Abstract: A method for analyzing one or more conditions of a transportation pathway includes obtaining, using an imaging device of an inspection system, image data reproducible as a plurality of images of the transportation pathway, each of the plurality of images being reproducible as an image of a portion of the transportation pathway, each portion of the transportation pathway having an associated location along a length of the transportation pathway, analyzing, using one or more processors of the inspection system, the image data to determine a first plurality of metrics indicative of a condition of the transportation pathway at each of the associated locations, and generating a first graph, using the determined first plurality of metrics, that is indicative of the condition of the transportation pathway at each of the associated locations.

Abstract: The present disclosure provides methods and systems for tracking a shipping vessel travel route through a retail enterprise during a stock cycle. Location information associated with assets can be collected at a retail location, from which a detailed route through the retail location may be recreated and overlaid on map data reflecting a retail location layout. Further analysis may be performed on the route. Additionally, the route may be overlaid on a map, including product information and packaging information, allowing for various metrics and metric visualizations to be generated that can be further analyzed to achieve various objectives.

Abstract: The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting or blocking NUAK kinase, such as cancers and fibrosis.

Abstract: A bag including a childproof resealable closure system. The bag includes an opening extending from a first end to a second end configured with a closure system to seal the opening. The closure system includes a first elongate closure element and a second elongate closure element, coupled to opposing sidewalls of the bag and extending from the first end to the second end. The first and second elongate closure elements may be resealably interlocked to provide the seal. The first closure element may be coupled to its sidewall along its lower portion while leaving the upper portion of the closure element substantially disconnected. The second closure element may be coupled to its sidewall along its upper and lower portions. The second closure element may include a discreet partial gap along its length to facilitate the gripping and separating of the closure system, to render the resealable bag childproof.

Abstract: This invention provides, among other things, compounds useful for treating diseases such as fibrosis and/or cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

Abstract: A polyfunctional organohydrogensiloxane is prepared using a boron containing Lewis acid as catalyst. The polyfunctional organohydrogensiloxane may be formulated into release coating compositions. Alternatively, the polyfunctional organohydrogensiloxane may be further functionalized with a curable group to form a clustered functional organosiloxane. The clustered functional organosiloxane may be formulated into thermal radical cure adhesive compositions.

Abstract: Systems and methods are provided for dynamically modeling and depicting overall emissions of the aviation industry and changes thereto when taking into account, for example, traffic growth and introduction of sustainability strategies, such as new and/or improved technologies, an increase in operational efficiency, and carbon offsets. Using the dynamic tool described herein, users can define scenarios on how to reduce emissions through the introduction of different sustainability strategies, both statically and over time, analyze the impact of those strategies on emissions, and understand the dependencies between select strategies.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: A surface cleaning apparatus including a body defining an agitation chamber, an agitator partially disposed within the agitation chamber and configured to rotate about a pivot axis, and a debrider at least partially disposed within the agitation chamber. The agitator includes an elongated body having a first and a second end, a sidewall extending radially outward from the elongated body extending between the first and the second ends, and a plurality of bristles extending radially outward from the elongated body. The plurality of bristles are arranged in at least one row adjacent to the sidewall. The debrider includes a plurality of teeth configured to contact a portion of the sidewall as the agitator rotates about the pivot axis.

Abstract: Disclosed are various embodiments facilitating a holistic engagement with a user across multiple communication channels of an organization or an enterprise based at least in part on a determined user intent. As users interact with various services associated with the organization through one or more communication channels, interaction data can be captured and stored. In various examples, the interaction data that is stored by the various services can be obtained and organized according to a predefined schema. The organized interaction data can be applied to a trained intent model that outputs a user intent based at least in part on observations of other users with similar histories. The predicted intent can be provided to the different services such that subsequent interactions between the user and the organization can be based at least in part on the intent in a consistent manner, regardless of the communication channel associated with the interaction.

