Patents by Inventor David Lauffer

David Lauffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIAZOLOTHIADIAZOLE INHIBITOR OF C-MET PROTEIN KINASE
    Publication number: 20110207774
    Abstract: The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1 and methods of using the compositions in the treatment of proliferative disorders.
    Type: Application
    Filed: May 3, 2011
    Publication date: August 25, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: David Lauffer, Pan Li, Dean Shannon, Jianglin Liang
  • Inhibitors of c-Met and uses thereof
    Patent number: 7998987
    Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: August 16, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Alex Aronov, Pan Li, David Deininger, Kira McGinty, Dean Stamos, Jon Come, Michelle Stewart
  • C-MET PROTEIN KINASE INHIBITORS
    Publication number: 20110136789
    Abstract: The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders.
    Type: Application
    Filed: March 31, 2010
    Publication date: June 9, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: David Lauffer, Pan Li, Nathan Waal, Kira Mcginty, Qing Tang, Steven Ronkin, Luc Farmer, Dean Shannon, Dylan Jacobs
  • AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTIEN KINASE
    Publication number: 20110124684
    Abstract: The present invention relates to compounds of formula I, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
    Type: Application
    Filed: May 27, 2010
    Publication date: May 26, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: David Lauffer, Pan Li, Kira McGinty
  • INHIBITORS OF C-MET PROTEIN KINASE
    Publication number: 20100305156
    Abstract: The present invention relates to compounds of formula I, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
    Type: Application
    Filed: May 27, 2010
    Publication date: December 2, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: David Lauffer, Pan Li
  • SUBSTITUTED PYRAZOLE INHIBITORS OF C-MET PROTEIN KINASE
    Publication number: 20100305155
    Abstract: The present invention relates to compounds of formula I, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
    Type: Application
    Filed: May 27, 2010
    Publication date: December 2, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Pan Li, Nathan Waal, Steven Ronkin, Qing Tang, David Lauffer
  • TRIAZOLOTHIADIAZOLE INHIBITOR OF C-MET PROTEIN KINASE
    Publication number: 20100234423
    Abstract: The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1 and methods of using the compositions in the treatment of proliferative disorders.
    Type: Application
    Filed: November 18, 2009
    Publication date: September 16, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: David Lauffer, Pan Li, Dean Shannon, Jianglin Liang
  • HETEROCYCLIC INHIBITORS OF C-MET AND USES THEREOF
    Publication number: 20100144739
    Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
    Type: Application
    Filed: September 18, 2007
    Publication date: June 10, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Alexander Aronov, Jon Come, John Court, David Deininger, David Lauffer, Pan Li, Kira McGinty, Suganthini Nanthakumar, Dean Stamos, Kirk Tanner
  • Azaindoles useful as inhibitors of JAK and other protein kinases
    Publication number: 20090176763
    Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: November 19, 2008
    Publication date: July 9, 2009
    Inventors: Francesco Salituro, Luc Farmer, Randy Bethiel, Edmund Harrington, Jeremy Green, John Court, Jon Come, David Lauffer, Alex Aronov, Hayley Binch, Dean Boyall, Jean-Damien Charrier, Simon Everitt, Damien Fraysse, Michael Mortimore, Francoise Pierard, Daniel Robinson, Jian Wang, Joanne Pinder, Tiansheng Wang, Albert Pierce
  • Azaindoles useful as inhibitors of JAK and other protein kinases
    Patent number: 7507826
    Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: March 24, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Francesco Salituro, Luc Farmer, Randy Bethiel, Edmund Harrington, Jeremy Green, John Court, Jon Come, David Lauffer, Alex Aronov, Hayley Binch, Dean Boyall, Jean-Damien Charrier, Simon Everitt, Damien Fraysse, Michael Mortimore, Francoise Pierard, Daniel Robinson, Jian Wang, Joanne Pinder, Tiansheng Wang, Albert Pierce
  • Inhibitors of interleukin-1 beta converting enzyme
    Publication number: 20080070953
    Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1? converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.
    Type: Application
    Filed: September 18, 2007
    Publication date: March 20, 2008
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Guy Bemis, Julian Golec, David Lauffer, Michael Mullican, Mark Murcko, David Livingston
  • Inhibitors of interleukin-1beta converting enzyme
    Publication number: 20080039449
    Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1? converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-?-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-?-mediated diseases and decreasing IGIF and IFN-? production using the compounds and compositions of this invention.
