence.
    Type: Application
    Filed: February 3, 2017
    Publication date: February 7, 2019
    Inventors: David A. Largaespada, Branden S. Moriarity
  • ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
    Publication number: 20180327726
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: June 11, 2018
    Publication date: November 15, 2018
    Inventors: David LARGAESPADA, Branden MORIARITY, Beau WEBBER, Neil OTTO, Sandeep KUMAR, Leah HOGDAL