Abstract: Red rust staining of Al/Zn coated steel strip in “acid rain” or “polluted” environments can be minimised by forming the coating as an Al—Zn—Si—Mg alloy coating with an OT:SDAS ratio greater than a value of 0.5:1, where OT is the overlay thickness on a surface of the strip and SDAS is the measure of the secondary dendrite arm spacing for the Al-rich alpha phase dendrites in the coating. Red rust staining in “acid rain” or “polluted” environments and corrosion at cut edges in marine environments can be minimised in Al—Zn—Si—Mg alloy coatings on steel strip by selection of the composition (principally Mg and Si) and solidification control (principally by cooling rate) and forming Mg2Si phase particles of a particular morphology in interdendritic channels.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: A technique for providing search results may include determining a first entity type, a second entity type, and a relationship type based on a compositional query. The technique may also include identifying nodes of a knowledge graph corresponding to entity references of the first entity type and entity references of the second entity type. The technique may also include determining from the knowledge graph an attribute value corresponding to the relationship type for each entity reference of the first entity type and for each entity reference of the second entity type. The technique may also include comparing the attribute value of each entity reference of the first entity type with the attribute value of each entity reference of the second entity type. The technique may also include determining one or more resultant entity references from the entity references of the first entity type based on the comparing.

Abstract: A method of assisting a user with the discovery of program features is provided. The method includes detecting a selection of a data structure within a user interface, determining a contextual parameter based on the selected data structure, the contextual parameter associated with a modifiable feature of the selected data structure, determining options for generating program code configured to modify the modifiable feature are available based on the contextual parameter and a predefined inferential relationship between the contextual parameter and the modifiable feature of the selected data structure, and prompting the user in the user interface with information indicating that the determined options for generating the program code are accessible in the user interface.

Abstract: The disclosed devices may include a driver circuit including a voltage boost circuit, a pulse modulation controller, and optionally a headroom processor. The voltage boost circuit may be configured to receive a device input voltage (such as a battery voltage) and generate a backlight drive voltage. The pulse modulation controller may be configured to provide a pulse modulation signal to the voltage boost circuit, and may include a digital circuit or an analog circuit. Example devices may include a backlight unit receiving the backlight voltage. The optional headroom processor may provide a headroom signal to the pulse modulation controller based on a headroom voltage determined from the backlight unit. Devices may further include a backlight unit including an arrangement of light-emissive elements, and may include display devices such as head-mounted devices. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with ?-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.

Abstract: Methods and apparatus to generate and display trends associated with a process control system are disclosed. An example apparatus includes memory, machine readable instructions, and processor circuitry to execute the instructions to generate a first graphical user interface. The first graphical user interface to include a graphical representation of a component in a process control system. The processor circuitry to generate a second graphical user interface. The second graphical user interface to include a chart region with a trend represented therein. The trend indicative of values of a process parameter of the process control system over a period of time. The processor circuitry to automatically generate the trend in the chart region in response to a graphical element being dragged and dropped from the first graphical user interface to the second graphical user interface.

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

Abstract: An audio device with a body configured to be worn on or abutting an outer ear of a user, wherein the body is configured to contact at least one of the outer ear and the portion of the head that abuts the outer ear, at two separate spaced contact locations, and wherein the body is compliant at a body portion that defines one of the contact locations. The device also has an acoustic module carried by the body and configured to locate a sound-emitting opening anteriorly of and proximate the user's ear canal opening when the body is worn on or abutting the ear of the user.

Abstract: In some embodiments, an electrode can include a current collector, a composite material in electrical communication with the current collector, and at least one phase configured to adhere the composite material to the current collector. The current collector can include one or more layers of metal, and the composite material can include electrochemically active material. The at least one phase can include a compound of the metal and the electrochemically active material. In some embodiments, a composite material can include electrochemically active material. The composite material can also include at least one phase configured to bind electrochemically active particles of the electrochemically active material together. The at least one phase can include a compound of metal and the electrochemically active material.