    Type: Application
    Filed: January 18, 2007
    Publication date: February 14, 2008
    Inventors: Mark Batchelor, David Bebbington, Guy Bemis, Wolf Fridman, Roger Gillespie, Julian Golec, David Lauffer, David Livingston, Saroop Matharu, Michael Mullican, Mark Murcko, Robert Murdoch, Robert Zelle
  • C-MET protein kinase inhibitors
    Publication number: 20070254868
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 21, 2007
    Publication date: November 1, 2007
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Robert Davies, Dean Stamos, Alexander Aronov, David Deininger, Ronald Grey, Jinwang Xu, Pan Li, Brian Ledford, Luc Farmer, Randy Bethiel, Dylan Jacobs, Kira McGinty
  • Deazapurines useful as inhibitors of Janus kinases
    Publication number: 20070207995
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: September 28, 2006
    Publication date: September 6, 2007
    Inventors: Francesco Salituro, Luc Farmer, Tiansheng Wang, Jian Wang, Randy Bethiel, Marion Wannamaker, Gabriel Martinez-Botella, John Duffy, Alexander Aronov, David Lauffer, Albert Pierce
  • Inhibitors of c-Met and uses thereof
    Publication number: 20070191369
    Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
    Type: Application
    Filed: November 30, 2006
    Publication date: August 16, 2007
    Inventors: David Lauffer, Alexander Aronov, Pan Li, David Deininger, Kira McGinty, Dean Stamos, Jon Come, Michelle Stewart
  • Azaindoles useful as inhibitors of JAK and other protein kinases
    Publication number: 20070043063
    Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 30, 2005
    Publication date: February 22, 2007
    Inventors: Francesco Salituro, Luc Farmer, Randy Bethiel, Edmund Harrington, Jeremy Green, John Court, Jon Come, David Lauffer, Alex Aronov, Hayley Binch, Dean Boyall, Jean-Damien Charrier, Simon Everitt, Damien Fraysse, Michael Mortimore, Francoise Pierard, Daniel Robinson, Jian Wang, Joanne Pinder, Tiansheng Wang
  • Acyclic and cyclic amine derivatives
    Patent number: 7105546
    Abstract: The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: September 12, 2006
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Mullican, David Lauffer, Roger Tung
  • Pyrrole compounds useful as kinase inhibitors
    Publication number: 20060173055
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: March 22, 2006
    Publication date: August 3, 2006
    Inventors: Alex Aronov, Upul Bandarage, David Lauffer, Pan Li, Ronald Tomlinson
  • Acyclic piperidine derivatives
    Patent number: 6949655
    Abstract: A compound having the formula (I): wherein: each R1, R2, R3 and R4 are independently selected from (C1-C10)-straight or branched alkyl, Ar-substituted- (C1-C10)-straight or branched alkyl, (C2-C10)-straight or branched alkenyl or alkynyl, or Ar-substituted-(C2-C10)-straight or branched alkenyl or alkynyl; wherein one to two CH2 groups of said alkyl, alkenyl, or alkynyl chains in each of R1, R2, R3 and R4 are optionally and independently replaced with O, S, S(O), S(O), S(O)2, C(O) or N(R5) in a chemically stable arrangement, wherein the CH2 group of R1 and R2 bound directly to said nitrogen cannot be replaced with C(O); or R1 and R2 taken together form a 4 to 7 membered ring; or R3 and R4 taken together form a 3 to 7 membered ring; wherein a CH2 in either the R1 and R2 ring system or the R3 and R4 ring system is independently and optionally replaced with O, C(O), N(R5), S, S(O), S(O)2 in a chemically stable arrangement; or wherein either or both of the R1 and R2 ring system and the R3 and R4 ring sy
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: September 27, 2005
    Inventors: David Lauffer, Ronald Tomlinson, Eckhard Ottow, Martyn Botfield
  • Imidazole compositions useful as inhibitors of protein kinases
    Publication number: 20050148574
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 24, 2004
    Publication date: July 7, 2005
    Inventors: Alex Aronov, David Lauffer, Pan Li, Ronald Tomlinson