Patents by Inventor David Lauffer

David Lauffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of interleukin-1beta converting enzyme
    Publication number: 20050143436
    Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1? converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-?-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-?-mediated diseases and decreasing IGIF and IFN-? production using the compounds and compositions of this invention.
    Type: Application
    Filed: November 29, 2004
    Publication date: June 30, 2005
    Inventors: Mark Batchelor, David Bebbington, Guy Bemis, Wolf Fridman, Roger Gillespie, Julian Golec, David Lauffer, David Livingston, Saroop Matharu, Michael Mullican, Mark Murcko, Robert Murdoch, Robert Zelle
  • Compositions useful as inhibitors of protein kinases
    Publication number: 20050137201
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: September 7, 2004
    Publication date: June 23, 2005
    Inventors: Alex Aronov, David Lauffer, Pan Li, Ronald Tomlinson
  • Pyrrole compositions useful as inhibitors of c-Met
    Publication number: 20050101650
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: August 16, 2004
    Publication date: May 12, 2005
    Inventors: Alex Aronov, Upul Bandarage, David Lauffer, Pan Li, Ronald Tomlinson
  • Cyclized amino acid derivatives
    Patent number: 6849630
    Abstract: The present invention relates to cyclized amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: February 1, 2005
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Brian Ledford
  • N-heterocyclic derivatives
    Patent number: 6747042
    Abstract: The present invention relates N-heterocyclic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: June 8, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • N-substituted glycine derivatives
    Publication number: 20040072821
    Abstract: The present invention relates N-substituted glycine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: October 2, 2003
    Publication date: April 15, 2004
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • Azo amino acids derivatives
    Patent number: 6716860
    Abstract: The present invention relates to azo amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: April 6, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Michael Mullican
  • Piperazine and piperidine derivatives
    Publication number: 20040034019
    Abstract: The present invention relates to piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.
    Type: Application
    Filed: August 8, 2002
    Publication date: February 19, 2004
    Inventors: Ronald Tomlinson, David Lauffer, Michael Mullican
  • Bicyclic derivatives
    Publication number: 20040029912
    Abstract: The present invention relates to bicylic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: August 1, 2003
    Publication date: February 12, 2004
    Inventors: David Lauffer, Michael Mullican
  • N-substituted glycine derivatives
    Patent number: 6677359
    Abstract: The present invention relates N-substituted glycine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: January 13, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • Bicyclic derivatives
    Patent number: 6660748
    Abstract: The present invention relates to bicylic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: December 9, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Michael Mullican
  • Acyclic piperazine and piperidine derivatives
    Publication number: 20030191117
    Abstract: The present invention relates to acyclic piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.
    Type: Application
    Filed: June 13, 2002
    Publication date: October 9, 2003
    Inventors: David Lauffer, Ronald Tomlinson, Eckhard Ottow, Martyn Botfield
  • Cyclized amino acid derivatives
    Publication number: 20030186960
    Abstract: The present invention relates to cyclized amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: October 2, 2003
    Inventors: David Lauffer, Brian Ledford
  • Acyclic and cyclic amine derivatives
    Publication number: 20030144253
    Abstract: The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 30, 2002
    Publication date: July 31, 2003
    Inventors: Michael Mullican, David Lauffer, Roger Tung
  • Cyclized amide derivatives
    Publication number: 20030130256
    Abstract: The present invention relates to cyclized amide derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: February 5, 2003
    Publication date: July 10, 2003
    Inventors: David Lauffer, Michael Mullican, Brian Ledford
  • Azo amino acids derivatives
    Publication number: 20030109526
    Abstract: The present invention relates to azo amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: December 2, 2002
    Publication date: June 12, 2003
    Inventors: David Lauffer, Michael Mullican
  • Compositions useful as inhibitors of GSK-3
    Publication number: 20030096813
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: April 19, 2002
    Publication date: May 22, 2003
    Inventors: Jingrong Cao, Debbie Choquette, Robert Davies, Cornelia Forster, David Lauffer, Albert Pierce, Ronald Tomlinson, Marion Wannamaker, Natalie Metz
  • Cyclized amide derivatives
    Patent number: 6552041
    Abstract: The present invention relates to cyclized amide derivatives of formula (I) These cyclized amide derivatives are useful for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: April 22, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Michael Mullican, Brian Ledford
  • Azo amino acids derivatives
    Patent number: 6528533
    Abstract: The present invention relates to azo amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: March 4, 2003
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: David Lauffer, Michael Mullican
  • Cyclic amine derivatives
    Publication number: 20020123493
    Abstract: The present invention relates to cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: September 5, 2002
    Inventors: Michael Mullican, David Lauffer