Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.

Abstract: An anti-fouling shield composite material for shielding and removing ice or slush from a surface and a method of forming the same. The composite material including a cured organogel matrix and an auxetic skeletal structure, wherein the composite material has a negative Poisson's ratio that results in an increase in net surface area of the shield to shed ice from a surface of the shield when stretched. The method including mixing a silicone and a silicone oil to form an uncured organogel matrix; separately mixing fumed silica and a silicone precursor to form a second uncured material; curing the second uncured material to form the cured auxetic skeletal structure and molding that into a shape of the anti-fouling shield; pouring the uncured organogel matrix around and covering the cured auxetic skeletal structure; and curing the uncured organogel matrix to form the anti-fouling shield composite material.

Abstract: A sintered article may be formed from a composition containing at least sinterable thermoplastic particles and a curable (meth)acrylate resin component, wherein the sinterable thermoplastic particles are insoluble in the curable (meth)acrylate resin component at 25° C. The curable (meth)acrylate resin component may be cured, thereby forming an intermediate article which may be converted into a sintered article using conditions effective to remove at least a portion of the matrix formed by the cured curable (meth)acrylate resin component and to sinter the thermoplastic particles.

Abstract: An example apparatus having a first and second data terminal and including a first transistor having a first terminal, a second terminal, and a control terminal; a second transistor having a first terminal and a control terminal, the first terminal of the second transistor coupled to the first terminal of the first transistor; a third transistor having a first terminal, a second terminal, and a control terminal; a fourth transistor having a first terminal and a control terminal, the first terminal of the fourth transistor coupled to the first terminal of the third transistor; and gate driver circuitry having a first terminal, and a second terminal, the first terminal of the gate driver circuitry coupled to the first data terminal, and the second terminal of the first transistor, the second terminal of the gate driver circuitry coupled to the second data terminal and the second terminal of third transistor.

Abstract: Systems and methods are provided for facilitating the management of AI (artificial intelligence) agents, AI agent skills, and customer access to AI agents and AI agent skills. Systems identify an AI agent and AI agent skills that the AI agent can utilize when interacting with different customers. The systems also identify a plurality of customers that the AI agent is capable of interacting with while utilizing one or more of the AI agent skills. The systems also generate and display interfaces that identify the plurality of customers with interactive permission controls for selectively enabling and/or disabling AI agent interactions by the AI agent the corresponding customers.

Abstract: An example apparatus having a first and second data terminal and including a first transistor having a first terminal, a second terminal, and a control terminal; a second transistor having a first terminal and a control terminal, the first terminal of the second transistor coupled to the first terminal of the first transistor; a third transistor having a first terminal, a second terminal, and a control terminal; a fourth transistor having a first terminal and a control terminal, the first terminal of the fourth transistor coupled to the first terminal of the third transistor; and gate driver circuitry having a first terminal, and a second terminal, the first terminal of the gate driver circuitry coupled to the first data terminal, and the second terminal of the first transistor, the second terminal of the gate driver circuitry coupled to the second data terminal and the second terminal of third transistor.

Abstract: Provided are novel anti-SEZ6 antibodies and antibody drug conjugates, and methods of using such anti-SEZ6 antibodies and antibody drug conjugates to treat cancer.

Abstract: The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.

Abstract: The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.

Abstract: The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.

Abstract: The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.

Abstract: Various embodiments are described herein for a device and method for interacting with customers on e-commerce platforms. The various embodiments described herein generally relate to methods and apparatus for interacting with customers. In one embodiment, the system may be used in conjunction with e-commerce platforms, electronic document platforms, and any other electronic platforms. In other embodiments, the interaction with customers can be on electronic documents, portable document formats (PDFs), email and other forms of electronic platforms. On e-commerce platforms, customers can use electronic devices such as laptops, tablets, and mobile devices to browse products before deciding to make a purchase decision.

Abstract: The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of a4?7 to the mucosal addressing cell adhesion molecule (MAdCAM) in vivo.

Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.

Abstract: An electronic device, method, and computer readable medium for an invertible wavelet layer for neural networks are provided. The electronic device includes a memory and at least one processor coupled to the memory. The at least one processor is configured to receive an input to a neural network, apply a wavelet transform to the input at a wavelet layer of the neural network, and generate a plurality of subbands of the input as a result of the wavelet transform.

Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.

Abstract: Provided herein are mutant interleukin-10 polypeptides, and fusion polypeptides comprising the mutant interleukin-10 polypeptides and antigen binding molecules. The present disclosure provides methods of modulating immune cell function by contacting the immune cell with fusion polypeptides of the present disclosure. In addition, the disclosure also provides polynucleotides encoding the disclosed fusion molecules, and vectors and host cells comprising such polynucleotides. The present disclosure further provides methods for producing the fusion molecules, pharmaceutical compositions comprising the same, and uses thereof.

Abstract: A demand-based load balancing function may be provided by one or more drive controllers that takes advantage of the affinity laws to linearize the control of the variable of interest (e.g., flow, pressure, etc.). Each drive controller may be set up by the user simply inputting a few values into the drive controller. Based on the inputs, the drive controllers may interpolate control points using an assumed linear relationship between the variable to be controlled (e.g., pressure) and the current driven to the pump. Feedback data from the system may be used to continually update the drive controllers so as to potentially allow them to better balance power usage to each pump.