Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: The present disclosure concerns a curvature-changing, accommodative intraocular lens (IOL) for implantation in the capsular bag of a patient's eye. The IOL includes a fluid optic body having a cavity for containing an optical fluid, the cavity at least partially defined by a sidewall extending around the cavity and defining a diameter of the cavity and a deformable optical membrane intersecting the sidewall around a circumference of the sidewall and spanning the diameter of the cavity. The IOL further includes a second optic body spaced a distance apart from the fluid optic body and a plurality of struts extending from the sidewall and coupling the fluid optic body to the second optic body. The struts are configured such that axial compression of the capsular bag causes the struts to deform the sidewall in a manner that increases the diameter of the cavity, modifying a curvature of the deformable optical membrane.

Abstract: The present disclosure provides a composition comprising a solid support, a plurality of tethered oligonucleotides attached to the solid support, and a plurality of untethered oligonucleotides hybridized to the tethered oligonucleotides. An untethered oligonucleotide can comprise, attached via the 5? end, a cell, or an effector molecule. Hybridization of an untethered oligonucleotide to a tethered oligonucleotide generates an enzyme cleavage site, which allows for temporally controlled removal of an effector molecule. The present disclosure provides methods of temporally modulating the activity and/or phenotype of a cell. The present disclosure provides a solid support comprising patterned tethered oligonucleotides attached thereto; and methods of making the solid support.

Abstract: A graphene Hall sensor for operation at cryogenic temperatures is provided. The graphene Hall sensor comprises a substrate, a graphene sheet, a dielectric layer, a first pair of electrical contacts, and a second pair of electrical contacts. The graphene sheet is provided on the substrate. The dielectric layer is provided on the graphene sheet. The graphene sheet and the dielectric layer share a continuous outer edge surface. The first pair of electrical contacts are in electrical contact with the graphene sheet and spaced apart along a first direction. The second pair of electrical contacts are in electrical contact with the graphene sheet and spaced apart along a second direction. The first direction is perpendicular to the second direction, wherein a path along the first direction between the first pair of electrical contacts crosses a path along the second direction between the second pair of electrical contacts. The graphene sheet has a sheet carrier density in the range of 2×1011 cm?2 to 1×1013 cm?2.

Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Abstract: The disclosure provides methods of treating obesity, reducing weight, or preventing weight gain using a combination therapy of GDF15 polypeptide and a myostatin inhibitor (e.g., a myostatin propeptide).

Abstract: A method for determining a charging price for an electric charging site includes receiving time tags and data obtained based on automated metering infrastructure (AMI) data for the electric charging site, and weather information for a service area of the electric charging site; clustering power consumption of the electric charging site with similar weather information and time tags; calculating a center of mass and a distribution confidence parameter for the clustered power consumption to obtain a look-up table; retrieving historical information of voltage VPCC and injection power Psite pairs that is measured at a point of common coupling (PCC) of the electric charging site; receiving weather forecast information for the service area of the electric charging site; and calculating a dynamic hosting capacity (DHC) curve and a price curve based on the center of mass and the distribution confidence parameter, the VPCC and Psite pairs, and the weather forecast information.

Abstract: An implantable system includes an implantable medical device (IMD) and a non-transvenous lead that is configured to be implanted outside of a heart. The IMD includes an output configured to be connected at least to the lead, a current generator (CG) circuit configured to generate pacing pulses, a switching circuit coupled between the CG circuit and the output, one or more capacitors coupled in parallel with the CG circuit and the switching circuit, and a control circuit coupled to the CG circuit. The control circuit is configured to manage the CG circuit to generate the pacing pulses with a constant current at the output.

Abstract: The present invention describes a method using temperature data to protect battery health during bidirectional charging in conjunction with monetization activities. The method includes receiving temperature data and determining anticipated energy needs of a building. The temperature data includes at least the temperature of one or more electric vehicle batteries or information required to determine the temperature of the one or more electric vehicle batteries while the anticipated energy needs are relative to ambient air temperature. The method includes determining an amount of discharge of the one or more electric vehicle batteries required to offset the anticipated needs of the building by a predetermined amount and determining based on the temperature data whether discharging the one or more electric vehicle batteries would be harmful to the health of the one or more electric vehicle batteries.

Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: An implant removal device includes a body, a first arm, a second arm, an actuation interface, and an extraction member. The first arm is supported at the body and configured to move relative to the body between a retracted position and a skin gripping position. The second arm is supported at the body and configured to move relative to the body between the retracted position and the skin gripping position. The actuation interface is supported at the body. The actuation interface is configured to receive a first actuation input thereat to cause at least one of the first arm and the second arm to move from the skin gripping position to the retracted position. The extraction member is supported at the body and located between the first arm and the second arm.

Abstract: A tool system for installing a parking pawl includes a tool that includes a base, a plate, and an actuator. The base includes a base surface configured to support a parking pawl in a predetermined position. The plate includes a protrusion that extends upward from a front portion of the plate. A rear portion of the plate is coupled to a front portion of the base. The plate is movable relative to the base between a retention position in which the protrusion is positioned to retain a pawl spring loaded on the parking pawl in a pretensioned state, and a release position in which the protrusion is configured to release the pawl spring. The actuator is operably coupled to the plate such that activation of the actuator moves the plate between the retention position and the release position.

Abstract: In one embodiment, a coupler includes a glass tube having a refractive index n3 and a passageway, a first optical waveguide and a second optical waveguide positioned within the passageway, each of the first optical waveguide and the second optical waveguide comprising a core surrounded by a cladding. The glass tube further includes a tapered region having a taper length. A coupling region is present between the first optical waveguide and the second optical waveguide within the tapered region. A refractive index of the cladding is less than a refractive index of the core, and a lowest refractive index of the cladding of the first optical waveguide and the second optical waveguide is n2. Additionally, n3 is lower than n2 such that a value of ?2-3 is 0.07%??2-3?0.125, where ?2-3 equals (n22?n32)/2n22.

Abstract: An extraction cleaner having a cleanout tool for use with a surface cleaning apparatus such as an extraction cleaner or vacuum cleaner includes a nozzle cleaning implement and a brush cleaning implement.

Abstract: Concepts presented herein relate to an interface module that can be electrically coupled to an electrical stimulation generator, a radio frequency generator and an instrument. A selection module is coupled to the interface module and operates in a first mode to deliver electrical stimulation signals from the electrical stimulation generator to the instrument and in a second mode to deliver radio frequency signals from the radio frequency generator to the instrument.

Abstract: This disclosure describes systems, methods, and devices related to programmatically updating the status of assets tracked in a supply chain environment. A system may be configured to obtain first sensor data collected from a first tracking device associated with a first asset, determine asset workflow information associated with the first asset, determine an intelligence engine configured to generate an inference of a status associated with the first asset, determine the status associated with the first asset, wherein the status is determined by the intelligence engine based on the first sensor data and the asset workflow information, and store the status of the first asset in an asset tracking database.

Abstract: An exposed secondary showerhead system configured to be supported by a conventional shower enclosure. The illustrative showerhead system includes an overhead conduit fluidly coupled to a conventional shower inlet pipe and to at least one showerhead.

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Abstract: Implementations generally relate to an assembly of an integrated circuit in a chip scale ball grid array. In some implementations, an assembly includes an integrated circuit (IC) chip having wire bond pads. The assembly further includes ball bumps coupled to the wire bond pads of the IC chip. The assembly further includes an overmold that encapsulates the IC chip. The assembly further includes ball contact pads coupled to the overmold, wherein the ball contact pads are electrically coupled to the wire bond pads by way of the ball bumps. The assembly further includes solder balls coupled to the ball contact pads.

Abstract: Systems are provided for logging transactions in heterogeneous networks that include a combination of one or more instrumented components and one or more non-instrumented components. The instrumented components are configured to generate impersonated log records for the non-instrumented components involved in the transaction processing hand-offs with the instrumented components. The impersonated log records are persisted with other log records that are generated by the instrumented components in a transaction log that is maintained by a central logging system to reflect a complete flow of the transaction processing performed on the object, including the flow through the non-instrumented component(s).